GSDMD

Name	gasdermin D
Structure
Interactors	9 interactors: ASPG CASP1 KCTD6 MEOX2 MFHAS1 PSMA1 ZBTB33 ZNF426 ZNF558
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Mitochondrial Membrane Specific Granule Lumen Canonical Inflammasome Complex NLRP3 Inflammasome Complex Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Wide Pore Channel Activity Phosphatidylinositol-4-phosphate Binding Phosphatidic Acid Binding Cardiolipin Binding
	Biological Process	Plasma Membrane Repair Immune System Process Inflammatory Response Protein Secretion Programmed Cell Death Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-18 Production Interleukin-18-mediated Signaling Pathway Defense Response To Bacterium NLRP3 Inflammasome Complex Assembly Innate Immune Response Ceramide Biosynthetic Process Pore Complex Assembly Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Protein Homooligomerization Protein Maturation Transmembrane Transport Pyroptotic Inflammatory Response Interleukin-1-mediated Signaling Pathway Pyroptotic Cell Death
Pathways	Release of apoptotic factors from the mitochondria Interleukin-1 processing Pyroptosis Regulation of TLR by endogenous ligand Neutrophil degranulation Purinergic signaling in leishmaniasis infection CASP4-mediated substrate cleavage CASP5-mediated substrate cleavage
GWAS	Alanine aminotransferase levels ( 33547301 ) Monocyte count ( 32888494 ) Schizophrenia ( 31268507 )
Entrez ID	79792
HPRD ID	11014
Ensembl ID	ENSG00000104518
Uniprot IDs	P57764
PDB IDs	5NH1 5WQT 6AO4 6KN0 6N9O 6VFE 7Z1X