HOXC13 and ELF1

Number of citations: 0 (PubMedID 18692240)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro, in vivo)

		HOXC13	ELF1
Name		homeobox C13	E74 like ETS transcription factor 1
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Hair Follicle Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Nail Development Tongue Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Cytokine Production Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways		None	RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 regulates transcription of genes involved in interleukin signaling
GWAS		A body shape index ( 34021172 ) Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) ( 23648065 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Biliary atresia ( 20460270 ) Blond vs. brown/black hair color ( 30531825 ) Hair shape ( 29220522 ) Hip circumference adjusted for BMI ( 34021172 ) Toenail selenium levels ( 25343990 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-hip ratio ( 20935629 25673412 ) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500 ) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 ) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412 )	Alanine aminotransferase levels ( 34315874 ) Aspartate aminotransferase levels ( 34315874 ) Cervical cancer ( 28806749 ) Crohn's disease ( 23266558 ) Eosinophil percentage of white cells ( 32888494 ) Height ( 31562340 ) Keratoconus ( 33649486 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Neutrophil percentage of white cells ( 32888494 27863252 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Spleen volume ( 34128465 ) Systemic lupus erythematosus ( 33272962 27399966 23273568 21044949 ) Total cholesterol levels ( 30275531 )
Interacting Genes		7 interacting genes: APEX1 ELF1 HNRNPAB HOXC9 MEIS1 NR2E3 RHOXF2	11 interacting genes: HMGA1 HOXC13 NFE2L2 NFKB1 NFYA NFYB NFYC RB1 REL RUNX1 SP1
Entrez ID		3229	1997
HPRD ID		00862	01808
Ensembl ID		ENSG00000123364	ENSG00000120690
Uniprot IDs		P31276	P32519
PDB IDs		Not available	8BZM
GO Terms Enriched among Interactors		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process DNA Binding Chromatin Sequence-specific Double-stranded DNA Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Maintenance Via Base-excision Repair Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Metabolic Process Sequence-specific DNA Binding DNA-(abasic Site) Binding Double-stranded DNA Exodeoxyribonuclease Activity Deoxyribonuclease (pyrimidine Dimer) Activity Positive Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Nucleus Uracil DNA N-glycosylase Activity MRNA Editing Complex DNA-binding Transcription Factor Activity Phosphodiesterase I Activity Cellular Developmental Process Chromosomal 5-methylcytosine DNA Demethylation Pathway Neuron Development Double-stranded DNA 3'-5' DNA Exonuclease Activity Regulation Of Intracellular MRNA Localization Neuronal Ribonucleoprotein Granule RNA-DNA Hybrid Ribonuclease Activity Double-stranded Telomeric DNA Binding Developmental Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cell Growth Involved In Cardiac Muscle Cell Development 3'-5'-DNA Exonuclease Activity	Chromatin Transcription Cis-regulatory Region Binding Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein-DNA Complex Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific CCAAT-binding Factor Complex Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Transcription Regulator Complex Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Binding Cellular Response To Peptide Hormone Stimulus DNA-binding Transcription Factor Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Sequence-specific DNA Binding Nucleoplasm Regulation Of Macromolecule Metabolic Process Response To Peptide Hormone Cellular Response To Angiotensin Cellular Response To Hormone Stimulus Regulation Of Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Developmental Process Response To Angiotensin Nucleus Positive Regulation Of Extracellular Matrix Organization Positive Regulation Of Amide Metabolic Process Positive Regulation Of Angiogenesis Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Vasculature Development Molecular Adaptor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Leukocyte Differentiation