SPSB2 and GALNT15

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SPSB2	GALNT15
Description		splA/ryanodine receptor domain and SOCS box containing 2	polypeptide N-acetylgalactosaminyltransferase 15
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Golgi Membrane Golgi Apparatus Membrane Transport Vesicle
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Polypeptide N-acetylgalactosaminyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Carbohydrate Binding Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Protein Glycosylation Protein O-linked Glycosylation Protein O-linked Glycosylation Via N-acetyl-galactosamine
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	O-linked glycosylation of mucins
Drugs
Diseases
GWAS		Colorectal cancer ( 26965516) Refractive error ( 32231278)	Numerical cognitive ability ( 31620175) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		11 interacting genes: APP DDX4 FNDC3B GALNT15 NOS2 NRF1 PRMT1 RECK SMARCD1 TRIM55 TRIM63	18 interacting genes: CD200R1 CD79A CISD2 EVI2B FCRL6 FFAR2 FNDC9 GOLM1 IL27RA MR1 MUC1 PDCD1LG2 PDZK1IP1 SLC30A2 SLC7A1 SPSB2 SYNPR TMEM179B
Entrez ID		84727	117248
HPRD ID		13610	13563
Ensembl ID		ENSG00000111671	ENSG00000131386
Uniprot IDs		Q99619	C9JGI4 Q4G146 Q8N3T1
PDB IDs		3EMW 5XN3 6DN5 6DN6 6JKJ 6JWM 6JWN 6KEY
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex PTB Domain Binding Response To Interleukin-1 Innate Immune Response Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cellular Response To Oxygen-containing Compound Chromatin Organization Epigenetic Regulation Of Gene Expression Defense Response To Symbiont Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Defense Response To Other Organism Positive Regulation Of Interleukin-6 Production Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Defense Response To Gram-negative Bacterium Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Double-strand Break Repair GATOR1 Complex Binding Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Regulation Of Establishment Of Blood-brain Barrier Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Peptidase Inhibitor Activity Growth Factor Receptor Binding	Membrane Plasma Membrane External Side Of Plasma Membrane Negative Regulation Of T Cell Migration Positive Regulation Of Immune System Process Regulation Of Immune System Process Negative Regulation Of Lymphocyte Migration Immune Response Positive Regulation Of Neutrophil Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Negative Regulation Of T Cell Extravasation Negative Regulation Of Mononuclear Cell Migration Regulation Of T Cell Migration Negative Regulation Of Interleukin-6 Production Transmembrane Signaling Receptor Activity Negative Regulation Of Leukocyte Migration
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