GUCD1 and NGLY1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		GUCD1	NGLY1
Gene Name		guanylyl cyclase domain containing 1	N-glycanase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Cytoplasm
	Molecular Function		Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Metal Ion Binding
	Biological Process		Glycoprotein Catabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: APP CRX CTH KRT40 KRTAP10-7 NGLY1 TCF4	12 interactors: APP FAF1 GUCD1 NSFL1C RAD23A RAD23B SRPK2 TRAFD1 TRIM54 UBQLN1 UBXN2B VCP
Entrez ID		83606	55768
HPRD ID		12796	10118
Ensembl ID		ENSG00000138867	ENSG00000151092
Uniprot IDs		Q96NT3	Q96IV0
PDB IDs			2CCQ 2CM0
Enriched GO Terms of Interacting Partners?		Regulation Of Neuron Differentiation Protein Sulfhydration Protein-pyridoxal-5-phosphate Linkage Via Peptidyl-N6-pyridoxal Phosphate-L-lysine Positive Regulation Of Photoreceptor Cell Differentiation Regulation Of Neurogenesis Regulation Of Protein Binding Synaptic Growth At Neuromuscular Junction Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Protein-pyridoxal-5-phosphate Linkage Transsulfuration Catenin Import Into Nucleus Regulation Of Cell Development Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Collateral Sprouting In Absence Of Injury Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Maintenance Of DNA Repeat Elements Cysteine Biosynthetic Process Collateral Sprouting Axon Midline Choice Point Recognition Hydrogen Sulfide Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Axon Choice Point Recognition Embryonic Genitalia Morphogenesis Regulation Of Developmental Growth Myoblast Fate Commitment Positive Regulation Of Transcription, DNA-templated Cysteine Metabolic Process Positive Regulation Of Neuron Differentiation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Homocysteine Metabolic Process Neuron Remodeling Secretory Granule Localization Hindgut Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Glycoprotein Catabolic Process Insulin Metabolic Process Generation Of Neurons Regulation Of Cell Differentiation Hindgut Development Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Neurogenesis Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Glycoprotein Biosynthetic Process Neurogenesis	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Nuclear Envelope Reassembly Regulation Of Protein Catabolic Process Nucleus Organization Response To Stress Cellular Response To Stress Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Proteolysis Autophagic Vacuole Assembly Response To Stimulus Regulation Of Protein Metabolic Process Cellular Response To Stimulus Macroautophagy Nuclear Envelope Organization Regulation Of Viral Genome Replication Nuclear Speck Organization Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Viral Process Golgi Organization Protein Metabolic Process Nucleotide-excision Repair Regulation Of Metabolic Process Synaptic Growth At Neuromuscular Junction Nucleotide-excision Repair, DNA Damage Recognition Cellular Component Assembly Vacuole Organization Collateral Sprouting In Absence Of Injury Membrane Fusion Cellular Response To Starvation Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death DNA Repair Collateral Sprouting Axon Midline Choice Point Recognition Retrograde Protein Transport, ER To Cytosol
Tagcloud ?		allowed cdna characterize cluster cyclase developmentally downregulated e3 examining guanylyl hepatocellular hybrid identifying library ligase liver livers means modulation nedd4 neural partners proliferative regenerating regeneration studying transcripts ubiquitous whose	ablation acetylglucosaminidase catalyzed consequences cytosolic deglycosylating deglycosylation dysregulation emerging endo engase erad fibroblast generating glcnac glycanase glycoprotein herein knockout mammals mef misfolded phenotypic pngase precise prone restored unconventional underscores
Tagcloud (Difference) ?		allowed cdna characterize cluster cyclase developmentally downregulated e3 examining guanylyl hepatocellular hybrid identifying library ligase liver livers means modulation nedd4 neural partners proliferative regenerating regeneration studying transcripts ubiquitous whose	ablation acetylglucosaminidase catalyzed consequences cytosolic deglycosylating deglycosylation dysregulation emerging endo engase erad fibroblast generating glcnac glycanase glycoprotein herein knockout mammals mef misfolded phenotypic pngase precise prone restored unconventional underscores
Tagcloud (Intersection) ?