GUCD1 and HESX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GUCD1	HESX1
Description		guanylyl cyclase domain containing 1	HESX homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component		Chromatin Nucleus
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Response To CAMP Liver Regeneration	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Brain Development Gonad Development Gene Expression Wnt Signaling Pathway Stem Cell Population Maintenance Pituitary Gland Development Thyroid Gland Development Forebrain Development Otic Vesicle Formation Multicellular Organism Growth Camera-type Eye Development Nose Development Negative Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Forebrain Morphogenesis Leukemia Inhibitory Factor Signaling Pathway Stem Cell Differentiation Canonical Wnt Signaling Pathway ERK1 And ERK2 Cascade Cellular Response To Cadmium Ion
Pathways
Drugs
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD) Septo-optic dysplasia
GWAS		Acne (severe) ( 24927181) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Family history of Alzheimer's disease ( 30617256)
Interacting Genes		77 interacting genes: ADAM12 ADAMTSL4 APP ATP23 BEGAIN CPSF7 CRX CTAG1A CTAG1B CTH CYSRT1 DRC12 FCHO1 FHL3 FUCA2 HESX1 HOXA1 HSPB7 ID3 ISCA2 KATNBL1 KPRP KRT40 KRTAP1-1 KRTAP1-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP13-3 KRTAP19-5 KRTAP19-6 KRTAP3-2 KRTAP3-3 KRTAP4-2 KRTAP5-6 KRTAP5-7 KRTAP9-2 KRTAP9-8 LASP1 LCE1C LCE2A LCE2B LCE2D LHX3 LNX1 MAP2K5 MEOX2 MORN3 MORN4 NDUFAF6 NGLY1 PCBD2 PCSK5 PFDN5 PSMA1 PTH1R RSPO4 RUNX3 SLC25A48 SMCP SPRY1 SYNGAP1 TCF4 TEPSIN TFAP2D TOLLIP TRIM42 TSPAN4 TXN2 VASN YPEL3 ZBTB42 ZCCHC13 ZNF250 ZNF655 ZNF705D ZNF835	12 interacting genes: AIRIM CATIP GUCD1 HOXC8 KDM1A NCOR1 NPAS2 PRMT6 PROP1 STAT3 TLE1 UBL5
Entrez ID		83606	8820
HPRD ID		12796	03482
Ensembl ID		ENSG00000138867	ENSG00000163666
Uniprot IDs		A0A087WVD9 B4DL90 E7EX77 E9PGZ7 Q7Z629 Q96NT3	Q9UBX0
PDB IDs			2K40
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Protein Binding Epidermis Development	Transcription Regulator Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of Glycolytic Process Nucleus Negative Regulation Of ATP Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Regulation Of Androgen Receptor Signaling Pathway Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Regulation Of RNA Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Corepressor Activity Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Glycolytic Process Histone H2AR3 Methyltransferase Activity Regulation Of Carbohydrate Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Behavior Hypophysis Morphogenesis Regulation Of ATP Metabolic Process Regulation Of MiRNA Transcription Negative Regulation Of Intracellular Signal Transduction Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Response To CAMP Regulation Of MiRNA Metabolic Process Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Negative Regulation Of Catabolic Process Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Histone Arginine N-methyltransferase Activity Negative Regulation Of Canonical NF-kappaB Signal Transduction Somatotropin Secreting Cell Differentiation RNA Sequestering Activity Protein Demethylase Activity
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