GORASP1 and NEFL

Number of citations of the paper that reports this interaction (PubMedID 26871637)
43

Data Source:
BioGRID (two hybrid)

		GORASP1	NEFL
Description		golgi reassembly stacking protein 1	neurofilament light chain
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Cis-Golgi Network Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Cytoplasm Cytosol Cytoskeleton Intermediate Filament Neurofilament Axon Growth Cone Neuromuscular Junction Cell Projection Neuron Projection Intermediate Filament Cytoskeleton Schaffer Collateral - CA1 Synapse Cholinergic Synapse Postsynaptic Intermediate Filament Cytoskeleton Presynaptic Intermediate Filament Cytoskeleton Axon Cytoplasm
	Molecular Function	Protein Binding Metal Ion Binding	Structural Constituent Of Cytoskeleton Protein Binding Tubulin Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Phospholipase Binding Protein-containing Complex Binding Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
	Biological Process	Protein N-linked Glycosylation Golgi Organization Protein Transport Negative Regulation Of Dendrite Morphogenesis Establishment Of Protein Localization To Plasma Membrane Golgi Ribbon Formation	Microtubule Cytoskeleton Organization Axonogenesis Anterograde Axonal Transport Retrograde Axonal Transport Response To Toxic Substance Peripheral Nervous System Axon Regeneration Axonal Transport Of Mitochondrion Spinal Cord Development Hippocampus Development Cerebral Cortex Development Regulation Of Axon Diameter Neurofilament Bundle Assembly Locomotion Response To Peptide Hormone Intermediate Filament Polymerization Or Depolymerization Intermediate Filament Organization Intermediate Filament Bundle Assembly Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Neuromuscular Process Controlling Balance Protein Polymerization Response To Corticosterone Neurofilament Cytoskeleton Organization Regulation Of Synapse Maturation Motor Neuron Apoptotic Process Postsynaptic Modulation Of Chemical Synaptic Transmission Postsynaptic Intermediate Filament Cytoskeleton Organization Response To Sodium Arsenite Response To Acrylamide Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Social communication problems ( 24564958)	Fear of minor pain ( 28701861) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)
Interacting Genes		17 interacting genes: AGPS CASP3 CASP7 CDK1 GOLGA2 HIPK3 LONRF1 MAPK6 NEFL PLK1 PRKD2 RPS6KA1 SCRN1 TGFA TMED2 TMED3 TRAF4	55 interacting genes: BRD7 CCDC13 CCDC172 CCDC33 CCNC CDK5RAP2 CEP57L1 CHD3 DES DSCAM ENKD1 FXR1 GFAP GOLGA2 GORASP1 GRIN1 HGS ITSN1 KDM1A KIFC3 KLC3 KRT13 KRT15 KRT18 MAP2 MTMR2 MTUS2 MYO15B MYO5A NDN NEFH NEIL3 NEK6 NME7 PDE4DIP PIAS4 PKN1 PPP1R16B PPP1R18 PRMT6 RBM11 SHANK3 SKIL SMYD1 SPTAN1 TERF1 TEX11 TRIM55 TRIM63 TSC1 TXLNB USHBP1 USP2 VIM YWHAG
Entrez ID		64689	4747
HPRD ID		06038	01206
Ensembl ID		ENSG00000114745	ENSG00000277586
Uniprot IDs		A0A8Q3SHU6 A0A8Q3WL08 B3KPY8 B4E1H8 Q9BQQ3	P07196
PDB IDs		4REY 6G8T 6G8W
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Golgi Organization Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Regulation Of Synaptic Vesicle Cycle Protein Kinase Activity Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Kinase Activity Protein Modification Process Cellular Response To Staurosporine COPII-coated ER To Golgi Transport Vesicle Regulation Of Apoptotic Process Golgi Disassembly Regulation Of Programmed Cell Death Centrosome Cycle Hepatocyte Proliferation G2/M Transition Of Mitotic Cell Cycle Protein Metabolic Process Cell Cycle G2/M Phase Transition Potassium Channel Inhibitor Activity Golgi Cisterna Membrane Fibroblast Apoptotic Process Mitotic Nuclear Membrane Disassembly Transferase Activity Intracellular Signal Transduction Nuclear Membrane Disassembly Microtubule Organizing Center Organization Membrane Disassembly COPI-coated Vesicle Membrane Protein Kinase Binding Cytoplasm Protein Poly-ADP-ribosylation Aspartic-type Endopeptidase Activity Neuron Apoptotic Process Peptidyl-threonine Phosphorylation Execution Phase Of Apoptosis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Localization To Site Of Double-strand Break Microtubule Cytoskeleton Organization Involved In Mitosis Apoptotic Process Programmed Cell Death Cell Death Mitotic Cell Cycle Phase Transition Mitotic G2 DNA Damage Checkpoint Signaling Phosphate-containing Compound Metabolic Process Cellular Response To Alkaloid ATP Binding Chromosome Condensation Cell Cycle Phase Transition	Cytoskeleton Microtubule Microtubule Binding Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Cytoplasm Intermediate Filament Organization Organelle Organization Centrosome Structural Constituent Of Cytoskeleton Intermediate Filament Cell Projection Microtubule-based Process Regulation Of Nervous System Development Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Neuron Projection Centrosome Cycle Intermediate Filament Cytoskeleton Regulation Of Neurogenesis Supramolecular Fiber Organization Regulation Of Developmental Process Regulation Of Microtubule Polymerization Regulation Of Neuron Projection Development Negative Regulation Of Cellular Component Organization Positive Regulation Of Neurogenesis Plasma Membrane Bounded Cell Projection Organization Scaffold Protein Binding Dendritic Spine Cell Projection Organization Microtubule Organizing Center Organization Gamma-tubulin Binding Protein Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Nervous System Development Regulation Of Cell Development Regulation Of Cell Projection Organization Microtubule Organizing Center Regulation Of Cell Differentiation Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Organelle Organization Regulation Of Organelle Transport Along Microtubule Kinesin Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Protein-containing Complex Assembly Organelle Assembly Calmodulin Binding
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