CASP5 and NLRP1

Number of citations of the paper that reports this interaction (PMID 12191486)
502

Data Source:
HPRD (in vitro, in vivo)

		CASP5	NLRP1
Gene Name		caspase 5, apoptosis-related cysteine peptidase	NLR family, pyrin domain containing 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Neuron Projection Neuronal Cell Body IPAF Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex	Intracellular Nucleus Cytosol NLRP1 Inflammasome Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Peptidase Activity Scaffold Protein Binding	Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Enzyme Binding Protein Domain Specific Binding
	Biological Process	Proteolysis Apoptotic Process Substantia Nigra Development Ectopic Germ Cell Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Pyroptosis Cellular Response To Mechanical Stimulus Execution Phase Of Apoptosis	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Muramyl Dipeptide Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Defense Response To Bacterium Innate Immune Response Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Neuron Apoptotic Process
Pathways			Inflammasomes The NLRP1 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: MAX NLRP1 PPHLN1	9 interactors: APAF1 BCL2 BCL2L1 CASP1 CASP2 CASP5 CASP9 NOD1 PYCARD
Entrez ID		838	22861
HPRD ID		04048	07364
Ensembl ID		ENSG00000137757	ENSG00000091592
Uniprot IDs		P51878	E9PE50 Q9C000 Q9H5Z7
PDB IDs			1PN5 3KAT 4IFP
Enriched GO Terms of Interacting Partners?		Neuron Apoptotic Process Neuron Death Response To Peptide	Apoptotic Process Programmed Cell Death Cell Death Death Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Protein Processing Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Apoptotic Signaling Pathway Response To Biotic Stimulus Positive Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Response To External Stimulus Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Proteolysis Positive Regulation Of Interleukin-1 Secretion Regulation Of Proteolysis Positive Regulation Of Signal Transduction Regulation Of Autophagy Response To Other Organism Regulation Of Interleukin-1 Beta Secretion Innate Immune Response Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Regulation Of Mitochondrial Membrane Potential Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intracellular Signal Transduction Regulation Of Interleukin-1 Beta Production Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Neuron Apoptotic Process Pyroptosis Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Metabolic Process
Tagcloud ?		11q 18q21 18q22 3p aplp1 carcinoids casp1 casp4 chromosomes clustered dad1 gains gpr112 hierarchical il12a ileal mir133a or51e1 paid prkca profiling q21 q22 q23 ret runx1 rybp spock1 vmat1	ancient archaea autoproteolysis autoproteolytic card8 deteriorated extend fam171 fiind gpcr gpcrs gps hfs hlt lrr nacht nucleoporin98 nup98 occluden origination polycystic precedes pyd searches subdomain unc5c upa zonula zu5
Tagcloud (Difference) ?		11q 18q21 18q22 3p aplp1 carcinoids casp1 casp4 chromosomes clustered dad1 gains gpr112 hierarchical il12a ileal mir133a or51e1 paid prkca profiling q21 q22 q23 ret runx1 rybp spock1 vmat1	ancient archaea autoproteolysis autoproteolytic card8 deteriorated extend fam171 fiind gpcr gpcrs gps hfs hlt lrr nacht nucleoporin98 nup98 occluden origination polycystic precedes pyd searches subdomain unc5c upa zonula zu5
Tagcloud (Intersection) ?