ANKRD27 and VAMP7

Number of citations of the paper that reports this interaction (PMID 19745841)
17

Data Source:
BioGRID (pull down, affinity chromatography technology)

		ANKRD27	VAMP7
Gene Name		ankyrin repeat domain 27 (VPS9 domain)	vesicle-associated membrane protein 7
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosome Early Endosome Late Endosome Plasma Membrane Membrane Tubular Endosome	Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Lamellipodium Cell Junction Secretory Granule Transport Vesicle Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Platelet Alpha Granule Pseudopodium SNARE Complex Late Endosome Membrane Azurophil Granule Membrane Neuron Projection Intracellular Membrane-bounded Organelle Apical Part Of Cell Synapse Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Rab GTPase Binding	SNARE Binding SNAP Receptor Activity Protein Binding Syntaxin Binding
	Biological Process	Negative Regulation Of SNARE Complex Assembly Positive Regulation Of GTPase Activity Early Endosome To Late Endosome Transport Retrograde Transport, Endosome To Plasma Membrane	Autophagic Vacuole Fusion Exocytosis ER To Golgi Vesicle-mediated Transport Post-Golgi Vesicle-mediated Transport Endocytosis Vesicle Fusion Phagocytosis, Engulfment Endosome To Lysosome Transport Vesicle-mediated Transport Calcium Ion-dependent Exocytosis Triglyceride Transport SNARE Complex Assembly Golgi To Plasma Membrane Protein Transport Eosinophil Degranulation Neutrophil Degranulation Natural Killer Cell Degranulation Vesicle Fusion With Golgi Apparatus Membrane Organization Regulation Of Protein Targeting To Vacuolar Membrane Positive Regulation Of Histamine Secretion By Mast Cell
Pathways			Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding Lysosome Vesicle Biogenesis
Drugs
Diseases
GWAS		Major depressive disorder ( 23377640)
Protein-Protein Interactions		2 interactors: SMAD1 VAMP7	11 interactors: AGFG1 ANKRD27 AP3D1 DNAJC5 SNAP23 SNAP25 SNAP29 STX1A STX3 STX4 STX7
Entrez ID		84079	6845
HPRD ID		10650	02084
Ensembl ID		ENSG00000105186	ENSG00000124333
Uniprot IDs		Q96NW4	P51809
PDB IDs		4B93	2DMW
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Targeting To Vacuolar Membrane Cellular Protein Complex Assembly Positive Regulation Of Histamine Secretion By Mast Cell Regulation Of Histamine Secretion By Mast Cell Triglyceride Transport Eosinophil Degranulation Primary MiRNA Processing Neutrophil Degranulation Osteoblast Fate Commitment Vesicle Fusion With Golgi Apparatus Cellular Macromolecular Complex Assembly Neutrophil Activation Involved In Immune Response Natural Killer Cell Degranulation SNARE Complex Assembly SMAD Protein Complex Assembly Positive Regulation Of Mast Cell Degranulation Phagocytosis, Engulfment Positive Regulation Of Mast Cell Activation Mesodermal Cell Fate Commitment Membrane Invagination Positive Regulation Of Regulated Secretory Pathway Cardiac Muscle Cell Proliferation Neutrophil Mediated Immunity Production Of MiRNAs Involved In Gene Silencing By MiRNA Neutrophil Activation Cellular Response To BMP Stimulus Golgi To Plasma Membrane Protein Transport Natural Killer Cell Activation Involved In Immune Response Protein Complex Assembly Natural Killer Cell Mediated Cytotoxicity Mesodermal Cell Differentiation Natural Killer Cell Mediated Immunity Regulation Of Mast Cell Degranulation Cell Fate Commitment Involved In Formation Of Primary Germ Layer Cardiac Muscle Tissue Growth Endosome To Lysosome Transport Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Leukocyte Mediated Cytotoxicity Positive Regulation Of Dendrite Morphogenesis Golgi To Plasma Membrane Transport Gene Silencing By MiRNA Regulation Of Mast Cell Activation Cellular Response To DsRNA Defense Response Positive Regulation Of Cartilage Development Regulation Of Regulated Secretory Pathway Posttranscriptional Gene Silencing Leukocyte Degranulation Calcium Ion-dependent Exocytosis	Synaptic Vesicle Fusion To Presynaptic Membrane Vesicle Organization Synaptic Vesicle Transport Vesicle Fusion Synaptic Vesicle Exocytosis Organelle Fusion Establishment Of Vesicle Localization Vesicle Localization Organelle Localization Neurotransmitter Secretion Membrane Fusion Regulation Of Neurotransmitter Levels Establishment Of Organelle Localization Neurotransmitter Transport Establishment Of Localization In Cell Vesicle-mediated Transport Cellular Localization Synaptic Transmission Exocytosis Vesicle Docking Membrane Docking Membrane Organization Secretion By Cell Cell-cell Signaling Secretion Synaptic Vesicle Priming Transport Intracellular Transport Positive Regulation Of Synaptic Transmission Organelle Organization Protein Transport Establishment Of Protein Localization Long-term Synaptic Potentiation Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Surface Protein Localization Synaptic Vesicle Docking Regulation Of Synaptic Transmission Cellular Protein Complex Assembly Regulation Of Protein Localization Intracellular Protein Transport Regulation Of Protein Localization To Cell Surface Regulation Of Synaptic Plasticity Glutamate Secretion Regulation Of Cellular Localization Positive Regulation Of Protein Localization To Plasma Membrane Cellular Component Assembly Regulation Of Cellular Component Organization Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion
Tagcloud ?			acidification alters autophagosome compartments correlative docking fourth hallmark hijacking inside intravesicular lc3 localizes multimembrane nonacidic pave pseudotuberculosis replicate replicates traffic ultrastructurally unexpectedly uninfected vacuoles vamp3 vamps vesicle ycvs yersinia
Tagcloud (Difference) ?			acidification alters autophagosome compartments correlative docking fourth hallmark hijacking inside intravesicular lc3 localizes multimembrane nonacidic pave pseudotuberculosis replicate replicates traffic ultrastructurally unexpectedly uninfected vacuoles vamp3 vamps vesicle ycvs yersinia
Tagcloud (Intersection) ?