SF3B5 and MIR21

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		SF3B5	MIR21
Description		splicing factor 3b subunit 5	microRNA 21
Image			No pdb structure
GO Annotations	Cellular Component	SAGA Complex Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome	Extracellular Space Cytoplasm RISC Complex Extracellular Exosome Extracellular Vesicle
	Molecular Function	RNA Binding Protein Binding Splicing Factor Binding	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	MRNA Splicing, Via Spliceosome Regulation Of DNA Repair MRNA Processing RNA Splicing Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription U2-type Prespliceosome Assembly	Blood Vessel Development Positive Regulation Of Cytokine Production Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cytokine-mediated Signaling Pathway Embryo Implantation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Keratinocyte Proliferation Negative Regulation Of Angiogenesis Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Projection Organization Negative Regulation Of Type I Interferon Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-21 Production Collagen Metabolic Process Negative Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Rac Protein Signal Transduction Negative Regulation Of Rho Protein Signal Transduction MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Phenotypic Switching Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of MAPK Cascade Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Innate Immune Response Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Inflammatory Response Negative Regulation Of Stress Fiber Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Type I Interferon-mediated Signaling Pathway Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Negative Regulation Of Cartilage Development Endothelial Tube Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To Virus Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cellular Response To Hypoxia Negative Regulation Of Arginine Catabolic Process Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Negative Regulation Of Chondrocyte Proliferation Regulation Of Extracellular Matrix Organization Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Potassium Ion Export Across Plasma Membrane Cellular Response To Resveratrol Positive Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Replicative Senescence Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Myofibroblast Differentiation Negative Regulation Of Hydrogen Sulfide Biosynthetic Process Negative Regulation Of Aortic Smooth Muscle Cell Differentiation Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Endothelial Tube Morphogenesis Retinal Cell Apoptotic Process Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Differentiation Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases
GWAS			Monocyte count ( 29403010)
Interacting Genes		6 interacting genes: MIR21 MIRLET7G STAMBPL1 TRAPPC6A U2AF2 UBC	95 interacting genes: AIMP2 APOBEC3B ATXN2L C1QBP CELF1 CELF2 CPSF1 CSTF3 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUFIP2 PATL1 PDCD11 PGAM5 PTBP1 PTBP3 PTCD3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM10 RBM14 RBM17 RBM4 RBM4B RTCA RTCB SF3B1 SF3B2 SF3B3 SF3B4 SF3B5 SFPQ SPOUT1 SUGP2 SYMPK SYNCRIP TAF15 TENT2 TRA2A TRA2B TRIM25 U2SURP UPF1 USP36 UTP20 YBX1 YBX2 YBX3 ZFR ZNF106
Entrez ID		83443	406991
HPRD ID		18042
Ensembl ID		ENSG00000169976	ENSG00000284190
Uniprot IDs		Q9BWJ5
PDB IDs		5IFE 5O9Z 5Z56 5Z57 5Z58 5ZYA 6AH0 6EN4 6FF4 6FF7 6QX9 6Y50 6Y5Q 7ABG 7ABH 7ABI 7B0I 7B91 7B92 7B9C 7DVQ 7EVN 7EVO 7KTS 7OMF 7ONB 7OPI 7Q3L 7Q4O 7Q4P 7QTT 7VPX 8CH6 8H6E 8H6J 8H6K 8H6L 8H7G 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y7E
Enriched GO Terms of Interacting Partners?		Poly-pyrimidine Tract Binding Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity RISC Complex Positive Regulation Of Myofibroblast Differentiation Negative Regulation Of Interleukin-21 Production Phenotypic Switching Cellular Response To Resveratrol Negative Regulation Of Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Vascular Associated Smooth Muscle Contraction Negative Regulation Of Arginine Catabolic Process Negative Regulation Of Endothelial Tube Morphogenesis Positive Regulation Of Inflammatory Response To Wounding Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Positive Regulation Of Replicative Senescence Negative Regulation Of Aortic Smooth Muscle Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Cellular Response To Hypoxia Response To Resveratrol Commitment Complex Negative Regulation Of Intracellular Signal Transduction Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Regulation Of Arginine Metabolic Process Negative Regulation Of Chondrocyte Proliferation U2AF Complex Pre-mRNA 3'-splice Site Binding Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Rac Protein Signal Transduction Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Cell-cell Adhesion Cellular Response To Oxygen-containing Compound Retinal Cell Apoptotic Process Regulation Of Glutamine Family Amino Acid Metabolic Process Regulation Of Endothelial Tube Morphogenesis Negative Regulation Of Interleukin-1-mediated Signaling Pathway Regulation Of Myofibroblast Differentiation Cellular Response To L-leucine Metal-dependent Deubiquitinase Activity TRAPPIII Protein Complex Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Defense Response Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Interleukin-1-mediated Signaling Pathway	RNA Binding Nucleic Acid Binding RNA Metabolic Process RNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process MRNA Processing RNA Splicing Nucleobase-containing Compound Metabolic Process Regulation Of RNA Splicing MRNA Binding Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Nucleus MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleoplasm Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Processing Ribonucleoprotein Complex Regulation Of MRNA Splicing, Via Spliceosome Cytoplasmic Stress Granule Aminoacyl-tRNA Synthetase Multienzyme Complex Spliceosomal Complex Regulation Of Translation Negative Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Negative Regulation Of RNA Catabolic Process MiRNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Catalytic Step 2 Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process MRNA Stabilization Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Metabolic Process Negative Regulation Of Translation TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation Ligase Activity P-body Nucleolus Positive Regulation Of Gene Expression Pre-mRNA Binding
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