GUCD1 and ISCA2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GUCD1	ISCA2
Description		guanylyl cyclase domain containing 1	iron-sulfur cluster assembly 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Mitochondrion Mitochondrial Matrix Mitochondrial [4Fe-4S] Assembly Complex
	Molecular Function	Protein Binding	Iron Ion Binding Protein Binding Identical Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Response To CAMP Liver Regeneration	Iron-sulfur Cluster Assembly Protein Maturation
Pathways			Mitochondrial iron-sulfur cluster biogenesis Maturation of TCA enzymes and regulation of TCA cycle
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)	Soluble receptor for advanced glycation end-product levels ( 26915486)
Interacting Genes		77 interacting genes: ADAM12 ADAMTSL4 APP ATP23 BEGAIN CPSF7 CRX CTAG1A CTAG1B CTH CYSRT1 DRC12 FCHO1 FHL3 FUCA2 HESX1 HOXA1 HSPB7 ID3 ISCA2 KATNBL1 KPRP KRT40 KRTAP1-1 KRTAP1-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP13-3 KRTAP19-5 KRTAP19-6 KRTAP3-2 KRTAP3-3 KRTAP4-2 KRTAP5-6 KRTAP5-7 KRTAP9-2 KRTAP9-8 LASP1 LCE1C LCE2A LCE2B LCE2D LHX3 LNX1 MAP2K5 MEOX2 MORN3 MORN4 NDUFAF6 NGLY1 PCBD2 PCSK5 PFDN5 PSMA1 PTH1R RSPO4 RUNX3 SLC25A48 SMCP SPRY1 SYNGAP1 TCF4 TEPSIN TFAP2D TOLLIP TRIM42 TSPAN4 TXN2 VASN YPEL3 ZBTB42 ZCCHC13 ZNF250 ZNF655 ZNF705D ZNF835	8 interacting genes: AKT1 ANKS1A EIF3E FAM124B GEM GUCD1 NTAQ1 SUOX
Entrez ID		83606	122961
HPRD ID		12796	17090
Ensembl ID		ENSG00000138867	ENSG00000165898
Uniprot IDs		A0A087WVD9 B4DL90 E7EX77 E9PGZ7 Q7Z629 Q96NT3	Q86U28
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Protein Binding Epidermis Development
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