MED10 and FUCA1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MED10	FUCA1
Description		mediator complex subunit 10	alpha-L-fucosidase 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex Core Mediator Complex	Extracellular Region Cytoplasm Lysosome Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity	Alpha-L-fucosidase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Carbohydrate Metabolic Process Fucose Metabolic Process Lipid Metabolic Process Glycoside Catabolic Process Glycolipid Catabolic Process
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Neutrophil degranulation Reactions specific to the complex N-glycan synthesis pathway
Drugs
Diseases			Fucosidosis
GWAS			Arterial stiffness index ( 31235810) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		13 interacting genes: ABI2 ARHGDIG CEBPA ESR1 ESR2 FUCA1 HNF4A KDM4B MOB4 NAP1L1 PEBP1 SYCE1L TRIM45	8 interacting genes: APP BARD1 CIB1 MED10 OGT PAXIP1 UBQLN2 VAV2
Entrez ID		84246	2517
HPRD ID		14680	01974
Ensembl ID		ENSG00000133398	ENSG00000179163
Uniprot IDs		Q9BTT4	P04066
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH	7PLS 7PM4
Enriched GO Terms of Interacting Partners?		Nuclear Estrogen Receptor Activity Nuclear Receptor Activity Estrogen Response Element Binding Chromatin Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Steroid Binding Sequence-specific DNA Binding Chromatin Binding Cellular Response To Estradiol Stimulus Intracellular Receptor Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Ornithine Metabolic Process Intracellular Signal Transduction DNA-binding Transcription Factor Activity Response To Vitamin B2 C/EBP Complex Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Alpha-L-fucosidase Activity Zonula Adherens Assembly	Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Positive Regulation Of Calcium-mediated Signaling Regulation Of Glycolytic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Chromatin Organization Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Localization Negative Regulation Of MRNA 3'-end Processing Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Male Germ Cell Proliferation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of ATP Metabolic Process Intracellular Signal Transduction Regulation Of Receptor Internalization Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Proteolysis Regulation Of Signal Transduction Regulation Of Purine Nucleotide Metabolic Process Regulation Of DNA-templated Transcription Initiation Acetylcholine Receptor Activator Activity Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Regulation Of Response To Endoplasmic Reticulum Stress Macromolecule Metabolic Process Regulation Of Calcium-mediated Signaling Lipoprotein Particle Positive Regulation Of Protein Import Regulation Of Intracellular Signal Transduction Response To Radiation Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity
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