SF3B5 and MIRLET7G

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		SF3B5	MIRLET7G
Description		splicing factor 3b subunit 5	microRNA let-7g
Image			No pdb structure
GO Annotations	Cellular Component	SAGA Complex Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome	Extracellular Space RISC Complex
	Molecular Function	RNA Binding Protein Binding Splicing Factor Binding	MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	MRNA Splicing, Via Spliceosome Regulation Of DNA Repair MRNA Processing RNA Splicing Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription U2-type Prespliceosome Assembly	Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Negative Regulation Of SMAD Protein Signal Transduction Cellular Response To Glucose Stimulus Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 23974872)
Interacting Genes		6 interacting genes: MIR21 MIRLET7G STAMBPL1 TRAPPC6A U2AF2 UBC	116 interacting genes: ADARB1 APOBEC3B AQR ATXN2L C1QBP CCAR1 CDC40 CDC5L CELF1 CHERP CPSF1 CRTAP CSTF3 DARS1 DDX1 DDX21 DDX23 DDX3X DDX3Y DHX36 DHX37 EIF2AK2 EPRS1 ESRP1 FAM98A FAM98B FIP1L1 FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PAXBP1 PDCD11 PLOD1 PLRG1 PTBP1 PTCD3 PUF60 PUM1 PUM2 PURA PURB QARS1 RARS1 RBFOX2 RBM10 RBM12B RBM14 RBM17 RBM4 RBM4B RBM5 RBM6 RBMS1 RTCA RTCB SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SF3B5 SFPQ SPOUT1 STRBP SUGP1 SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TUT4 TUT7 U2SURP UPF1 UTP20 XAB2 YBX1 YBX2 YBX3 ZFR
Entrez ID		83443	406890
HPRD ID		18042
Ensembl ID		ENSG00000169976	ENSG00000199150
Uniprot IDs		Q9BWJ5
PDB IDs		5IFE 5O9Z 5Z56 5Z57 5Z58 5ZYA 6AH0 6EN4 6FF4 6FF7 6QX9 6Y50 6Y5Q 7ABG 7ABH 7ABI 7B0I 7B91 7B92 7B9C 7DVQ 7EVN 7EVO 7KTS 7OMF 7ONB 7OPI 7Q3L 7Q4O 7Q4P 7QTT 7VPX 8CH6 8H6E 8H6J 8H6K 8H6L 8H7G 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y7E
Enriched GO Terms of Interacting Partners?		Poly-pyrimidine Tract Binding Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity RISC Complex Positive Regulation Of Myofibroblast Differentiation Negative Regulation Of Interleukin-21 Production Phenotypic Switching Cellular Response To Resveratrol Negative Regulation Of Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Vascular Associated Smooth Muscle Contraction Negative Regulation Of Arginine Catabolic Process Negative Regulation Of Endothelial Tube Morphogenesis Positive Regulation Of Inflammatory Response To Wounding Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Positive Regulation Of Replicative Senescence Negative Regulation Of Aortic Smooth Muscle Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Cellular Response To Hypoxia Response To Resveratrol Commitment Complex Negative Regulation Of Intracellular Signal Transduction Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Regulation Of Arginine Metabolic Process Negative Regulation Of Chondrocyte Proliferation U2AF Complex Pre-mRNA 3'-splice Site Binding Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Rac Protein Signal Transduction Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Cell-cell Adhesion Cellular Response To Oxygen-containing Compound Retinal Cell Apoptotic Process Regulation Of Glutamine Family Amino Acid Metabolic Process Regulation Of Endothelial Tube Morphogenesis Negative Regulation Of Interleukin-1-mediated Signaling Pathway Regulation Of Myofibroblast Differentiation Cellular Response To L-leucine Metal-dependent Deubiquitinase Activity TRAPPIII Protein Complex Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Defense Response Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Interleukin-1-mediated Signaling Pathway	RNA Binding RNA Processing Nucleic Acid Binding RNA Metabolic Process MRNA Processing MRNA Metabolic Process RNA Splicing Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex Macromolecule Metabolic Process Regulation Of RNA Splicing Nucleoplasm Regulation Of MRNA Metabolic Process Nucleus Catalytic Step 2 Spliceosome Post-transcriptional Regulation Of Gene Expression Ribonucleoprotein Complex MiRNA Binding Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Cytoplasmic Stress Granule Regulation Of Translation MRNA 3'-UTR Binding Aminoacyl-tRNA Synthetase Multienzyme Complex Regulation Of RNA Stability Regulation Of Gene Expression Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Spliceosomal Complex Assembly Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Catabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of MRNA Catabolic Process U2 SnRNP RNA Stabilization MRNA Stabilization Negative Regulation Of Translation Regulation Of Metabolic Process MiRNA Processing Protein-RNA Complex Assembly TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity U2-type Prespliceosome Assembly Negative Regulation Of Macromolecule Metabolic Process
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