SF3B5 and U2AF2

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (pull down, biochemical)

		SF3B5	U2AF2
Description		splicing factor 3b subunit 5	U2 small nuclear RNA auxiliary factor 2
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GO Annotations	Cellular Component	SAGA Complex Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome	Commitment Complex Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Prespliceosome U2AF Complex
	Molecular Function	RNA Binding Protein Binding Splicing Factor Binding	Nucleic Acid Binding RNA Binding Protein Binding Poly-pyrimidine Tract Binding Enzyme Binding Pre-mRNA 3'-splice Site Binding C2H2 Zinc Finger Domain Binding Molecular Function Inhibitor Activity
	Biological Process	MRNA Splicing, Via Spliceosome Regulation Of DNA Repair MRNA Processing RNA Splicing Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription U2-type Prespliceosome Assembly	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Negative Regulation Of Protein Ubiquitination Positive Regulation Of RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Protein hydroxylation
Drugs
Diseases
GWAS			HDL cholesterol levels ( 32203549) Menopause (age at onset) ( 26414677)
Interacting Genes		6 interacting genes: MIR21 MIRLET7G STAMBPL1 TRAPPC6A U2AF2 UBC	71 interacting genes: - APBB1 ATXN1 BEND7 CCAR1 CDC42 CHIC2 CPSF7 DACH1 DDX6 DPPA2 DVL2 EPB41 FUBP1 GEMIN2 GLIS2 HLA-DMA HMBOX1 IL7R INO80B KHDC4 KHDRBS3 LURAP1 MAP1B MRPL15 NKAPD1 OGT OTUB2 PHF5A PIN1 POLR2A PRPF40A PUF60 QKI RBFOX2 RBM11 RBM39 RBM4 RBMY1F RBMY1J SAP30BP SCAF11 SF1 SF3B3 SF3B5 SF3B6 SMAD5 SNRPA SRPK1 SRPK2 SRSF1 SRSF11 SRSF3 STAC3 SUGP1 SUMO2 TCERG1 TCF23 THAP1 TLE5 TOP1 U2AF1 USP7 WT1 ZNF107 ZNF526 ZNF57 ZNF71 ZNF835 ZRSR2 ZRSR2P1
Entrez ID		83443	11338
HPRD ID		18042	01872
Ensembl ID		ENSG00000169976	ENSG00000063244
Uniprot IDs		Q9BWJ5	P26368
PDB IDs		5IFE 5O9Z 5Z56 5Z57 5Z58 5ZYA 6AH0 6EN4 6FF4 6FF7 6QX9 6Y50 6Y5Q 7ABG 7ABH 7ABI 7B0I 7B91 7B92 7B9C 7DVQ 7EVN 7EVO 7KTS 7OMF 7ONB 7OPI 7Q3L 7Q4O 7Q4P 7QTT 7VPX 8CH6 8H6E 8H6J 8H6K 8H6L 8H7G 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y7E	1JMT 1O0P 1OPI 1U2F 2G4B 2HZC 2M0G 2U2F 2YH0 2YH1 3VAF 3VAG 3VAH 3VAI 3VAJ 3VAK 3VAL 3VAM 4FXW 4TU7 4TU8 4TU9 5EV1 5EV2 5EV3 5EV4 5W0G 5W0H 6TR0 6XLV 6XLW 6XLX 7S3A 7S3B 7S3C 7SN6 8P25 9C7A 9C7B 9DWU
Enriched GO Terms of Interacting Partners?		Poly-pyrimidine Tract Binding Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity RISC Complex Positive Regulation Of Myofibroblast Differentiation Negative Regulation Of Interleukin-21 Production Phenotypic Switching Cellular Response To Resveratrol Negative Regulation Of Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Vascular Associated Smooth Muscle Contraction Negative Regulation Of Arginine Catabolic Process Negative Regulation Of Endothelial Tube Morphogenesis Positive Regulation Of Inflammatory Response To Wounding Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Positive Regulation Of Replicative Senescence Negative Regulation Of Aortic Smooth Muscle Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Cellular Response To Hypoxia Response To Resveratrol Commitment Complex Negative Regulation Of Intracellular Signal Transduction Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Regulation Of Arginine Metabolic Process Negative Regulation Of Chondrocyte Proliferation U2AF Complex Pre-mRNA 3'-splice Site Binding Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Rac Protein Signal Transduction Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Cell-cell Adhesion Cellular Response To Oxygen-containing Compound Retinal Cell Apoptotic Process Regulation Of Glutamine Family Amino Acid Metabolic Process Regulation Of Endothelial Tube Morphogenesis Negative Regulation Of Interleukin-1-mediated Signaling Pathway Regulation Of Myofibroblast Differentiation Cellular Response To L-leucine Metal-dependent Deubiquitinase Activity TRAPPIII Protein Complex Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Defense Response Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Interleukin-1-mediated Signaling Pathway	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing RNA Binding RNA Metabolic Process Nucleic Acid Binding Nucleoplasm Regulation Of RNA Splicing Nucleic Acid Metabolic Process Nucleus Spliceosomal Complex Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nuclear Speck Regulation Of Nucleobase-containing Compound Metabolic Process Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Binding Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process U2AF Complex Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Binding Positive Regulation Of Biosynthetic Process RS Domain Binding Pre-mRNA 3'-splice Site Binding Protein-containing Complex Assembly U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex MRNA Splice Site Recognition Negative Regulation Of RNA Metabolic Process Protein-containing Complex Organization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Splicing
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