GUCD1 and CTH

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		GUCD1	CTH
Description		guanylyl cyclase domain containing 1	cystathionine gamma-lyase
Image		No pdb structure
GO Annotations	Cellular Component		Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding	Cystathionine Gamma-lyase Activity Protein Binding Calmodulin Binding Lyase Activity Pyridoxal Phosphate Binding Identical Protein Binding L-cystine L-cysteine-lyase (deaminating) Homocysteine Desulfhydrase Activity L-cysteine Desulfhydrase Activity Selenocystathionine Gamma-lyase Activity
	Biological Process	Response To CAMP Liver Regeneration	Cysteine Metabolic Process Lipid Metabolic Process Amino Acid Biosynthetic Process Protein-pyridoxal-5-phosphate Linkage Via Peptidyl-N6-pyridoxal Phosphate-L-lysine Cysteine Biosynthetic Process Via Cystathionine Cysteine Biosynthetic Process Transsulfuration Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Sulfhydration Protein Homotetramerization Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Apoptotic Signaling Pathway
Pathways			Degradation of cysteine and homocysteine Cysteine formation from homocysteine Metabolism of ingested SeMet, Sec, MeSec into H2Se
Drugs			Pyridoxal phosphate Cysteine 2-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Imino]-5-Phosphono-Pent-3-Enoic Acid Carboxymethylthio-3-(3-Chlorophenyl)-1,2,4-Oxadiazol L-2-amino-3-butynoic acid
Diseases			Cystathioninuria
GWAS		Acne (severe) ( 24927181) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)	Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Brain volume in infants (grey matter) ( 28763065) Declining hemoglobin trajectory in blood donors ( 33491795) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Seasonality and depression ( 30217971)
Interacting Genes		77 interacting genes: ADAM12 ADAMTSL4 APP ATP23 BEGAIN CPSF7 CRX CTAG1A CTAG1B CTH CYSRT1 DRC12 FCHO1 FHL3 FUCA2 HESX1 HOXA1 HSPB7 ID3 ISCA2 KATNBL1 KPRP KRT40 KRTAP1-1 KRTAP1-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP13-3 KRTAP19-5 KRTAP19-6 KRTAP3-2 KRTAP3-3 KRTAP4-2 KRTAP5-6 KRTAP5-7 KRTAP9-2 KRTAP9-8 LASP1 LCE1C LCE2A LCE2B LCE2D LHX3 LNX1 MAP2K5 MEOX2 MORN3 MORN4 NDUFAF6 NGLY1 PCBD2 PCSK5 PFDN5 PSMA1 PTH1R RSPO4 RUNX3 SLC25A48 SMCP SPRY1 SYNGAP1 TCF4 TEPSIN TFAP2D TOLLIP TRIM42 TSPAN4 TXN2 VASN YPEL3 ZBTB42 ZCCHC13 ZNF250 ZNF655 ZNF705D ZNF835	4 interacting genes: GUCD1 NTAQ1 RECK SDCBP2
Entrez ID		83606	1491
HPRD ID		12796	09633
Ensembl ID		ENSG00000138867	ENSG00000116761
Uniprot IDs		A0A087WVD9 B4DL90 E7EX77 E9PGZ7 Q7Z629 Q96NT3	P32929
PDB IDs			2NMP 3COG 3ELP 5EIG 5TSU 5TT2 6NBA 6OVG
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Protein Binding Epidermis Development	Prostaglandin F Receptor Activity Protein-N-terminal Glutamine Amidohydrolase Activity Protein-N-terminal Asparagine Amidohydrolase Activity Regulation Of Establishment Of Blood-brain Barrier
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