RTN4IP1 and CBFA2T3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		RTN4IP1	CBFA2T3
Name		reticulon 4 interacting protein 1	CBFA2/RUNX1 partner transcriptional co-repressor 3
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix Membrane	Golgi Membrane Nucleus Nucleoplasm Nucleolus Golgi Apparatus Membrane
	Molecular Function	Nucleotide Binding Protein Binding Zinc Ion Binding NADPH Dehydrogenase (quinone) Activity Oxidoreductase Activity	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Ubiquinone Biosynthetic Process Nervous System Development Regulation Of Dendrite Development	Response To Hypoxia DNA-templated Transcription Negative Regulation Of Cell Population Proliferation Cell Differentiation Granulocyte Differentiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Regulation Of Aerobic Respiration
GWAS		Daytime sleep phenotypes ( 27126917 ) Metabolite levels ( 23823483 )	Annualised percent change of cerebrospinal fluid AB1-42 levels ( 31370031 ) Carotid intima media thickness ( 30510157 ) Carotid intima media thickness (mean) ( 31801372 ) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189 ) Hair color ( 26926045 ) Hemoglobin levels ( 32327693 ) Immature fraction of reticulocytes ( 32888494 ) Levodopa-induced dyskinesia in levodopa treated Parkinson's disease ( 32733355 ) Lymphocyte percentage of white cells ( 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 32888494 ) Mean platelet volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Multiple sclerosis ( 31604244 ) Neutrophil count ( 32888494 ) Red cell distribution width ( 32888494 ) Red vs. brown/black hair color ( 30531825 ) Social autistic-like traits ( 24133439 ) Vitiligo ( 27723757 )
Novel Interactors		None recorded	1 novel interactors: NUP98
Interacting Genes		23 interacting genes: ARFGAP3 CALCOCO2 CBFA2T3 CENPK CTAG1A CTAG1B ERMN EXOC7 GGA2 HDX MARCHF5 PPP1R8 PYM1 RELA RTN4 RTN4R RUNX1T1 SCAF1 SMURF2 SORBS1 WBP11 WWTR1 ZYX	23 interacting genes: ARHGEF6 CBFA2T2 CHRM4 DRC4 EPM2AIP1 GATAD2A GMEB2 HDAC1 HDAC3 MATN2 PIN1 PRKAR2A RTN4IP1 RUNX1 RUNX1T1 SEC24A TCF3 VPS37C ZBTB33 ZBTB38 ZBTB4 ZBTB47 ZNF652
Entrez ID		84816	863
HPRD ID		18008	04847
Ensembl ID		ENSG00000130347	ENSG00000129993
Uniprot IDs		Q8WWV3	O75081
PDB IDs		2VN8	9DE2
GO Terms Enriched among Interactors		RNA Metabolic Process	Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Protein Lysine Delactylase Activity Methyl-CpG Binding Negative Regulation Of RNA Metabolic Process Protein Decrotonylase Activity Histone Decrotonylase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Binding DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Zinc Ion Binding Protein Deacetylation Protein Lysine Deacetylase Activity Transcription Corepressor Activity Nucleoplasm NuRD Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Myotube Differentiation Negative Regulation Of Macromolecule Metabolic Process Histone Deacetylase Activity Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Fate Specification Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Macromolecule Deacylation NF-kappaB Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Telomere Tethering At Nuclear Periphery Cis-trans Isomerase Activity Positive Regulation Of Ferroptosis Methyl-CpNpG Binding Regulation Of Metabolic Process Negative Regulation Of Striated Muscle Cell Differentiation Histone Deacetylase Complex Regulation Of Myotube Differentiation Regulation Of Cell Fate Commitment