MED10 and NAP1L1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		MED10	NAP1L1
Gene Name		mediator complex subunit 10	nucleosome assembly protein 1-like 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mediator Complex	Nucleus Membrane Melanosome
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity Protein Binding	Protein Binding Poly(A) RNA Binding
	Biological Process	Transcription Initiation From RNA Polymerase II Promoter Gene Expression Stem Cell Maintenance Positive Regulation Of Transcription From RNA Polymerase II Promoter	DNA Replication Nucleosome Assembly Positive Regulation Of Cell Proliferation
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		7 interactors: ESR1 ESR2 HNF4A KDM4B MOB4 NAP1L1 PEBP1	14 interactors: CREBBP CSNK2B DLST EP300 FSD1 HBA1 MED10 NR2F6 PHB POT1 SP1 TERF1 TP53 TPX2
Entrez ID		84246	4673
HPRD ID		14680	01248
Ensembl ID		ENSG00000133398	ENSG00000187109
Uniprot IDs		Q9BTT4	B3KV44 B7Z4K9 B7Z9C2 F8W543 P55209
PDB IDs
Enriched GO Terms of Interacting Partners?		Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Vagina Development Uterus Development Intracellular Estrogen Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Female Genitalia Development Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Prostate Gland Epithelium Morphogenesis Prostate Gland Morphogenesis Sex Differentiation Genitalia Development Cellular Response To Organic Cyclic Compound Ovarian Follicle Development Prostate Gland Development Cellular Response To Lipid Intracellular Steroid Hormone Receptor Signaling Pathway Response To Steroid Hormone Ovulation Cycle Process Female Gonad Development Regulation Of Cell Proliferation Ovulation Cycle Cellular Response To Hormone Stimulus Development Of Primary Female Sexual Characteristics Chromatin Organization Prostate Epithelial Cord Elongation Negative Regulation Of Cell Growth Developmental Process Involved In Reproduction Gland Morphogenesis Positive Regulation Of Cholesterol Homeostasis Cellular Macromolecule Biosynthetic Process Response To Lipid Regulation Of Growth Hormone Receptor Signaling Pathway Epithelial Cell Maturation Involved In Prostate Gland Development Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Hormone-mediated Apoptotic Signaling Pathway Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Epithelial Cell Development Response To Organic Cyclic Compound Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Branch Elongation Involved In Mammary Gland Duct Branching Antral Ovarian Follicle Growth Gonad Development Response To Hormone Development Of Primary Sexual Characteristics Negative Regulation Of Growth	N-terminal Peptidyl-lysine Acetylation Mitotic Cell Cycle Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of DNA Replication Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomerase Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation Of Macromolecule Biosynthetic Process Chromosome Organization Positive Regulation Of Cellular Biosynthetic Process Positive Regulation By Host Of Viral Transcription Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Via Telomerase N-terminal Protein Amino Acid Acetylation Negative Regulation Of DNA Metabolic Process Rhythmic Process Cellular Response To Hypoxia Positive Regulation Of Metabolic Process Cellular Response To Decreased Oxygen Levels Mitotic Cell Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Telomerase Activity Cellular Response To Oxygen Levels Chromatin Organization Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of DNA Replication Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Telomere Maintenance Positive Regulation Of Transcription, DNA-templated Cell Cycle Regulation Of Androgen Receptor Signaling Pathway Notch Signaling Pathway Cellular Nitrogen Compound Metabolic Process RNA-dependent DNA Replication Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Cellular Metabolic Process Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of DNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Photoperiodism Entrainment Of Circadian Clock N-terminal Protein Amino Acid Modification Organelle Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Gene Expression
Tagcloud ?		adapted bipolar colonies constituent desired ends front glycogen gsk3beta inositol integrations intergenic linc lithium mood msi2 mutated neuroblastoma pms1 presumed proliferate race readily salts screen stabilizing sy5y trapped variously	arrays asf1a assembles assembly breaks caf chaperones clamp coupled elucidating faithfully h2a h2b loader nascent nucleosomal nucleosome nucleosomes p48 packaging pcna progress recapitulates replication replicative reproduces rfc strand synthesized
Tagcloud (Difference) ?		adapted bipolar colonies constituent desired ends front glycogen gsk3beta inositol integrations intergenic linc lithium mood msi2 mutated neuroblastoma pms1 presumed proliferate race readily salts screen stabilizing sy5y trapped variously	arrays asf1a assembles assembly breaks caf chaperones clamp coupled elucidating faithfully h2a h2b loader nascent nucleosomal nucleosome nucleosomes p48 packaging pcna progress recapitulates replication replicative reproduces rfc strand synthesized
Tagcloud (Intersection) ?