PSRC1 and ASB7

Number of citations of the paper that reports this interaction (PubMedID 27697924)
42

Data Source:
BioGRID (enzymatic study)

		PSRC1	ASB7
Description		proline and serine rich coiled-coil 1	ankyrin repeat and SOCS box containing 7
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleoplasm Cytoplasm Spindle Cytosol Cytoskeleton Spindle Microtubule Microtubule Cytoskeleton Midbody	Cytosol
	Molecular Function	Protein Binding Microtubule Binding	Protein Binding
	Biological Process	Microtubule Bundle Formation Mitotic Metaphase Chromosome Alignment Negative Regulation Of Cell Growth Positive Regulation Of Microtubule Polymerization Positive Regulation Of DNA-templated Transcription Cell Division Regulation Of Mitotic Spindle Organization	Protein Ubiquitination Intracellular Signal Transduction
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 27899403) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alanine aminotransferase levels ( 33547301) Cholesterol ( 31902109) Cholesterol, total ( 20686565) Coronary artery disease ( 29212778 32469254) Coronary heart disease ( 21378988 17634449) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) LDL cholesterol ( 19060910 20686565 19060906 21347282 18262040 18193044 18193043 18179892) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222) Lipoprotein (a) levels ( 33730874) Lipoprotein-associated phospholipase A2 activity and mass ( 20442857) Low density lipoprotein cholesterol levels ( 30718733) Medication use (salicylic acid and derivatives) ( 31015401) Metabolite levels ( 21909109) Myocardial infarction (early onset) ( 19198609) Parental lifespan ( 30642433) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Progranulin levels ( 29186428 21087763) Response to statin therapy ( 20339536) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271)	Anti-drug antibodies in autoimmune disease (time to event) ( 33125391) Chin dimples ( 27182965) Chronotype ( 30696823) Lower body strength ( 27325353) Morning person ( 30696823) Optic cup area ( 25631615 28073927 31798171) Optic disc area ( 28073927) Response to taxane treatment (paclitaxel) ( 23006423) Vertical cup-disc ratio ( 28073927 31798171) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		8 interacting genes: AKT1 APP ASB7 AURKA CDK1 MAPRE3 PLK1 SRGN	3 interacting genes: ATF4 CDK2 PSRC1
Entrez ID		84722	140460
HPRD ID		13127	10674
Ensembl ID		ENSG00000134222	ENSG00000183475
Uniprot IDs		A8K0M8 Q6PGN9	Q9H672
PDB IDs			8Y1U
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Positive Regulation Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Positive Regulation Of Protein Catabolic Process Regulation Of Protein Localization To Nucleus Regulation Of Mitotic Cell Cycle Spindle Microtubule Centrosome Cycle Midbody G2/M Transition Of Mitotic Cell Cycle Protein Localization To Cytoskeleton Spindle Midzone Cell Cycle G2/M Phase Transition Spindle Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Microtubule Cytoskeleton Protein Localization To Organelle Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Microtubule Organizing Center Organization Protein Phosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Positive Regulation Of Protein Localization To Nucleus Microtubule-based Process Mitotic Nuclear Membrane Disassembly Cilium Disassembly Protein Serine Kinase Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Centrosome Separation Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Phosphorylation Apoptotic Process Regulation Of Cell Cycle G2/M Phase Transition Protein Serine/threonine Kinase Activity Nuclear Membrane Disassembly Programmed Cell Death Cell Death Microtubule Cytoskeleton Organization Involved In Mitosis Membrane Disassembly Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Regulation Of Postsynapse Organization Microtubule Cytoskeleton Organization	Cytoskeleton Positive Regulation Of Cellular Component Biogenesis Cell Division Positive Regulation Of Organelle Organization Regulation Of Mitotic Spindle Organization Organelle Organization Lewy Body Core Response To Manganese-induced Endoplasmic Reticulum Stress ATF1-ATF4 Transcription Factor Complex L-asparagine Metabolic Process Regulation Of Cold-induced Thermogenesis Centrosome CHOP-ATF4 Complex Positive Regulation Of Sodium-dependent Phosphate Transport Positive Regulation Of Chromatin Organization Regulation Of Cell Cycle Process Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Microtubule-based Process Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization ATF4-CREB1 Transcription Factor Complex Asparagine Metabolic Process X Chromosome Regulation Of Cell Cycle Transcription Regulator Complex GDF15-GFRAL Signaling Pathway Negative Regulation Of Translational Initiation In Response To Stress Regulation Of Sodium-dependent Phosphate Transport Positive Regulation Of Cellular Component Organization Regulation Of Organelle Organization Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Histone Kinase Activity Regulation Of Microtubule-based Process Positive Regulation Of Metabolic Process Lens Fiber Cell Morphogenesis Protection From Non-homologous End Joining At Telomere Membraneless Organelle Assembly HRI-mediated Signaling Positive Regulation Of Spindle Assembly Regulation Of Phosphate Transport Cellular Response To Manganese Ion Regulation Of Heterochromatin Formation Mitochondrial Respirasome Assembly
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