MXD3 and SMC3

Number of citations of the paper that reports this interaction (PMID 9528857)
4

Data Source:
BioGRID (two hybrid, pull down)

		MXD3	SMC3
Gene Name		MAX dimerization protein 3	structural maintenance of chromosomes 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Chromosome, Centromeric Region Chromatin Lateral Element Spindle Pole Basement Membrane Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Cohesin Complex Cohesin Core Heterodimer Nuclear Matrix Meiotic Cohesin Complex Nuclear Meiotic Cohesin Complex
	Molecular Function	DNA Binding Protein Dimerization Activity	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Dynein Binding Protein Heterodimerization Activity
	Biological Process	Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair Mitotic Spindle Organization Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Mitotic Nuclear Division Meiotic Nuclear Division Signal Transduction Stem Cell Maintenance Negative Regulation Of DNA Endoreduplication Cell Division
Pathways			Establishment of Sister Chromatid Cohesion Mitotic Prometaphase Mitotic Telophase/Cytokinesis Separation of Sister Chromatids Meiotic synapsis Cohesin Loading onto Chromatin Mitotic Anaphase S Phase M Phase Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: KRTAP10-7 MAGEA11 MAX NOTCH2NL SIN3A SMC3	14 interactors: APC CEP63 DISC1 FEZ1 FEZ2 KIFAP3 MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B TRAF3IP1
Entrez ID		83463	9126
HPRD ID		14791	05829
Ensembl ID		ENSG00000213347	ENSG00000108055
Uniprot IDs		B4E0J1 Q9BW11	Q9UQE7
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Methylglyoxal Negative Regulation Of Histone H3-K27 Acetylation Positive Regulation Of Chromatin Silencing Negative Regulation Of DNA Endoreduplication Cellular Response To Stress Regulation Of DNA Endoreduplication Mitotic Sister Chromatid Cohesion Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Regulation Of Cell Cycle Process Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Defense Response To Virus By Host Developmental Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Histone Acetylation Regulation Of Gene Silencing Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Protein Acetylation Regulation Of Transcription Regulatory Region DNA Binding Response To Wounding Sister Chromatid Cohesion Regulation Of Defense Response To Virus By Host Cellular Response To Stimulus Response To Organonitrogen Compound Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Mitotic Spindle Organization Transcription From RNA Polymerase II Promoter Negative Regulation Of DNA Binding Negative Regulation Of DNA Replication Regulation Of Histone Acetylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Phase Transition Cellular Response To Glucose Stimulus Neuron Apoptotic Process Chromosome Organization Cell Differentiation Response To Stress Histone Deacetylation Neuron Death DNA Metabolic Process Response To Axon Injury Protein Deacetylation Cellular Glucose Homeostasis	Microtubule-based Process Movement Of Cell Or Subcellular Component Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Cellular Metabolic Process Cell Projection Morphogenesis Cell Part Morphogenesis Microtubule Cytoskeleton Organization Sister Chromatid Cohesion Organelle Organization Intraciliary Transport Cell Morphogenesis Cell Cycle Checkpoint Cell Projection Organization Negative Regulation Of Cell Proliferation Positive Regulation Of Calcium-dependent Cell-cell Adhesion Cell Cycle Mitotic Nuclear Division Negative Regulation Of Biosynthetic Process Microtubule-based Movement Regulation Of Cell Proliferation Nervous System Development Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Signal Transduction In Response To DNA Damage Canonical Wnt Signaling Pathway Generation Of Neurons Eye Development Cellular Localization Cell Division Neuron Development Neurogenesis Negative Regulation Of Odontogenesis Organelle Assembly Cell Cycle Process Spindle Organization Regulation Of Cell Projection Organization Cell Development Negative Regulation Of DNA Endoreduplication Negative Regulation Of Transcription, DNA-templated Axonogenesis Negative Regulation Of Nucleic Acid-templated Transcription Cytoskeleton Organization Neuron Differentiation Cellular Component Assembly Negative Regulation Of RNA Biosynthetic Process Plus-end-directed Vesicle Transport Along Microtubule Stem Cell Maintenance Positive Regulation Of Wnt Signaling Pathway Metaphase/anaphase Transition Of Mitotic Cell Cycle Axon Development
Tagcloud ?		apoptotic change daoy donors enriched g0 g1 g2 healthy hematopoietic highly knock leukemia line lymphoblastic marrow medulloblastoma mobilized mononuclear numbers peripheral plays populations possibly preb precursor reh resulted stem	12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc1a undetected
Tagcloud (Difference) ?		apoptotic change daoy donors enriched g0 g1 g2 healthy hematopoietic highly knock leukemia line lymphoblastic marrow medulloblastoma mobilized mononuclear numbers peripheral plays populations possibly preb precursor reh resulted stem	12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc1a undetected
Tagcloud (Intersection) ?