ANKRD27 and RAB40C

Number of citations: 48 (PubMedID 25661869)
Data Source: BioGRID (two hybrid)

		ANKRD27	RAB40C
Name		ankyrin repeat domain 27	RAB40C, member RAS oncogene family
Structure			No pdb structure
GO Annotations	Cellular Component	Lysosome Endosome Early Endosome Late Endosome Cytosol Plasma Membrane Endomembrane System Membrane Transport Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Melanosome Neuron Projection Tubular Endosome	Golgi Membrane Cytoplasm Endosome Golgi Apparatus Lipid Droplet Cytosol Plasma Membrane Synaptic Vesicle Membrane Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	SNARE Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Positive Regulation Of Neuron Projection Development Protein Transport Endocytic Recycling Negative Regulation Of SNARE Complex Assembly Endosome To Melanosome Transport Early Endosome To Late Endosome Transport Neuron Projection Morphogenesis Positive Regulation Of Dendrite Morphogenesis	Exocytosis Cell Migration Protein Ubiquitination Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Lipid Droplet Formation
Pathways		RAB GEFs exchange GTP for GDP on RABs	RAB geranylgeranylation
GWAS		Blood protein levels ( 30072576 ) Eosinophilic esophagitis ( 25407941 ) Gut microbiota relative abundance (Bacteroides) ( 33208821 ) Major depressive disorder ( 23377640 ) Red cell distribution width ( 27863252 28957414 ) Systemic lupus erythematosus ( 33536424 )	Adiponectin levels ( 33562295 ) Disc degeneration (lumbar) ( 22993228 ) Height ( 18391950 ) Hip circumference adjusted for BMI ( 34021172 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 )
Interacting Genes		5 interacting genes: RAB40A RAB40B RAB40C SMAD1 VAMP7	3 interacting genes: ANKRD27 PSD TOE1
Entrez ID		84079	57799
HPRD ID		10650	10182
Ensembl ID		ENSG00000105186	ENSG00000197562
Uniprot IDs		Q96NW4	Q96S21
PDB IDs		4B93 4CYM 4CZ2 6TL0	Not available
GO Terms Enriched among Interactors		Exocytosis Secretion By Cell Ubiquitin-like Ligase-substrate Adaptor Activity Secretion Synaptic Vesicle Cul5-RING Ubiquitin Ligase Complex Endosome GTPase Activity GTP Binding Vesicle-mediated Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cell-substrate Junction Organization Lipid Droplet Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Protein Ubiquitination Homomeric SMAD Protein Complex Intracellular Signal Transduction Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Cellular Component Organization Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Negative Regulation Of Focal Adhesion Disassembly Post-translational Protein Modification Positive Regulation Of Histamine Secretion By Mast Cell Lamellipodium Anti-Mullerian Hormone Receptor Signaling Pathway Regulation Of Cellular Component Organization SMAD Protein Complex Regulation Of Histamine Secretion By Mast Cell Eosinophil Degranulation Neutrophil Degranulation Natural Killer Cell Degranulation Macromolecule Catabolic Process Heteromeric SMAD Protein Complex DEAD/H-box RNA Helicase Binding Primary MiRNA Binding Proteolysis Co-SMAD Binding Cell Fate Commitment Involved In Formation Of Primary Germ Layer Primary MiRNA Processing Golgi Apparatus Positive Regulation Of Dendrite Development Positive Regulation Of Mast Cell Degranulation I-SMAD Binding Cardiac Conduction System Development Lipid Droplet Formation	Guanyl-nucleotide Exchange Factor Activity Negative Regulation Of SNARE Complex Assembly Negative Regulation Of Vesicle Fusion Tubular Endosome Endosome To Melanosome Transport SnRNA Binding Poly(A)-specific Ribonuclease Activity Regulation Of SNARE Complex Assembly Postsynaptic Density, Intracellular Component Regulation Of ARF Protein Signal Transduction SnRNA 3'-end Processing Early Endosome To Late Endosome Transport Positive Regulation Of Dendrite Morphogenesis Regulation Of Vesicle Fusion SnRNA Processing 3'-5'-RNA Exonuclease Activity