GUCD1 and FCHO1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GUCD1	FCHO1
Description		guanylyl cyclase domain containing 1	FCH and mu domain containing endocytic adaptor 1
Image		No pdb structure
GO Annotations	Cellular Component		Nucleoplasm Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin-coated Vesicle Postsynaptic Endocytic Zone
	Molecular Function	Protein Binding	Protein Binding AP-2 Adaptor Complex Binding
	Biological Process	Response To CAMP Liver Regeneration	Endocytosis Clathrin Coat Assembly T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Clathrin-dependent Endocytosis
Pathways			Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)	Basophil count ( 32888494) Coronary artery disease ( 29212778) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Monocyte percentage of white cells ( 32888494) Myocardial infarction ( 33532862)
Interacting Genes		77 interacting genes: ADAM12 ADAMTSL4 APP ATP23 BEGAIN CPSF7 CRX CTAG1A CTAG1B CTH CYSRT1 DRC12 FCHO1 FHL3 FUCA2 HESX1 HOXA1 HSPB7 ID3 ISCA2 KATNBL1 KPRP KRT40 KRTAP1-1 KRTAP1-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP13-3 KRTAP19-5 KRTAP19-6 KRTAP3-2 KRTAP3-3 KRTAP4-2 KRTAP5-6 KRTAP5-7 KRTAP9-2 KRTAP9-8 LASP1 LCE1C LCE2A LCE2B LCE2D LHX3 LNX1 MAP2K5 MEOX2 MORN3 MORN4 NDUFAF6 NGLY1 PCBD2 PCSK5 PFDN5 PSMA1 PTH1R RSPO4 RUNX3 SLC25A48 SMCP SPRY1 SYNGAP1 TCF4 TEPSIN TFAP2D TOLLIP TRIM42 TSPAN4 TXN2 VASN YPEL3 ZBTB42 ZCCHC13 ZNF250 ZNF655 ZNF705D ZNF835	51 interacting genes: ACVR1 APP BYSL CCDC13 CFTR CSNK2A1 CWF19L2 DAB2 DDX6 DNAJC5 ELOA EPS15L1 EXOSC5 FBXL7 GRB7 GUCD1 ITSN1 KAT5 KPRP KRTAP10-1 KRTAP10-5 KRTAP13-2 KRTAP13-4 KRTAP15-1 KRTAP4-12 KRTAP6-1 KRTAP6-3 LGALS14 MAB21L3 NCK1 PCGF1 PHETA1 PHLDA2 PICALM PLAC8 PLSCR4 PRPF3 PRPH PTK6 SH2D4A SMURF1 SRPK2 SYTL4 TCEA2 TCEANC TGFB1 TRIM42 TSPAN4 ZBTB16 ZBTB24 ZNF688
Entrez ID		83606	23149
HPRD ID		12796	16887
Ensembl ID		ENSG00000138867	ENSG00000130475
Uniprot IDs		A0A087WVD9 B4DL90 E7EX77 E9PGZ7 Q7Z629 Q96NT3	A0A0C3SFZ9 A0A8V8TMX9 A0A8V8TNC3 A0A8V8TPM7 B7ZAZ3 M0QYA9 O14526
PDB IDs			7OHI
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Protein Binding Epidermis Development	Intermediate Filament Clathrin-coated Pit Protein Targeting To Vacuole Involved In Autophagy Endosome To Plasma Membrane Transport Vesicle Regulation Of SMAD Protein Signal Transduction Low-density Lipoprotein Particle Receptor Binding Cytosol Positive Regulation Of Aggrephagy Negative Regulation Of Protein Localization To Plasma Membrane Regulation Of Enamel Mineralization Clathrin Coat Of Coated Pit Keratin Filament Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Vesicle-mediated Transport Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Binding Regulation Of Growth Receptor Metabolic Process SMAD Binding Negative Regulation Of Protein Localization Protein Targeting To Vacuole Negative Regulation Of Growth
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