PSRC1

Description		proline and serine rich coiled-coil 1
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleoplasm Cytoplasm Spindle Cytosol Cytoskeleton Spindle Microtubule Microtubule Cytoskeleton Midbody
	Molecular Function	Protein Binding Microtubule Binding
	Biological Process	Microtubule Bundle Formation Mitotic Metaphase Chromosome Alignment Negative Regulation Of Cell Growth Positive Regulation Of Microtubule Polymerization Positive Regulation Of DNA-templated Transcription Cell Division Regulation Of Mitotic Spindle Organization
Pathways
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 27899403) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alanine aminotransferase levels ( 33547301) Cholesterol ( 31902109) Cholesterol, total ( 20686565) Coronary artery disease ( 29212778 32469254) Coronary heart disease ( 21378988 17634449) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) LDL cholesterol ( 19060910 20686565 19060906 21347282 18262040 18193044 18193043 18179892) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222) Lipoprotein (a) levels ( 33730874) Lipoprotein-associated phospholipase A2 activity and mass ( 20442857) Low density lipoprotein cholesterol levels ( 30718733) Medication use (salicylic acid and derivatives) ( 31015401) Metabolite levels ( 21909109) Myocardial infarction (early onset) ( 19198609) Parental lifespan ( 30642433) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Progranulin levels ( 29186428 21087763) Response to statin therapy ( 20339536) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271)
Interacting Genes		8 interacting genes: AKT1 APP ASB7 AURKA CDK1 MAPRE3 PLK1 SRGN
Entrez ID		84722
HPRD ID		13127
Ensembl ID		ENSG00000134222
Uniprot IDs		A8K0M8 Q6PGN9
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Positive Regulation Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Positive Regulation Of Protein Catabolic Process Regulation Of Protein Localization To Nucleus Regulation Of Mitotic Cell Cycle Spindle Microtubule Centrosome Cycle Midbody G2/M Transition Of Mitotic Cell Cycle Protein Localization To Cytoskeleton Spindle Midzone Cell Cycle G2/M Phase Transition Spindle Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Microtubule Cytoskeleton Protein Localization To Organelle Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Microtubule Organizing Center Organization Protein Phosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Positive Regulation Of Protein Localization To Nucleus Microtubule-based Process Mitotic Nuclear Membrane Disassembly Cilium Disassembly Protein Serine Kinase Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Centrosome Separation Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Phosphorylation Apoptotic Process Regulation Of Cell Cycle G2/M Phase Transition Protein Serine/threonine Kinase Activity Nuclear Membrane Disassembly Programmed Cell Death Cell Death Microtubule Cytoskeleton Organization Involved In Mitosis Membrane Disassembly Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Regulation Of Postsynapse Organization Microtubule Cytoskeleton Organization
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