TPST2 and CCR8

Number of citations of the paper that reports this interaction (PMID 17558413)
13

Data Source:
HPRD (in vitro)

		TPST2	CCR8
Gene Name		tyrosylprotein sulfotransferase 2	chemokine (C-C motif) receptor 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein-tyrosine Sulfotransferase Activity	Chemokine Receptor Activity Coreceptor Activity C-C Chemokine Receptor Activity
	Biological Process	Peptidyl-tyrosine Sulfation Fusion Of Sperm To Egg Plasma Membrane Prevention Of Polyspermy	Chemotaxis Immune Response Cell Adhesion G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemokine-mediated Signaling Pathway
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CCR1 CCR8 CMKLR1 GPR1 SELPLG	6 interactors: CCL1 CCL16 CCL17 CCL4 TPST1 TPST2
Entrez ID		8459	1237
HPRD ID		07217	03497
Ensembl ID		ENSG00000128294	ENSG00000179934
Uniprot IDs		O60704	P51685
PDB IDs		3AP1 3AP2 3AP3
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine G-protein Coupled Receptor Signaling Pathway Locomotion Cytokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Chemotaxis Cellular Response To Organic Substance Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Immune System Process Regulation Of Chemotaxis G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Leukocyte Adhesive Activation Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Response To Organic Substance Regulation Of Behavior Leukocyte Migration Cell Adhesion Cell Surface Receptor Signaling Pathway Immune Response Cellular Calcium Ion Homeostasis Positive Regulation Of Macrophage Chemotaxis Calcium Ion Homeostasis Cellular Response To Stimulus Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Monocyte Chemotaxis Leukocyte Tethering Or Rolling Cellular Metal Ion Homeostasis Regulation Of Macrophage Chemotaxis Regulation Of Monocyte Chemotaxis Dendritic Cell Chemotaxis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Response To External Stimulus Negative Regulation Of Interleukin-12 Production Negative Regulation Of Bone Mineralization Negative Regulation Of Biomineral Tissue Development Cellular Chemical Homeostasis Response To Stimulus Dendritic Cell Migration Ion Homeostasis	Cell Chemotaxis Peptidyl-tyrosine Sulfation Protein Sulfation Inflammatory Response Sulfation Chemotaxis Cell Migration Cell Motility Locomotion Immune Response Defense Response Movement Of Cell Or Subcellular Component Response To External Stimulus Prevention Of Polyspermy Immune System Process Cell-cell Signaling Positive Regulation Of Natural Killer Cell Chemotaxis Negative Regulation By Host Of Viral Transcription Sulfur Compound Metabolic Process Fusion Of Sperm To Egg Plasma Membrane Plasma Membrane Fusion Egg Activation Response To Stress Negative Regulation Of Viral Transcription Negative Regulation Of Myoblast Differentiation Positive Regulation Of Calcium-mediated Signaling Positive Chemotaxis Regulation Of Lymphocyte Migration Interaction With Symbiont Regulation Of Myoblast Differentiation Regulation Of Calcium-mediated Signaling Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Leukocyte Chemotaxis
Tagcloud ?		ameliorates backcross catalyzes ch chr chrs congenic d2mit255 d2mit304 d2mit62 dw dwarfism genetical grt hypoplasia hyporesponsiveness hypothyroidism indispensable linkage organogenesis progenies qtl qtls sulfation sulfotransferase svjcl ter thyroid tyrosylprotein	3p21 bimodal call chemokine chemokines chemotaxis chemr1 ckr cloning cxcr1 cxcr4 faint freshly l1 leukocytes lymphocytes mobilization nomenclature phytohemagglutinin responsiveness served stably stromal subnanomolar ter1 termed transfected unusual
Tagcloud (Difference) ?		ameliorates backcross catalyzes ch chr chrs congenic d2mit255 d2mit304 d2mit62 dw dwarfism genetical grt hypoplasia hyporesponsiveness hypothyroidism indispensable linkage organogenesis progenies qtl qtls sulfation sulfotransferase svjcl ter thyroid tyrosylprotein	3p21 bimodal call chemokine chemokines chemotaxis chemr1 ckr cloning cxcr1 cxcr4 faint freshly l1 leukocytes lymphocytes mobilization nomenclature phytohemagglutinin responsiveness served stably stromal subnanomolar ter1 termed transfected unusual
Tagcloud (Intersection) ?