MED10 and TRIM45

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MED10	TRIM45
Description		mediator complex subunit 10	tripartite motif containing 45
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex Core Mediator Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Intercellular Bridge
	Molecular Function	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Inflammatory Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Inflammatory Response Bone Development Protein K48-linked Ubiquitination
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Interferon gamma signaling
Drugs
Diseases
GWAS
Interacting Genes		13 interacting genes: ABI2 ARHGDIG CEBPA ESR1 ESR2 FUCA1 HNF4A KDM4B MOB4 NAP1L1 PEBP1 SYCE1L TRIM45	18 interacting genes: CDC42 GABARAPL2 MED10 MEOX2 PTGES3L-AARSD1 TAB2 TAX1BP1 TEPSIN TFIP11 UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 ZMYND19
Entrez ID		84246	80263
HPRD ID		14680	15562
Ensembl ID		ENSG00000133398	ENSG00000134253
Uniprot IDs		Q9BTT4	Q9H8W5
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH	2DS4
Enriched GO Terms of Interacting Partners?		Nuclear Estrogen Receptor Activity Nuclear Receptor Activity Estrogen Response Element Binding Chromatin Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Steroid Binding Sequence-specific DNA Binding Chromatin Binding Cellular Response To Estradiol Stimulus Intracellular Receptor Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Ornithine Metabolic Process Intracellular Signal Transduction DNA-binding Transcription Factor Activity Response To Vitamin B2 C/EBP Complex Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Alpha-L-fucosidase Activity Zonula Adherens Assembly	Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Protein K63-linked Ubiquitination Protein Modification Process Protein Monoubiquitination ISG15 Transferase Activity Ubiquitin-dependent Protein Catabolic Process ISG15-protein Conjugation Modification-dependent Protein Catabolic Process Nucleotide Binding Ubiquitin Protein Ligase Activity Protein Metabolic Process ATP Binding Proteolysis Involved In Protein Catabolic Process Protein Autoubiquitination Transferase Activity Protein K6-linked Ubiquitination Catabolic Process Macromolecule Catabolic Process Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Proteolysis Coated Vesicle Membrane GBD Domain Binding Storage Vacuole Positive Regulation Of Reciprocal Meiotic Recombination Protein Localization To Phagocytic Vesicle Spliceosomal Complex Disassembly Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Cell Cycle Process Negative Regulation Of Macromolecule Metabolic Process
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