MCHR2 and PMCH

Number of citations: 53 (PubMedID 11404457)
Data Source: HPRD (in vitro)

		MCHR2	PMCH
Name		melanin concentrating hormone receptor 2	pro-melanin concentrating hormone
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Nucleus Synapse
	Molecular Function	G Protein-coupled Receptor Activity Galanin Receptor Activity	Hormone Activity Melanin-concentrating Hormone Activity Type 1 Melanin-concentrating Hormone Receptor Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway	Neuropeptide Signaling Pathway Chemical Synaptic Transmission Spermatogenesis Feeding Behavior Cell Differentiation Negative Regulation Of Synaptic Transmission, Dopaminergic
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
GWAS		Adult body size ( 32376654 ) Apolipoprotein B levels ( 32203549 ) Circulating fibroblast growth factor 23 levels ( 30217807 ) Daytime nap ( 33568662 ) Erectile dysfunction ( 30297428 30583798 ) LDL cholesterol levels ( 32203549 ) Major depressive disorder ( 27479909 ) Menarche (age at onset) ( 21102462 25231870 ) Refractive error ( 32231278 ) Triglyceride levels ( 32203549 )	Adventurousness ( 30643258 ) Brain morphology (MOSTest) ( 32665545 ) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189 ) Height ( 19893584 ) Number of sexual partners ( 30643258 )
Interacting Genes		1 interacting genes: PMCH	10 interacting genes: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7
Entrez ID		84539	5367
HPRD ID		12088	01459
Ensembl ID		ENSG00000152034	ENSG00000183395
Uniprot IDs		Q969V1	P20382
PDB IDs		8WST	8WSS 8WST 8WWK 8WWL 8WWM 8WWN
GO Terms Enriched among Interactors		Type 1 Melanin-concentrating Hormone Receptor Binding Melanin-concentrating Hormone Activity Negative Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Synaptic Transmission Feeding Behavior Neuropeptide Signaling Pathway Hormone Activity	Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Protein Processing Hormone Metabolic Process Serine-type Peptidase Activity Protein Maturation Serine-type Endopeptidase Activity Peptidase Activity Endopeptidase Activity Regulation Of Hormone Levels Insulin Processing Peptide Metabolic Process Insulin Metabolic Process Neuropeptide Signaling Pathway Peptide Biosynthetic Process Regulation Of Nerve Growth Factor Production Nerve Growth Factor Production Regulation Of Biological Quality Proteolysis Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Viral Life Cycle Extracellular Space Cytokine Precursor Processing Nerve Growth Factor Binding Hydrolase Activity Endomembrane System Signal Peptide Processing Transport Vesicle Secretory Granule Golgi Lumen Secretion By Cell Peptide Binding Secretion Negative Regulation Of Inflammatory Response To Antigenic Stimulus Trans-Golgi Network Protein Metabolic Process Signaling Cell Communication Extracellular Region Golgi Apparatus Melanin-concentrating Hormone Receptor Activity Short-day Photoperiodism Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Islet Amyloid Polypeptide Processing G Protein-coupled Receptor Signaling Pathway Neuron Projection Cytoplasmic Vesicle