MED10 and KDM4B

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		MED10	KDM4B
Description		mediator complex subunit 10	lysine demethylase 4B
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex Core Mediator Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity	Zinc Ion Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3K9 Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3K36 Demethylase Activity Histone H3K9me2/H3K9me3 Demethylase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Chromatin Organization Chromatin Remodeling Brain Development Regulation Of Gene Expression
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	HDMs demethylate histones Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Estrogen-dependent gene expression
Drugs
Diseases
GWAS			Granulocyte percentage of myeloid white cells ( 27863252) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Periodontitis (CDC/AAP) ( 24024966) Pulse pressure ( 30578418) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549) Urate levels ( 31578528) Walking pace ( 33128006)
Interacting Genes		13 interacting genes: ABI2 ARHGDIG CEBPA ESR1 ESR2 FUCA1 HNF4A KDM4B MOB4 NAP1L1 PEBP1 SYCE1L TRIM45	2 interacting genes: H3-5 MED10
Entrez ID		84246	23030
HPRD ID		14680	11056
Ensembl ID		ENSG00000133398	ENSG00000127663
Uniprot IDs		Q9BTT4	A0A0C4DFL8 F5GX28 O94953
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH	4LXL 4UC4 7JM5 9H44
Enriched GO Terms of Interacting Partners?		Nuclear Estrogen Receptor Activity Nuclear Receptor Activity Estrogen Response Element Binding Chromatin Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Steroid Binding Sequence-specific DNA Binding Chromatin Binding Cellular Response To Estradiol Stimulus Intracellular Receptor Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Ornithine Metabolic Process Intracellular Signal Transduction DNA-binding Transcription Factor Activity Response To Vitamin B2 C/EBP Complex Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Alpha-L-fucosidase Activity Zonula Adherens Assembly
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