LRMDA and RABIF

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		LRMDA	RABIF
Name		leucine rich melanocyte differentiation associated	RAB interacting factor
Structure		No pdb structure
GO Annotations	Cellular Component	None	Cytosol Membrane
	Molecular Function	None	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Cell Differentiation Melanocyte Differentiation	Post-Golgi Vesicle-mediated Transport Small GTPase-mediated Signal Transduction Protein Transport Membrane Fusion
GWAS		Appendicular lean mass ( 33097823 ) Atrial fibrillation ( 33990960 ) Chronic obstructive pulmonary disease ( 30804561 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) Microalbuminuria ( 31511532 ) Type 2 diabetes ( 32499647 ) Urinary albumin excretion (no hypertensive medication) ( 30220432 ) Urinary albumin-to-creatinine ratio ( 31511532 )	No GWAS studies recorded
Interacting Genes		4 interacting genes: AP1M1 EXOSC5 RAB32 RABIF	27 interacting genes: EIF3F ITGA2 ITGA3 ITGA5 ITGA6 KIFC3 KYAT3 LAMTOR5 LARP1B LMCD1 LNX1 LRMDA LZTS1 RAB10 RAB15 RAB19 RAB1B RAB3A RAB3C RAB3D RAB8A RASSF5 REL TCF4 TERF2IP UTP14A ZNF544
Entrez ID		83938	5877
HPRD ID		12560	04566
Ensembl ID		ENSG00000148655	ENSG00000183155
Uniprot IDs		A0A087WWI0 Q9H2I8	P47224 Q53EV1
PDB IDs		Not available	1FWQ 2FU5
GO Terms Enriched among Interactors		Endosome To Melanosome Transport Melanosome Assembly Melanosome Organization Pigment Granule Organization BLOC-2 Complex Binding AP-3 Adaptor Complex Binding Vesicle-mediated Transport Protein Transport Early Endosome Lumen AP-1 Adaptor Complex Binding Establishment Of Protein Localization Vesicle Organization Clathrin Adaptor Complex Early Endosome AP-1 Adaptor Complex AP-2 Adaptor Complex Binding Phagosome Maturation Exoribonuclease Complex Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance DNA Deamination Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Intracellular Protein Localization RRNA Catabolic Process Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process Clathrin Adaptor Activity Melanosome Membrane GTP-dependent Protein Binding SnRNA 3'-end Processing Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Platelet Dense Granule Organization Intracellular Protein Transport DNA Modification 3'-5'-RNA Exonuclease Activity SnRNA Processing Clathrin-coated Vesicle Membrane Nuclear RNA Surveillance RNA Surveillance Cytosol Organelle Assembly Organelle Membrane SnRNA Metabolic Process Cytoplasmic Vesicle Euchromatin Secretory Granule Organization	Myosin V Binding GTPase Activity GTP Binding Integrin Complex Exocytosis GTP-dependent Protein Binding Integrin-mediated Signaling Pathway Cell-matrix Adhesion Cell-substrate Junction Assembly Secretion By Cell Cell-substrate Junction Organization Cell Junction Organization Synaptic Vesicle Positive Regulation Of Regulated Secretory Pathway Perinuclear Region Of Cytoplasm Secretory Vesicle Cell-cell Adhesion Cell-substrate Adhesion Secretion Skin Morphogenesis Cellular Component Maintenance Protein Transport G Protein Activity Intracellular Protein Localization Regulation Of Exocytosis Mesodermal Cell Differentiation Positive Regulation Of Exocytosis Laminin Binding Focal Adhesion Hydrolase Activity Establishment Of Protein Localization Signaling Receptor Activity Golgi Organization Cell Adhesion Mediated By Integrin Nucleotide Binding Response To Muscle Activity Regulation Of Regulated Secretory Pathway Metal Ion Binding Integrin Alpha6-beta4 Complex Regulation Of Vesicle-mediated Transport Regulation Of Presynaptic Dense Core Granule Exocytosis Evoked Neurotransmitter Secretion Viral Process Integrin Binding Vesicle-mediated Transport Axonogenesis Cell Adhesion Integrin Alpha6-beta1 Complex Positive Regulation Of Epithelial Cell Migration Integrin Alpha3-beta1 Complex