ARL6IP4 and ARL6

Number of citations of the paper that reports this interaction (PMID 10508919)
7

Data Source:
HPRD (two hybrid)

		ARL6IP4	ARL6
Gene Name		ADP-ribosylation factor-like 6 interacting protein 4	ADP-ribosylation factor-like 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Nuclear Speck	Cytoplasm Cytosol Axonemal Microtubule Plasma Membrane Cilium Axoneme Membrane Membrane Coat BBSome Ciliary Membrane Extracellular Vesicular Exosome Primary Cilium
	Molecular Function	Protein Binding Poly(A) RNA Binding	Protein Binding GTP Binding Phospholipid Binding Metal Ion Binding
	Biological Process	MRNA Processing RNA Splicing	Protein Targeting To Membrane Organelle Organization Small GTPase Mediated Signal Transduction Determination Of Left/right Symmetry Brain Development Visual Perception Regulation Of Smoothened Signaling Pathway Retina Layer Formation Wnt Signaling Pathway Melanosome Transport Cilium Assembly Fat Cell Differentiation Intermembrane Transport Protein Polymerization Protein Localization To Cilium
Pathways			Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS			Male infertility ( 19478329)
Protein-Protein Interactions		11 interactors: ARL6 CSNK2A1 ETS1 FOS IKBKG RBM39 RNF41 SRPK1 SRPK2 SRSF11 THAP1	6 interactors: ARL6IP1 ARL6IP4 ARL6IP5 ARL6IP6 ATL2 SEC61B
Entrez ID		51329	84100
HPRD ID		09640	10588
Ensembl ID		ENSG00000182196	ENSG00000113966
Uniprot IDs		B3V0L0 B3V0L1 Q66PJ3	Q9H0F7
PDB IDs			2H57
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Regulation Of RNA Metabolic Process RNA Splicing Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Heterocycle Metabolic Process Nucleus Organization Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process MRNA Processing Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Viral Genome Replication Regulation Of Myeloid Cell Differentiation Nitrogen Compound Metabolic Process MRNA Metabolic Process RNA Processing Immune Response Negative Regulation Of Viral Genome Replication Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Cellular Macromolecule Biosynthetic Process Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity TRIF-dependent Toll-like Receptor Signaling Pathway Macromolecule Biosynthetic Process Regulation Of MRNA Splicing, Via Spliceosome MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Viral Genome Replication Nuclear Speck Organization MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Viral Process Negative Regulation Of Viral Process Positive Regulation Of Myeloid Cell Differentiation Regulation Of Cell Cycle Toll-like Receptor 4 Signaling Pathway Regulation Of MRNA Processing Regulation Of Metabolic Process Phosphorylation Intracellular Signal Transduction Intermembrane Transport Regulation Of RNA Splicing Cellular Response To Reactive Oxygen Species	Cotranslational Protein Targeting To Membrane Protein Targeting To Membrane Establishment Of Protein Localization To Membrane Negative Regulation Of Mitochondrial Membrane Potential Retrograde Protein Transport, ER To Cytosol
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