HOXC13 and ELF1

Number of citations of the paper that reports this interaction (PMID 18692240)
1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		HOXC13	ELF1
Gene Name		homeobox C13	E74-like factor 1 (ets domain transcription factor)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Protein Binding Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Hair Follicle Development Transcription, DNA-templated Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Nail Development Tongue Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter	Regulation Of Cytokine Production Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) ( 23648065) Biliary atresia ( 20460270) Waist-hip ratio ( 20935629)	Crohn's disease ( 23266558) Systemic lupus erythematosus ( 23273568 21044949)
Protein-Protein Interactions		7 interactors: APEX1 ELF1 HNRNPAB HOXC9 MEIS1 NR2E3 RHOXF2	8 interactors: HMGA1 HOXC13 NFKB1 NFYA NFYB RB1 REL SP1
Entrez ID		3229	1997
HPRD ID		00862	01808
Ensembl ID		ENSG00000123364	ENSG00000120690
Uniprot IDs		P31276	P32519 Q6MZZ4
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Positive Regulation Of Rhodopsin Gene Expression Developmental Process Eye Morphogenesis Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Rhodopsin Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Camera-type Eye Development Megakaryocyte Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Immune System Process Nucleotide-excision Repair, DNA Gap Filling Biosynthetic Process DNA Demethylation Negative Regulation Of Biosynthetic Process Cellular Response To Organic Cyclic Compound Eye Development Negative Regulation Of T Cell Receptor Signaling Pathway Cellular Nitrogen Compound Metabolic Process Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Organ Development Positive Regulation Of Cell Cycle G1/S Phase Transition Nuclear DNA Replication	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Enucleate Erythrocyte Differentiation Nitrogen Compound Metabolic Process Regulation Of Interleukin-12 Biosynthetic Process NIK/NF-kappaB Signaling Regulation Of Metabolic Process I-kappaB Kinase/NF-kappaB Signaling Regulation Of Interleukin-12 Production Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Sequestering Of Nodal From Receptor Via Nodal Binding Negative Regulation Of Interleukin-12 Biosynthetic Process Negative Regulation Of Gene Expression Erythrocyte Differentiation Regulation Of Cytokine Biosynthetic Process Negative Regulation Of Biosynthetic Process Viral Process Erythrocyte Homeostasis Negative Regulation Of Nodal Signaling Pathway Oncogene-induced Cell Senescence Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Myeloid Cell Homeostasis Negative Regulation Of Calcidiol 1-monooxygenase Activity
Tagcloud ?		chip deep dysregulated dysregulation h3k27me3 homeobox hoxb7 hoxd8 irx1 irx4 keratinocytes mark neoplastic okf6 oncomine polycomb prc prc2 repressive rnaseq scc six2 suz12 tert1r transcripts tshz3 tumorigenic	133a bidirectional biphasic compatible concurrently datasets declining directionally e2f ets ets2 gabp hf insult interrelated kegg late microrna mirna miss myocyte nonfailing omnibus overlapping overrepresented repository rising transcripts undergo
Tagcloud (Difference) ?		chip deep dysregulated dysregulation h3k27me3 homeobox hoxb7 hoxd8 irx1 irx4 keratinocytes mark neoplastic okf6 oncomine polycomb prc prc2 repressive rnaseq scc six2 suz12 tert1r tshz3 tumorigenic	133a bidirectional biphasic compatible concurrently datasets declining directionally e2f ets ets2 gabp hf insult interrelated kegg late microrna mirna miss myocyte nonfailing omnibus overlapping overrepresented repository rising undergo
Tagcloud (Intersection) ?		transcripts