ANKRD27

Gene Name		ankyrin repeat domain 27 (VPS9 domain)
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Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosome Early Endosome Late Endosome Plasma Membrane Membrane Tubular Endosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Rab GTPase Binding
	Biological Process	Negative Regulation Of SNARE Complex Assembly Positive Regulation Of GTPase Activity Early Endosome To Late Endosome Transport Retrograde Transport, Endosome To Plasma Membrane
Pathways
Drugs
Diseases
GWAS		Major depressive disorder ( 23377640)
Protein-protein Interactions		2 interactors: SMAD1 VAMP7
Entrez ID		84079
HPRD ID		10650
Ensembl ID		ENSG00000105186
Uniprot IDs		Q96NW4
PDB IDs		4B93
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Targeting To Vacuolar Membrane Cellular Protein Complex Assembly Positive Regulation Of Histamine Secretion By Mast Cell Regulation Of Histamine Secretion By Mast Cell Triglyceride Transport Eosinophil Degranulation Primary MiRNA Processing Neutrophil Degranulation Osteoblast Fate Commitment Vesicle Fusion With Golgi Apparatus Cellular Macromolecular Complex Assembly Neutrophil Activation Involved In Immune Response Natural Killer Cell Degranulation SNARE Complex Assembly SMAD Protein Complex Assembly Positive Regulation Of Mast Cell Degranulation Phagocytosis, Engulfment Positive Regulation Of Mast Cell Activation Mesodermal Cell Fate Commitment Membrane Invagination Positive Regulation Of Regulated Secretory Pathway Cardiac Muscle Cell Proliferation Neutrophil Mediated Immunity Production Of MiRNAs Involved In Gene Silencing By MiRNA Neutrophil Activation Cellular Response To BMP Stimulus Golgi To Plasma Membrane Protein Transport Natural Killer Cell Activation Involved In Immune Response Protein Complex Assembly Natural Killer Cell Mediated Cytotoxicity Mesodermal Cell Differentiation Natural Killer Cell Mediated Immunity Regulation Of Mast Cell Degranulation Cell Fate Commitment Involved In Formation Of Primary Germ Layer Cardiac Muscle Tissue Growth Endosome To Lysosome Transport Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Leukocyte Mediated Cytotoxicity Positive Regulation Of Dendrite Morphogenesis Golgi To Plasma Membrane Transport Gene Silencing By MiRNA Regulation Of Mast Cell Activation Cellular Response To DsRNA Defense Response Positive Regulation Of Cartilage Development Regulation Of Regulated Secretory Pathway Posttranscriptional Gene Silencing Leukocyte Degranulation Calcium Ion-dependent Exocytosis
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