KCTD17 and SPRR2F

Data Source: HiPPIP (Novel)

		KCTD17	SPRR2F
Name		potassium channel tetramerization domain containing 17	small proline rich protein 2F
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cul3-RING Ubiquitin Ligase Complex	Cornified Envelope Cytoplasm Cytosol
	Molecular Function	Protein Binding Identical Protein Binding Cullin Family Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	None
	Biological Process	Cell Projection Organization Endoplasmic Reticulum Calcium Ion Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cilium Assembly Protein Homooligomerization	Epidermis Development Keratinocyte Differentiation Keratinization
Pathways		None	Formation of the cornified envelope
GWAS		Hemoglobin levels ( 33491795 ) Iron status biomarkers (ferritin levels) ( 28334935 ) Liver iron content ( 34128465 ) Mean corpuscular hemoglobin concentration ( 28453575 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Platelet distribution width ( 32888494 ) Red blood cell traits ( 23222517 )	Asthma ( 31619474 ) Asthma or allergic disease (pleiotropy) ( 29785011 )
Novel Interactors		4 novel interactors: ARL8A EGR2 SPHK1 SPRR2F	1 novel interactors: KCTD17
Interacting Genes		23 interacting genes: AQP1 CRK DMC1 FARS2 LAT LNX1 LRRC18 MGAT5B NCK2 NIF3L1 NUDT18 OR51E1 PLCG2 PSMA1 RBX1 RIN3 RWDD4 STK16 SUV39H2 TCHP TINF2 TUBGCP4 UBE2D1	None recorded
Entrez ID		79734	6705
HPRD ID		07764	18699
Ensembl ID		ENSG00000100379	ENSG00000244094
Uniprot IDs		A0A087WX35 Q8N5Z5	Q96RM1
PDB IDs		5A6R	Not available
GO Terms Enriched among Interactors		Signaling Receptor Complex Adaptor Activity Phosphotyrosine Residue Binding	Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Cilium Assembly Cullin Family Protein Binding