GUCD1 and CTH

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		GUCD1	CTH
Gene Name		guanylyl cyclase domain containing 1	cystathionine gamma-lyase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function		Cystathionine Gamma-lyase Activity Protein Binding Calmodulin Binding Carbon-sulfur Lyase Activity Pyridoxal Phosphate Binding L-cystine L-cysteine-lyase (deaminating) Homocysteine Desulfhydrase Activity L-cysteine Desulfhydrase Activity
	Biological Process		Sulfur Amino Acid Metabolic Process Sulfur Amino Acid Catabolic Process Cysteine Metabolic Process Protein-pyridoxal-5-phosphate Linkage Via Peptidyl-N6-pyridoxal Phosphate-L-lysine Cysteine Biosynthetic Process Transsulfuration Endoplasmic Reticulum Unfolded Protein Response Cellular Nitrogen Compound Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Small Molecule Metabolic Process Protein Sulfhydration Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homotetramerization Hydrogen Sulfide Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway
Pathways			Degradation of cysteine and homocysteine Sulfur amino acid metabolism Cysteine formation from homocysteine Metabolism of amino acids and derivatives
Drugs			Pyridoxal Phosphate L-Cysteine 2-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Imino]-5-Phosphono-Pent-3-Enoic Acid Carboxymethylthio-3-(3-Chlorophenyl)-1,2,4-Oxadiazol L-2-amino-3-butynoic acid
Diseases
GWAS
Protein-Protein Interactions		7 interactors: APP CRX CTH KRT40 KRTAP10-7 NGLY1 TCF4	4 interactors: GUCD1 RECK SDCBP2 WDYHV1
Entrez ID		83606	1491
HPRD ID		12796	09633
Ensembl ID		ENSG00000138867	ENSG00000116761
Uniprot IDs		Q96NT3	P32929
PDB IDs			2NMP 3COG 3ELP
Enriched GO Terms of Interacting Partners?		Regulation Of Neuron Differentiation Protein Sulfhydration Protein-pyridoxal-5-phosphate Linkage Via Peptidyl-N6-pyridoxal Phosphate-L-lysine Positive Regulation Of Photoreceptor Cell Differentiation Regulation Of Neurogenesis Regulation Of Protein Binding Synaptic Growth At Neuromuscular Junction Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Protein-pyridoxal-5-phosphate Linkage Transsulfuration Catenin Import Into Nucleus Regulation Of Cell Development Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Collateral Sprouting In Absence Of Injury Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Maintenance Of DNA Repeat Elements Cysteine Biosynthetic Process Collateral Sprouting Axon Midline Choice Point Recognition Hydrogen Sulfide Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Axon Choice Point Recognition Embryonic Genitalia Morphogenesis Regulation Of Developmental Growth Myoblast Fate Commitment Positive Regulation Of Transcription, DNA-templated Cysteine Metabolic Process Positive Regulation Of Neuron Differentiation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Homocysteine Metabolic Process Neuron Remodeling Secretory Granule Localization Hindgut Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Glycoprotein Catabolic Process Insulin Metabolic Process Generation Of Neurons Regulation Of Cell Differentiation Hindgut Development Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Neurogenesis Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Glycoprotein Biosynthetic Process Neurogenesis
Tagcloud ?		allowed cdna characterize cluster cyclase developmentally downregulated e3 examining guanylyl hepatocellular hybrid identifying library ligase liver livers means modulation nedd4 neural partners proliferative regenerating regeneration studying transcripts ubiquitous whose	additionally allows cbs contribution cystathionase cystathionine cysteine determination employed evaluating gamma glutathione gsh gssg h2s homogenates homoserine hplc inhibiting ketobutyrate measure propargylglycine reactions redox reflect rp synthase totally undertaken
Tagcloud (Difference) ?		allowed cdna characterize cluster cyclase developmentally downregulated e3 examining guanylyl hepatocellular hybrid identifying library ligase liver livers means modulation nedd4 neural partners proliferative regenerating regeneration studying transcripts ubiquitous whose	additionally allows cbs contribution cystathionase cystathionine cysteine determination employed evaluating gamma glutathione gsh gssg h2s homogenates homoserine hplc inhibiting ketobutyrate measure propargylglycine reactions redox reflect rp synthase totally undertaken
Tagcloud (Intersection) ?