PSRC1 and SRGN

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PSRC1	SRGN
Gene Name		proline/serine-rich coiled-coil 1	serglycin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleoplasm Cytoplasm Spindle Cytosol Spindle Microtubule Microtubule Cytoskeleton Midbody	Golgi Membrane Extracellular Region Extracellular Space Golgi Apparatus Platelet Alpha Granule Lumen Zymogen Granule Mast Cell Granule
	Molecular Function	Protein Binding Microtubule Binding	Protein Binding Collagen Binding
	Biological Process	Microtubule Bundle Formation Mitotic Metaphase Plate Congression Negative Regulation Of Cell Growth Positive Regulation Of Microtubule Polymerization Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription, DNA-templated Cell Division Regulation Of Mitotic Spindle Organization	Platelet Degranulation Blood Coagulation Granzyme-mediated Apoptotic Signaling Pathway Protein Processing Platelet Activation Negative Regulation Of Bone Mineralization Biomineral Tissue Development Mast Cell Secretory Granule Organization T Cell Secretory Granule Organization Maintenance Of Protease Location In Mast Cell Secretory Granule Maintenance Of Granzyme B Location In T Cell Secretory Granule Negative Regulation Of Cytokine Secretion
Pathways			Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) Coronary heart disease ( 17634449 21378988) LDL cholesterol ( 18262040 18179892 18193043 18193044 19060906 19060910 20686565) Lipid metabolism phenotypes ( 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 20442857) Metabolite levels ( 21909109) Myocardial infarction (early onset) ( 19198609) Progranulin levels ( 21087763) Response to statin therapy ( 20339536)
Protein-Protein Interactions		2 interactors: APP SRGN	12 interactors: ALB BAG6 CCL3 CD44 CEP70 GZMB PF4 PSRC1 SGTA UBQLN1 UBQLN4 UBR4
Entrez ID		84722	5552
HPRD ID		13127	01513
Ensembl ID		ENSG00000134222	ENSG00000122862
Uniprot IDs		A8K0M8 Q6PGN9	P10124
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Platelet Activation Maintenance Of Granzyme B Location In T Cell Secretory Granule T Cell Secretory Granule Organization Maintenance Of Protease Location In Mast Cell Secretory Granule Synaptic Growth At Neuromuscular Junction Mast Cell Secretory Granule Organization Exocytosis Collateral Sprouting In Absence Of Injury Blood Coagulation Hemostasis Collateral Sprouting Axon Midline Choice Point Recognition Granzyme-mediated Apoptotic Signaling Pathway Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Secretion By Cell Axon Choice Point Recognition Regulation Of Body Fluid Levels Wound Healing Secretion Neuron Remodeling Cell Activation Response To Wounding Cellular Copper Ion Homeostasis Apoptotic Process Negative Regulation Of Bone Mineralization Negative Regulation Of Biomineral Tissue Development Copper Ion Homeostasis Suckling Behavior Programmed Cell Death Cell Death Death Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cytokine Secretion RNA Polyadenylation Neuron Recognition Secretory Granule Organization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Vesicle-mediated Transport Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development	Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Behavior Cytolysis Regulation Of Behavior Leukocyte Migration Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Leukocyte Chemotaxis Exocytosis Platelet Degranulation Negative Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Programmed Cell Death Positive Regulation Of Leukocyte Migration Positive Regulation Of Monocyte Aggregation Maintenance Of Mitochondrion Location Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Cell Death Blood Coagulation Inflammatory Response Hemostasis Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Myeloid Leukocyte Differentiation Regulation Of Leukocyte Migration Monocyte Aggregation Response To Platinum Ion Negative Regulation Of Cytolysis Hemolysis By Symbiont Of Host Erythrocytes Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Eosinophil Degranulation Regulation Of Cellular Protein Metabolic Process Secretion By Cell Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chemotaxis Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Natural Killer Cell Chemotaxis Granzyme-mediated Apoptotic Signaling Pathway Cellular Response To Interferon-gamma Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus Positive Regulation Of Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Immune System Process Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Negative Regulation Of MHC Class II Biosynthetic Process Wound Healing Immune Response
Tagcloud ?		ags aurka aurkb bop1 bub1 bub1b ccna2 ccnb1 ccne2 cdc20 cdc25b cdc25c cdk5 cdkn1a cenpe deoxyribonucleotides earliest foxm1 illumina impdh inosine kegg mcm2 monophosphate mpa mycophenolic rrm1 segregation transcriptomic	bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 ncr3 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 sema6a trem2 tubal3 txnrd1
Tagcloud (Difference) ?		ags aurka aurkb bop1 bub1 bub1b ccna2 ccnb1 ccne2 cdc20 cdc25b cdc25c cdk5 cdkn1a cenpe deoxyribonucleotides earliest foxm1 illumina impdh inosine kegg mcm2 monophosphate mpa mycophenolic rrm1 segregation transcriptomic	bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 ncr3 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 sema6a trem2 tubal3 txnrd1
Tagcloud (Intersection) ?