KDM5D and PCGF6

Number of citations of the paper that reports this interaction (PMID 17320162)
64

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		KDM5D	PCGF6
Gene Name		lysine (K)-specific demethylase 5D	polycomb group ring finger 6
Image
Gene Ontology Annotations	Cellular Component	Cellular_component Nucleoplasm	Nucleus PcG Protein Complex PRC1 Complex
	Molecular Function	DNA Binding Zinc Ion Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Histone Demethylase Activity (H3-K4 Specific)	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding
	Biological Process	Chromatin Organization Histone H3-K4 Demethylation Oxidation-reduction Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated
Pathways		Chromatin modifying enzymes Chromatin organization HDMs demethylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: HIST3H3 PCGF6	16 interactors: BMI1 CBX6 CBX7 CBX8 CDK7 E2F6 HIST3H3 KDM5D PEX10 RAD18 RING1 RNF2 SS18L1 UBE2U USP2 USP21
Entrez ID		8284	84108
HPRD ID		02464	07427
Ensembl ID		ENSG00000012817	ENSG00000156374
Uniprot IDs		B4E1Y0 Q9BY66	Q9BYE7
PDB IDs		2E6R 2YQE	2DJB
Enriched GO Terms of Interacting Partners?			Chromatin Modification Chromosome Organization Chromatin Organization Histone Ubiquitination Histone Modification Organelle Organization Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Protein Ubiquitination Nitrogen Compound Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Protein Modification Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Histone H2A Monoubiquitination Macromolecule Biosynthetic Process Cellular Metabolic Process Histone H2A Ubiquitination Regulation Of Gene Expression Histone Monoubiquitination Cellular Protein Metabolic Process Biosynthetic Process Protein Monoubiquitination Regulation Of Metabolic Process DNA Metabolic Process Anterior/posterior Pattern Specification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Metabolic Process Histone H2A-K119 Monoubiquitination Metabolic Process Positive Regulation Of Immature T Cell Proliferation In Thymus
Tagcloud ?		4b beadchip cpg datasets demethylase elicit f1 filial h3k4 hd hdac hdac1 hdaci humanmethylation450 huntington implicate infinium k4 lys4 methylated offspring overlapping phenotypes profoundly sperm striatal talk transgenerational	attains cbx3 collaboration compacted copresence e2f6 e2fs entailing h2a hp1gamma integral l3mbtl1 l3mbtl2 marks mblr mbt monoubiquitination necessitated overlap polycomb prc1 prc1l4 rb1 repression repressive ring1 ring2 rnai
Tagcloud (Difference) ?		4b beadchip cpg datasets demethylase elicit f1 filial h3k4 hd hdac hdac1 hdaci humanmethylation450 huntington implicate infinium k4 lys4 methylated offspring overlapping phenotypes profoundly sperm striatal talk transgenerational	attains cbx3 collaboration compacted copresence e2f6 e2fs entailing h2a hp1gamma integral l3mbtl1 l3mbtl2 marks mblr mbt monoubiquitination necessitated overlap polycomb prc1 prc1l4 rb1 repression repressive ring1 ring2 rnai
Tagcloud (Intersection) ?