WNT5A and ROR2

Number of citations of the paper that reports this interaction (PMID 12839624)
112

Data Source:
HPRD (in vitro)

		WNT5A	ROR2
Gene Name		wingless-type MMTV integration site family, member 5A	receptor tyrosine kinase-like orphan receptor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Clathrin-coated Endocytic Vesicle Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Frizzled Binding Frizzled-2 Binding Receptor Tyrosine Kinase-like Orphan Receptor Binding Cytokine Activity Protein Domain Specific Binding Transcription Regulatory Region DNA Binding Receptor Agonist Activity	Transmembrane Receptor Protein Tyrosine Kinase Activity Frizzled Binding Protein Binding ATP Binding Wnt-protein Binding
	Biological Process	Activation Of MAPK Activity Ameboidal-type Cell Migration Establishment Of Planar Polarity Somitogenesis Epithelial To Mesenchymal Transition Neural Tube Closure Positive Regulation Of Endothelial Cell Proliferation Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Positive Regulation Of Cytokine Secretion Involved In Immune Response Type B Pancreatic Cell Development Optic Cup Formation Involved In Camera-type Eye Development Protein Phosphorylation Wnt Signaling Pathway, Calcium Modulating Pathway Activation Of JUN Kinase Activity Axon Guidance Hindgut Morphogenesis Midgut Development Male Gonad Development Anterior/posterior Axis Specification, Embryo Response To Organic Substance Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Olfactory Bulb Interneuron Development Neuron Differentiation Keratinocyte Differentiation Lung Development Negative Regulation Of BMP Signaling Pathway Positive Regulation Of CGMP Metabolic Process Activation Of Protein Kinase B Activity Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Protein Localization Post-anal Tail Morphogenesis Non-canonical Wnt Signaling Pathway Via JNK Cascade Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Wound Healing Embryonic Digit Morphogenesis Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of Chemokine Biosynthetic Process Cell Fate Commitment Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Ossification Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Embryonic Skeletal System Development Genitalia Development Negative Regulation Of Axon Extension Involved In Axon Guidance Hypophysis Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Inflammatory Response Negative Chemotaxis Positive Regulation Of NF-kappaB Transcription Factor Activity Cartilage Development Negative Regulation Of Synapse Assembly Palate Development Convergent Extension Involved In Organogenesis Uterus Development Cervix Development Vagina Development Canonical Wnt Signaling Pathway Urinary Bladder Development Face Development Positive Regulation Of Type I Interferon-mediated Signaling Pathway Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Mesenchymal-epithelial Cell Signaling Negative Regulation Of Prostatic Bud Formation Mammary Gland Branching Involved In Thelarche Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Response To Cytokine Stimulus Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Cartilage Development Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis Positive Regulation Of Thymocyte Apoptotic Process Cellular Response To Lipopolysaccharide Cellular Response To Calcium Ion Cellular Response To Retinoic Acid Cellular Response To Interferon-gamma Hematopoietic Stem Cell Proliferation Dopaminergic Neuron Differentiation Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Mesenchymal Cell Proliferation Primitive Streak Formation Positive Regulation Of Protein Kinase C Signaling Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Interleukin-8 Secretion	Cartilage Condensation Somitogenesis Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway JNK Cascade Multicellular Organismal Development Negative Regulation Of Cell Proliferation Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Embryonic Genitalia Morphogenesis Inner Ear Morphogenesis Positive Regulation Of Transcription, DNA-templated Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes WNT ligand biogenesis and trafficking beta-catenin independent WNT signaling WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Ca2+ pathway TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins WNT5A-dependent internalization of FZD4 XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)	WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS			Bipolar disorder and schizophrenia ( 22688191)
Protein-Protein Interactions		3 interactors: FZD1 FZD5 ROR2	13 interactors: C1orf94 CRX DAB1 DAZAP2 FZD2 FZD5 IKBKG MAGED1 MAP3K7 PRR20A RBPMS WNT5A ZMYM4
Entrez ID		7474	4920
HPRD ID		01293	03822
Ensembl ID		ENSG00000114251	ENSG00000169071
Uniprot IDs		B3KQX9 P41221	Q01974
PDB IDs			3ZZW 4GT4
Enriched GO Terms of Interacting Partners?		Non-canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Wnt Signaling Pathway Canonical Wnt Signaling Pathway Segmentation Epithelium Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Organ Morphogenesis Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Wnt Signaling Pathway Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Canonical Wnt Signaling Pathway Involved In Osteoblast Differentiation Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Autocrine Signaling Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Anterior/posterior Pattern Specification Regulation Of Chorionic Trophoblast Cell Proliferation Wnt Signaling Pathway, Calcium Modulating Pathway Spemann Organizer Formation Tissue Development Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Muscular Septum Morphogenesis Embryonic Genitalia Morphogenesis Chorionic Trophoblast Cell Differentiation Chorion Development Membranous Septum Morphogenesis Anatomical Structure Morphogenesis Pattern Specification Process Hard Palate Development Regulation Of Tight Junction Assembly Embryonic Organ Development Reproductive Structure Development Positive Regulation Of Cellular Metabolic Process Post-embryonic Camera-type Eye Development Branching Involved In Labyrinthine Layer Morphogenesis Negative Regulation Of Catenin Import Into Nucleus Reproductive System Development Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Signal Transduction Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Sensory Organ Development Organ Development Embryonic Morphogenesis	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Non-canonical Wnt Signaling Pathway Regulation Of Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of MAPK Cascade Regulation Of Signaling Positive Regulation Of JUN Kinase Activity Regulation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Regulation Of Protein Metabolic Process JNK Cascade Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytokine Production Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Planar Cell Polarity Pathway Involved In Neural Tube Closure Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Activation Of MAPK Activity Regulation Of Intracellular Signal Transduction Anterior/posterior Axis Specification, Embryo
Tagcloud ?		abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt4 wnt6 wnt7a wnt9a	alkaline alpi apical apicobasal applying border brush cathode coordinating created cue cytoskeleton determines electric electrical enterocytes erk1 ezrin faces lkb1 lumen mimic orienting polarity polarized polarizing remodeled stk11 transepithelial
Tagcloud (Difference) ?		abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt4 wnt6 wnt7a wnt9a	alkaline alpi apical apicobasal applying border brush cathode coordinating created cue cytoskeleton determines electric electrical enterocytes erk1 ezrin faces lkb1 lumen mimic orienting polarity polarized polarizing remodeled stk11 transepithelial
Tagcloud (Intersection) ?