ANKRD27 and RAB40B

Number of citations of the paper that reports this interaction (PubMedID 25661869)
48

Data Source:
BioGRID (two hybrid)

		ANKRD27	RAB40B
Description		ankyrin repeat domain 27	RAB40B, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Endosome Early Endosome Late Endosome Cytosol Plasma Membrane Endomembrane System Membrane Transport Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Melanosome Neuron Projection Tubular Endosome	Ruffle Nuclear Envelope Cytoplasm Endosome Cytosol Plasma Membrane Synaptic Vesicle Membrane Lamellipodium Lamellipodium Membrane Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	SNARE Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Positive Regulation Of Neuron Projection Development Protein Transport Endocytic Recycling Negative Regulation Of SNARE Complex Assembly Endosome To Melanosome Transport Early Endosome To Late Endosome Transport Neuron Projection Morphogenesis Positive Regulation Of Dendrite Morphogenesis	Exocytosis Protein Ubiquitination Positive Regulation Of Cell Migration Negative Regulation Of Actin Filament Bundle Assembly Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Lamellipodium Organization Cellular Detoxification
Pathways		RAB GEFs exchange GTP for GDP on RABs	RAB geranylgeranylation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Eosinophilic esophagitis ( 25407941) Gut microbiota relative abundance (Bacteroides) ( 33208821) Major depressive disorder ( 23377640) Red cell distribution width ( 27863252 28957414) Systemic lupus erythematosus ( 33536424)	Colorectal cancer or advanced adenoma ( 30510241)
Interacting Genes		5 interacting genes: RAB40A RAB40B RAB40C SMAD1 VAMP7	10 interacting genes: ANKRD27 APP CRYAA EFEMP2 FHIT FHL3 RAP2A RAP2B RAP2C WFDC1
Entrez ID		84079	10966
HPRD ID		10650	11472
Ensembl ID		ENSG00000105186	ENSG00000141542
Uniprot IDs		Q96NW4	Q12829
PDB IDs		4B93 4CYM 4CZ2 6TL0
Enriched GO Terms of Interacting Partners?		Exocytosis Secretion By Cell Ubiquitin-like Ligase-substrate Adaptor Activity Secretion Synaptic Vesicle Cul5-RING Ubiquitin Ligase Complex Endosome GTPase Activity GTP Binding Vesicle-mediated Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cell-substrate Junction Organization Lipid Droplet Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Protein Ubiquitination Homomeric SMAD Protein Complex Intracellular Signal Transduction Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Cellular Component Organization Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Negative Regulation Of Focal Adhesion Disassembly Post-translational Protein Modification Positive Regulation Of Histamine Secretion By Mast Cell Lamellipodium Anti-Mullerian Hormone Receptor Signaling Pathway Regulation Of Cellular Component Organization SMAD Protein Complex Regulation Of Histamine Secretion By Mast Cell Eosinophil Degranulation Neutrophil Degranulation Natural Killer Cell Degranulation Macromolecule Catabolic Process Heteromeric SMAD Protein Complex DEAD/H-box RNA Helicase Binding Primary MiRNA Binding Proteolysis Co-SMAD Binding Cell Fate Commitment Involved In Formation Of Primary Germ Layer Primary MiRNA Processing Golgi Apparatus Positive Regulation Of Dendrite Development Positive Regulation Of Mast Cell Degranulation I-SMAD Binding Cardiac Conduction System Development Lipid Droplet Formation	Rap Protein Signal Transduction Bounding Membrane Of Organelle Recycling Endosome Cytoplasmic Vesicle Membrane GDP Binding Endomembrane System G Protein Activity Recycling Endosome Membrane Endosome Establishment Of Endothelial Intestinal Barrier Regulation Of Protein Tyrosine Kinase Activity Cell-cell Contact Zone Establishment Of Endothelial Barrier Endothelial Cell Development Amyloid-beta Complex Growth Cone Lamellipodium Synaptic Membrane Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Adenylylsulfatase Activity Adenylylsulfate-ammonia Adenylyltransferase Activity Diadenosine Triphosphate Catabolic Process Regulation Of Dendrite Morphogenesis Small GTPase-mediated Signal Transduction Tertiary Granule Membrane Positive Regulation Of Smooth Muscle Cell-matrix Adhesion GTPase Activity Negative Regulation Of Cell Migration Acetylcholine Receptor Activator Activity Regulation Of Cellular Component Organization Intracellular Signaling Cassette Cell Development Lipoprotein Particle Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of Protein Import GTP Binding Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Negative Regulation Of SNARE Complex Assembly PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Cell Migration Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway
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