FAM175A and BRE

Number of citations of the paper that reports this interaction (PMID 19261748)
44

Data Source:
BioGRID (affinity chromatography technology, pull down)

		FAM175A	BRE
Gene Name		family with sequence similarity 175, member A	brain and reproductive organ-expressed (TNFRSF1A modulator)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus BRCA1-A Complex	Nuclear Ubiquitin Ligase Complex Nucleus Cytoplasm BRCA1-A Complex BRISC Complex
	Molecular Function	Protein Binding Polyubiquitin Binding	Peroxisome Targeting Sequence Binding Tumor Necrosis Factor Receptor Binding Protein Binding Polyubiquitin Binding
	Biological Process	Double-strand Break Repair Response To Ionizing Radiation Chromatin Modification G2 DNA Damage Checkpoint Positive Regulation Of DNA Repair	Double-strand Break Repair Apoptotic Process Cellular Response To DNA Damage Stimulus Signal Transduction Response To Ionizing Radiation Chromatin Modification G2 DNA Damage Checkpoint Positive Regulation Of DNA Repair
Pathways
Drugs
Diseases
GWAS		Upper aerodigestive tract cancers ( 21437268)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		5 interactors: BRCA1 BRE SUMO2 UBC UIMC1	7 interactors: BABAM1 FAM175A GFI1B NCOA3 SUMO2 UBC UBE2D1
Entrez ID		84142	9577
HPRD ID		08584	08498
Ensembl ID		ENSG00000163322	ENSG00000158019
Uniprot IDs		D6REL5 Q6UWZ7	Q9NXR7
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Damage Checkpoint G2 DNA Damage Checkpoint Positive Regulation Of DNA Repair Cell Cycle Checkpoint Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Regulation Of Response To DNA Damage Stimulus DNA Repair Response To Ionizing Radiation Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of Cellular Metabolic Process Cell Cycle Process DNA Metabolic Process Response To Abiotic Stimulus Cell Cycle Positive Regulation Of Metabolic Process Response To Radiation Cellular Response To Stress Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle Arrest Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Cellular Protein Catabolic Process Protein Polyubiquitination Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Histone H2A K63-linked Deubiquitination Apoptotic Process Intracellular Receptor Signaling Pathway Regulation Of Protein Ubiquitination Programmed Cell Death Cell Death Death Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Indole-3-methanol Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Centriole Replication	Cell Cycle Checkpoint Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Positive Regulation Of Cellular Metabolic Process Chromatin Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Protein Catabolic Process Chromatin Organization Positive Regulation Of DNA Repair G2 DNA Damage Checkpoint Positive Regulation Of Metabolic Process Positive Regulation Of Proteolysis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Chromosome Organization Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA Repair Regulation Of DNA-templated Transcription In Response To Stress Cell Cycle Process Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Response To Abiotic Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Nucleobase-containing Compound Metabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Cycle Regulation Of Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Protein Ubiquitination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Stress DNA Repair Cellular Nitrogen Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus
Tagcloud ?			cdna cerebellar damaging encodes fas gives homologous hybrid immunoprecipitation interacted irradiation juxtamembrane kb kilodaltons library modulate neurotrophin nfkappab organs p55 p75 reproductive responsive rise screen tnf uv verified yeast
Tagcloud (Difference) ?			cdna cerebellar damaging encodes fas gives homologous hybrid immunoprecipitation interacted irradiation juxtamembrane kb kilodaltons library modulate neurotrophin nfkappab organs p55 p75 reproductive responsive rise screen tnf uv verified yeast
Tagcloud (Intersection) ?