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FAM175A and BRCA1
Number of citations of the paper that reports this interaction (PMID
17525340
)
184
Data Source:
HPRD
(in vitro)
FAM175A
BRCA1
Gene Name
family with sequence similarity 175, member A
breast cancer 1, early onset
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
BRCA1-A Complex
Ubiquitin Ligase Complex
Condensed Nuclear Chromosome
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Plasma Membrane
Gamma-tubulin Ring Complex
Ribonucleoprotein Complex
BRCA1-BARD1 Complex
Protein Complex
BRCA1-A Complex
Molecular Function
Protein Binding
Polyubiquitin Binding
DNA Binding
Damaged DNA Binding
Transcription Coactivator Activity
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Tubulin Binding
Ligase Activity
Enzyme Binding
Ubiquitin Protein Ligase Binding
Transcription Regulatory Region DNA Binding
Androgen Receptor Binding
Biological Process
Double-strand Break Repair
Response To Ionizing Radiation
Chromatin Modification
G2 DNA Damage Checkpoint
Positive Regulation Of DNA Repair
Double-strand Break Repair Via Homologous Recombination
DNA Replication
DNA Repair
Postreplication Repair
Double-strand Break Repair
Regulation Of Gene Expression By Genetic Imprinting
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transcription From RNA Polymerase III Promoter
Fatty Acid Biosynthetic Process
Apoptotic Process
Cellular Response To DNA Damage Stimulus
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Chromosome Segregation
Centrosome Cycle
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Dosage Compensation By Inactivation Of X Chromosome
Response To Ionizing Radiation
Positive Regulation Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Protein Ubiquitination
Androgen Receptor Signaling Pathway
Positive Regulation Of Protein Ubiquitination
G2 DNA Damage Checkpoint
Positive Regulation Of Histone Acetylation
Negative Regulation Of Histone Acetylation
Regulation Of Cell Proliferation
Regulation Of Apoptotic Process
Chordate Embryonic Development
Response To Estrogen
Regulation Of DNA Methylation
Negative Regulation Of Fatty Acid Biosynthetic Process
Positive Regulation Of DNA Repair
Positive Regulation Of Angiogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Centriole Replication
Positive Regulation Of Histone H3-K4 Methylation
Negative Regulation Of Histone H3-K4 Methylation
Negative Regulation Of Histone H3-K9 Methylation
Positive Regulation Of Histone H3-K9 Methylation
Protein Autoubiquitination
Positive Regulation Of Histone H4-K20 Methylation
Positive Regulation Of Cell Cycle Arrest
Cellular Response To Tumor Necrosis Factor
Cellular Response To Indole-3-methanol
Protein K6-linked Ubiquitination
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Histone H3-K9 Acetylation
Positive Regulation Of Histone H4-K16 Acetylation
Pathways
ATM mediated phosphorylation of repair proteins
Meiotic recombination
Fanconi Anemia pathway
ATM mediated response to DNA double-strand break
Homologous Recombination Repair
Meiotic synapsis
Homologous recombination repair of replication-independent double-strand breaks
Recruitment of repair and signaling proteins to double-strand breaks
Double-Strand Break Repair
Drugs
Diseases
GWAS
Upper aerodigestive tract cancers (
21437268
)
Protein-Protein Interactions
5 interactors:
BRCA1
BRE
SUMO2
UBC
UIMC1
312 interactors:
ABL1
ABLIM3
ACACA
ACTG1
ACTN3
AHR
AKT1
ALDH1A1
ALS2CR11
ANTXR1
AP1M1
APLP2
AR
ARNT
ASH2L
ATF1
ATM
ATP1B1
ATP1B3
ATR
ATRIP
AURKA
AURKC
BABAM1
BAP1
BARD1
BRAP
BRAT1
BRCA2
BRCC3
BRIP1
BRSK1
C22orf29
CABYR
CASP3
CCDC120
CCNA1
CCNA2
CCNB1
CCND1
CDK1
CDK16
CDK2
CDK4
CDK5
CDK7
CDK9
CDKN2D
CEP57L1
CHEK1
CHEK2
CLSPN
CNRIP1
CNTLN
CNTN4
COL1A1
COMMD1
CREBBP
CRIPAK
CRY2
CRYZL1
CSNK1D
CSNK2A1
CSNK2B
CSTF1
CTBP1
CTCFL
CTNNB1
CUBN
CWF19L2
DALRD3
DBF4
DCLRE1C
DCN
DDX24
DES
DHPS
DHX9
DNAJA1
DNAJA3
DNAJB1
DNHD1
DYNC1H1
E2F1
E2F4
EED
EIF3B
EIF4A2
EIF5B
ELK1
ELK4
ENO1
EP300
ERCC6
ERO1LB
ESR1
ETS1
ETV5
EZH2
FAM161A
FAM175A
FAM184A
FANCA
FANCD2
FHL2
FLI1
FXR2
GCC1
GFI1B
GGN
GOLGA8DP
GTF3C4
GUSBP1
H2AFX
H2AFY
HDAC1
HDAC2
HECTD3
HERC2
HGF
HIBADH
HIST1H2AB
HIST2H2AC
HIVEP1
HNRNPC
HNRNPD
HORMAD1
HSPA14
HSPA8
HSPD1
IFI16
INPP1
ITIH5
JAK1
JAK2
JUN
JUNB
JUND
JUP
KAT2A
KAT5
KDM1A
KIF1B
KPNA2
KPNA6
LCK
LCMT1
LDHC
LMNTD1
LMO4
LONRF1
MAN2C1
MAP3K1
MAP3K14
MAP3K3
MAP4K4
MARCKSL1
MDC1
MED1
MED21
MID2
MLH1
MNAT1
MRE11A
MSH2
MSH3
MSH6
MYC
MYOZ1
NBN
NCOA2
NCOA3
ND1
NELFB
NFKB1
NFYA
NKAPL
NMI
NPC2
NRIP1
NUFIP1
NUP153
OBSCN
OLA1
PEG3
PEX5
PGR
PHF12
PIAS1
PIAS4
PIK3R1
PILRB
PISD
POLR2A
POLR2H
POLR2K
POM121
POMGNT1
POU2F1
PPHLN1
PPP1CA
PPP1CB
PPP1R13B
PPP2R5C
PREP
PRKAG3
PRKDC
PRMT1
PRPF3
PSAP
PSMA6
PSMD9
PSMG1
RAD51
RANBP9
RB1
RBBP4
RBBP7
RBBP8
RBL1
RBL2
RBX1
RELA
RFC1
RNF216
RPGRIP1
RPL31
RTKN2
RUNX1T1
RWDD2B
RWDD4
SDK2
SETX
SHFM1
SMAD2
SMAD3
SMAD4
SMARCA2
SMARCA4
SMC1A
SNRNP200
SNX3
SNX6
SOX30
SP1
SPATA4
SRC
SSFA2
SSX2IP
STAC2
STAT1
STAT3
STAT5A
SUMO1
SYT6
TARS
TATDN2
TCEA2
TCEANC
TCEB3
TCTEX1D2
TEX101
THOC3
TLE4
TMPRSS12
TNS2
TOP2A
TP53
TP53BP1
TPTE2
TRIM24
TRIM46
TRIM74
TRRAP
TSEN54
TSGA10IP
TUBA4A
TUBB
TUBG1
TULP2
TXLNA
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2J1
UBE2K
UBE2L3
UBE2N
UBE2T
UBE2W
UBE3A
UBXN1
USF2
USH2A
USP2
VCP
WBSCR16
WDR6
WNT2B
XIAP
XRCC1
XRCC5
YY1
ZNF280D
ZNF350
ZNF423
ZSCAN21
Entrez ID
84142
672
HPRD ID
08584
00218
Ensembl ID
ENSG00000163322
ENSG00000012048
Uniprot IDs
D6REL5
Q6UWZ7
E9PFC7
E9PFZ0
P38398
Q1RMC1
PDB IDs
1JM7
1JNX
1N5O
1OQA
1T15
1T29
1T2U
1T2V
1Y98
2ING
3COJ
3K0H
3K0K
3K15
3K16
3PXA
3PXB
3PXC
3PXD
3PXE
Enriched GO Terms of Interacting Partners
?
DNA Damage Checkpoint
G2 DNA Damage Checkpoint
Positive Regulation Of DNA Repair
Cell Cycle Checkpoint
Regulation Of DNA Repair
Positive Regulation Of Response To DNA Damage Stimulus
Regulation Of Response To DNA Damage Stimulus
DNA Repair
Response To Ionizing Radiation
Positive Regulation Of DNA Metabolic Process
Double-strand Break Repair
Cellular Response To DNA Damage Stimulus
Positive Regulation Of Cellular Metabolic Process
Cell Cycle Process
DNA Metabolic Process
Response To Abiotic Stimulus
Cell Cycle
Positive Regulation Of Metabolic Process
Response To Radiation
Cellular Response To Stress
Positive Regulation Of Cell Cycle Arrest
DNA Damage Response, Signal Transduction By P53 Class Mediator
Signal Transduction In Response To DNA Damage
Protein Modification By Small Protein Conjugation
Regulation Of Cell Cycle Arrest
Positive Regulation Of Histone H4-K20 Methylation
Positive Regulation Of Histone H4-K16 Acetylation
Signal Transduction By P53 Class Mediator
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Histone H3-K9 Acetylation
Positive Regulation Of Cellular Protein Catabolic Process
Protein Polyubiquitination
Positive Regulation Of Histone H4 Acetylation
Negative Regulation Of Histone H3-K4 Methylation
Histone H2A K63-linked Deubiquitination
Apoptotic Process
Intracellular Receptor Signaling Pathway
Regulation Of Protein Ubiquitination
Programmed Cell Death
Cell Death
Death
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Cell Cycle Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Protein Metabolic Process
Cellular Response To Indole-3-methanol
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Centriole Replication
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Heterocycle Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Response To Stress
Positive Regulation Of Metabolic Process
Nitrogen Compound Metabolic Process
Cellular Response To DNA Damage Stimulus
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Gene Expression
Cell Cycle
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
DNA Repair
Cell Cycle Process
Regulation Of Cell Cycle
Cellular Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Regulation Of Nitrogen Compound Metabolic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
RNA Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Response To Abiotic Stimulus
Transcription, DNA-templated
Gene Expression
Regulation Of Gene Expression
DNA Metabolic Process
Transcription From RNA Polymerase II Promoter
RNA Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Response To Stress
Cell Cycle Checkpoint
Negative Regulation Of Cell Cycle
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Chromosome Organization
Negative Regulation Of Biosynthetic Process
Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Mitotic Cell Cycle
Cellular Response To Stimulus
DNA Damage Checkpoint
Negative Regulation Of RNA Biosynthetic Process
Biosynthetic Process
Organelle Organization
Response To Stimulus
Tagcloud
?
1b
53bp1
activators
associates
binds
brct
cbp
cip1
domain
emphasized
hat
homology
inherited
link
manners
maps
ovarian
p100
p110
p21waf1
p53
promoters
splice
stimulate
stimulates
suppression
transactivation
Tagcloud (Difference)
?
1b
53bp1
activators
associates
binds
brct
cbp
cip1
domain
emphasized
hat
homology
inherited
link
manners
maps
ovarian
p100
p110
p21waf1
p53
promoters
splice
stimulate
stimulates
suppression
transactivation
Tagcloud (Intersection)
?