SPSB2 and NOS2

Number of citations of the paper that reports this interaction (PMID 20603330)
17

Data Source:
BioGRID (enzymatic study)

		SPSB2	NOS2
Gene Name		splA/ryanodine receptor domain and SOCS box containing 2	nitric oxide synthase 2, inducible
Image
Gene Ontology Annotations	Cellular Component	Cellular_component Cytoplasm	Intracellular Nucleus Cytoplasm Peroxisome Cytosol Cortical Cytoskeleton Perinuclear Region Of Cytoplasm
	Molecular Function	Molecular_function Protein Binding	NADPH-hemoprotein Reductase Activity Nitric-oxide Synthase Activity Receptor Binding Iron Ion Binding Protein Binding Calmodulin Binding FMN Binding Heme Binding Tetrahydrobiopterin Binding Arginine Binding Protein Homodimerization Activity Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Biological_process Protein Ubiquitination Intracellular Signal Transduction	Response To Hypoxia Positive Regulation Of Leukocyte Mediated Cytotoxicity Innate Immune Response In Mucosa Arginine Catabolic Process Superoxide Metabolic Process Nitric Oxide Biosynthetic Process Inflammatory Response Nitric Oxide Mediated Signal Transduction Blood Coagulation Circadian Rhythm Response To Bacterium Negative Regulation Of Gene Expression Peptidyl-cysteine S-nitrosylation Positive Regulation Of Guanylate Cyclase Activity Regulation Of Cell Proliferation Negative Regulation Of Protein Catabolic Process Defense Response To Bacterium Regulation Of Cellular Respiration Negative Regulation Of Blood Pressure Positive Regulation Of Vasodilation Regulation Of Insulin Secretion Defense Response To Gram-negative Bacterium Interaction With Host Positive Regulation Of Killing Of Cells Of Other Organism Oxidation-reduction Process Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Phagosome Maturation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Platelet homeostasis Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Nitric oxide stimulates guanylate cyclase
Drugs			L-Arginine L-Citrulline Miconazole Dexamethasone N,N-dimethylarginine 4r-Fluoro-N6-Ethanimidoyl-L-Lysine 3-Bromo-7-Nitroindazole N-(3-(Aminomethyl)Benzyl)Acetamidine 7-Nitroindazole Ethylisothiourea Thiocoumarin Aminoguanidine S-Ethylisothiourea N-Omega-Propyl-L-Arginine (6r,1\'r,2\'s)-5,6,7,8 Tetrahydrobiopterin Heme 6-Nitroindazole N-Omega-Hydroxy-L-Arginine 7,8-Dihydro-L-Biopterin N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine L-Thiocitrulline 7,8-Dihydrobiopterin 5-Nitroindazole 5-(4\'-AMINO-1\'-ETHYL-5\',8\'-DIFLUORO-1\'H-SPIRO[PIPERIDINE-4,2\'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE 4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile (2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine (3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE (3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINE 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE 1-(6-CYANO-3-PYRIDYLCARBONYL)-5\',8\'-DIFLUOROSPIRO[PIPERIDINE-4,2\'(1\'H)-QUINAZOLINE]-4\'-AMINE 4-(1H-IMIDAZOL-1-YL)PHENOL 1-[4-(AMINOMETHYL)BENZOYL]-5\'-FLUORO-1\'H-SPIRO[PIPERIDINE-4,2\'-QUINAZOLIN]-4\'-AMINE Triflusal
Diseases
GWAS			Crohn's disease ( 23128233) Psoriasis ( 20953189)
Protein-Protein Interactions		6 interactors: APP DDX4 GALNT15 NOS2 PAWR PRMT1	11 interactors: ACTB ACTN4 CAV1 PEX5 RAC1 RAC2 SLC9A3R1 SPSB1 SPSB2 SPSB4 SRC
Entrez ID		84727	4843
HPRD ID		13610	01225
Ensembl ID		ENSG00000111671	ENSG00000007171
Uniprot IDs		B7Z4W1 Q99619	P35228
PDB IDs		3EMW	1NSI 2LL6 2NSI 3E7G 3EJ8 3HR4 4NOS
Enriched GO Terms of Interacting Partners?		Sexual Reproduction Reproduction Reproductive Process Spermatogenesis Male Gamete Generation Gamete Generation Cell Development Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Synaptic Growth At Neuromuscular Junction Negative Regulation Of Cell Differentiation Collateral Sprouting In Absence Of Injury Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Negative Regulation Of Megakaryocyte Differentiation Collateral Sprouting Axon Midline Choice Point Recognition Peptidyl-cysteine S-nitrosylation Interleukin-2 Biosynthetic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Germ-line Stem Cell Maintenance Axon Choice Point Recognition Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Regulation Of Amyloid Precursor Protein Biosynthetic Process Regulation Of Translation Interleukin-2 Production Arginine Catabolic Process Single Organism Reproductive Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Neuron Remodeling Positive Regulation Of Killing Of Cells Of Other Organism Regulation Of Killing Of Cells Of Other Organism Positive Regulation Of Guanylate Cyclase Activity Regulation Of Immune System Process Peptidyl-arginine N-methylation Regulation Of Cellular Respiration Developmental Process Protein Metabolic Process Histone H4-R3 Methylation Positive Regulation Of Glycoprotein Biosynthetic Process Negative Regulation Of Immune System Process Nitric Oxide Biosynthetic Process Organelle Organization Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Glycoprotein Metabolic Process RNA Metabolic Process Cellular Protein Modification Process Nitric Oxide Mediated Signal Transduction Negative Regulation Of B Cell Proliferation Innate Immune Response In Mucosa Histone Arginine Methylation	Blood Coagulation Hemostasis Platelet Activation Regulation Of Body Fluid Levels Vascular Endothelial Growth Factor Receptor Signaling Pathway Wound Healing Tissue Remodeling Cellular Component Assembly Regulation Of Cellular Component Movement Response To Wounding Bone Resorption Tissue Homeostasis Regulation Of Endocytosis Cell-cell Junction Organization Bone Remodeling Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Protein Homooligomerization Signal Transduction Multicellular Organismal Homeostasis Actin Cytoskeleton Organization Intracellular Signal Transduction Signaling T Cell Costimulation Actin Filament-based Process Cell Communication Negative Regulation Of Protein Oligomerization Cell Activation Locomotion Actin Filament Organization Regulation Of Hydrogen Peroxide Metabolic Process Organelle Organization Ephrin Receptor Signaling Pathway Regulation Of Respiratory Burst Homeostatic Process Positive Regulation Of Cellular Component Movement Regulation Of Proton Transport Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Anoikis Regulation Of Vesicle-mediated Transport Regulation Of Cell Projection Assembly Movement Of Cell Or Subcellular Component Axon Guidance Membrane Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Lamellipodium Organization Regulation Of Anoikis Positive Regulation Of Immune System Process Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity
Tagcloud ?			17q 2q35 5p 6p 9p bcg candidates demonstration dichotomy exacerbation examines helper histocompatibility il4 immunology inbred ity leishmania leishmanial leishmaniasis lsh mexicana mip1 nramp1 parasites pleiotropic positionally reflecting sigje
Tagcloud (Difference) ?			17q 2q35 5p 6p 9p bcg candidates demonstration dichotomy exacerbation examines helper histocompatibility il4 immunology inbred ity leishmania leishmanial leishmaniasis lsh mexicana mip1 nramp1 parasites pleiotropic positionally reflecting sigje
Tagcloud (Intersection) ?