FAM175A and UIMC1

Number of citations of the paper that reports this interaction (PMID 17525340)
184

Data Source:
HPRD (in vivo, in vitro)

		FAM175A	UIMC1
Gene Name		family with sequence similarity 175, member A	ubiquitin interaction motif containing 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus BRCA1-A Complex	Nucleus BRCA1-A Complex
	Molecular Function	Protein Binding Polyubiquitin Binding	Protein Binding Histone Binding Retinoid X Receptor Binding K63-linked Polyubiquitin Binding
	Biological Process	Double-strand Break Repair Response To Ionizing Radiation Chromatin Modification G2 DNA Damage Checkpoint Positive Regulation Of DNA Repair	Double-strand Break Repair Transcription, DNA-templated Response To Ionizing Radiation G2 DNA Damage Checkpoint Positive Regulation Of DNA Repair Negative Regulation Of Transcription, DNA-templated Histone H2A K63-linked Deubiquitination
Pathways
Drugs
Diseases
GWAS		Upper aerodigestive tract cancers ( 21437268)	Activated partial thromboplastin time ( 22703881) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 22267201)
Protein-Protein Interactions		5 interactors: BRCA1 BRE SUMO2 UBC UIMC1	14 interactors: ATP8A2 BABAM1 BRCC3 CEP57 ESR1 FAM175A FANCG HIST2H2AC INO80B KIAA0368 MDC1 NR6A1 SKIL TP53
Entrez ID		84142	51720
HPRD ID		08584	11482
Ensembl ID		ENSG00000163322	ENSG00000087206
Uniprot IDs		D6REL5 Q6UWZ7	Q96RL1
PDB IDs			2RR9
Enriched GO Terms of Interacting Partners?		DNA Damage Checkpoint G2 DNA Damage Checkpoint Positive Regulation Of DNA Repair Cell Cycle Checkpoint Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Regulation Of Response To DNA Damage Stimulus DNA Repair Response To Ionizing Radiation Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of Cellular Metabolic Process Cell Cycle Process DNA Metabolic Process Response To Abiotic Stimulus Cell Cycle Positive Regulation Of Metabolic Process Response To Radiation Cellular Response To Stress Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle Arrest Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Cellular Protein Catabolic Process Protein Polyubiquitination Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Histone H2A K63-linked Deubiquitination Apoptotic Process Intracellular Receptor Signaling Pathway Regulation Of Protein Ubiquitination Programmed Cell Death Cell Death Death Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Indole-3-methanol Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Centriole Replication	Cell Cycle Checkpoint Double-strand Break Repair DNA Repair DNA Damage Checkpoint Cell Cycle Process Positive Regulation Of Response To DNA Damage Stimulus Response To Radiation Cellular Response To DNA Damage Stimulus Cell Cycle Positive Regulation Of DNA Repair Regulation Of Response To DNA Damage Stimulus DNA Metabolic Process G2 DNA Damage Checkpoint Response To Ionizing Radiation Chromatin Organization Regulation Of DNA Repair Cellular Response To Stress Organelle Organization Chromosome Organization Chromatin Modification Response To Abiotic Stimulus Nucleobase-containing Compound Metabolic Process Protein K63-linked Deubiquitination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Multicellular Organismal Reproductive Process Positive Regulation Of DNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Multicellular Organism Reproduction Protein Import Into Nucleus, Translocation Cellular Response To Stimulus Response To Stimulus Transcription Initiation From RNA Polymerase II Promoter Response To X-ray Spermatogenesis Male Gamete Generation Nitrogen Compound Metabolic Process Reproduction DNA-templated Transcription, Initiation Single Organism Reproductive Process Gamete Generation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Antibiotic Reproductive Process Rhythmic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ovarian Follicle Development Sexual Reproduction Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process
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