CASP5 and PPHLN1

Number of citations of the paper that reports this interaction (PMID 12853457)
5

Data Source:
HPRD (in vitro)

		CASP5	PPHLN1
Gene Name		caspase 5, apoptosis-related cysteine peptidase	periphilin 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Neuron Projection Neuronal Cell Body IPAF Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex	Nucleoplasm Cytoplasm Golgi Apparatus Intracellular Membrane-bounded Organelle
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Peptidase Activity Scaffold Protein Binding	Poly(A) RNA Binding
	Biological Process	Proteolysis Apoptotic Process Substantia Nigra Development Ectopic Germ Cell Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Pyroptosis Cellular Response To Mechanical Stimulus Execution Phase Of Apoptosis	Keratinization
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: MAX NLRP1 PPHLN1	20 interactors: APP BCL2L1 BRCA1 CASP5 CCDC57 CDC37 CDK6 MTUS2 NAGK PAXIP1 PPL SEPT8 SNCAIP SQSTM1 TGM2 TOMM20 TP53BP2 TSGA10 UFD1L VIM
Entrez ID		838	51535
HPRD ID		04048	10488
Ensembl ID		ENSG00000137757	ENSG00000134283
Uniprot IDs		P51878	B7Z8L1 E9PAX8 F8W6A0 Q8NEY8
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuron Apoptotic Process Neuron Death Response To Peptide	Response To Ionizing Radiation Apoptotic Process Programmed Cell Death Cell Death Death Response To Radiation Positive Regulation Of Histone H3-K4 Methylation Regulation Of Cell Cycle Positive Regulation Of Histone Acetylation Signal Transduction By P53 Class Mediator Developmental Process Regulation Of Histone H3-K4 Methylation Response To Abiotic Stimulus Positive Regulation Of Peptidyl-lysine Acetylation Apoptotic Signaling Pathway Organ Development Positive Regulation Of Protein Acetylation Astrocyte Development Multicellular Organismal Development Anatomical Structure Development System Development Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cell Cycle Positive Regulation Of Histone Methylation Intrinsic Apoptotic Signaling Pathway Intracellular Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Astrocyte Differentiation Regulation Of Histone Acetylation Central Nervous System Development Positive Regulation Of Gene Expression Regulation Of Histone Methylation Neuron Apoptotic Process Positive Regulation Of Histone H4-K20 Methylation Cell Dedifferentiation Positive Regulation Of Histone H3-K36 Methylation Positive Regulation Of Histone H4-K16 Acetylation Apoptotic Process In Bone Marrow Regulation Of Signaling Neuron Death Positive Regulation Of Histone Modification Execution Phase Of Apoptosis Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Synaptic Growth At Neuromuscular Junction Positive Regulation Of Histone H3-K9 Acetylation N-acetylmannosamine Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Cell Differentiation Cellular Protein Metabolic Process Signal Transduction In Response To DNA Damage
Tagcloud ?		11q 18q21 18q22 3p aplp1 carcinoids casp1 casp4 chromosomes clustered dad1 gains gpr112 hierarchical il12a ileal mir133a or51e1 paid prkca profiling q21 q22 q23 ret runx1 rybp spock1 vmat1
Tagcloud (Difference) ?		11q 18q21 18q22 3p aplp1 carcinoids casp1 casp4 chromosomes clustered dad1 gains gpr112 hierarchical il12a ileal mir133a or51e1 paid prkca profiling q21 q22 q23 ret runx1 rybp spock1 vmat1
Tagcloud (Intersection) ?