WNT5A and FZD5

Number of citations of the paper that reports this interaction (PMID 9054360)
86

Data Source:
HPRD (in vivo)

		WNT5A	FZD5
Gene Name		wingless-type MMTV integration site family, member 5A	frizzled class receptor 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Clathrin-coated Endocytic Vesicle Membrane Extracellular Vesicular Exosome	Golgi Membrane Plasma Membrane Tight Junction Cell Surface Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Frizzled Binding Frizzled-2 Binding Receptor Tyrosine Kinase-like Orphan Receptor Binding Cytokine Activity Protein Domain Specific Binding Transcription Regulatory Region DNA Binding Receptor Agonist Activity	G-protein Coupled Receptor Activity Protein Binding Wnt-protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity
	Biological Process	Activation Of MAPK Activity Ameboidal-type Cell Migration Establishment Of Planar Polarity Somitogenesis Epithelial To Mesenchymal Transition Neural Tube Closure Positive Regulation Of Endothelial Cell Proliferation Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Positive Regulation Of Cytokine Secretion Involved In Immune Response Type B Pancreatic Cell Development Optic Cup Formation Involved In Camera-type Eye Development Protein Phosphorylation Wnt Signaling Pathway, Calcium Modulating Pathway Activation Of JUN Kinase Activity Axon Guidance Hindgut Morphogenesis Midgut Development Male Gonad Development Anterior/posterior Axis Specification, Embryo Response To Organic Substance Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Olfactory Bulb Interneuron Development Neuron Differentiation Keratinocyte Differentiation Lung Development Negative Regulation Of BMP Signaling Pathway Positive Regulation Of CGMP Metabolic Process Activation Of Protein Kinase B Activity Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Protein Localization Post-anal Tail Morphogenesis Non-canonical Wnt Signaling Pathway Via JNK Cascade Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Wound Healing Embryonic Digit Morphogenesis Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of Chemokine Biosynthetic Process Cell Fate Commitment Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Ossification Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Embryonic Skeletal System Development Genitalia Development Negative Regulation Of Axon Extension Involved In Axon Guidance Hypophysis Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Inflammatory Response Negative Chemotaxis Positive Regulation Of NF-kappaB Transcription Factor Activity Cartilage Development Negative Regulation Of Synapse Assembly Palate Development Convergent Extension Involved In Organogenesis Uterus Development Cervix Development Vagina Development Canonical Wnt Signaling Pathway Urinary Bladder Development Face Development Positive Regulation Of Type I Interferon-mediated Signaling Pathway Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Mesenchymal-epithelial Cell Signaling Negative Regulation Of Prostatic Bud Formation Mammary Gland Branching Involved In Thelarche Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Response To Cytokine Stimulus Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Cartilage Development Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis Positive Regulation Of Thymocyte Apoptotic Process Cellular Response To Lipopolysaccharide Cellular Response To Calcium Ion Cellular Response To Retinoic Acid Cellular Response To Interferon-gamma Hematopoietic Stem Cell Proliferation Dopaminergic Neuron Differentiation Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Mesenchymal Cell Proliferation Primitive Streak Formation Positive Regulation Of Protein Kinase C Signaling Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Interleukin-8 Secretion	Embryonic Axis Specification Angiogenesis G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Anterior/posterior Axis Specification, Embryo Neuron Differentiation Embryonic Camera-type Eye Development Post-embryonic Camera-type Eye Development Positive Regulation Of Interferon-gamma Production T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Spemann Organizer Formation Canonical Wnt Signaling Pathway Apoptotic Process Involved In Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Labyrinthine Layer Blood Vessel Development Chorionic Trophoblast Cell Differentiation Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Chorionic Trophoblast Cell Proliferation Regulation Of Tight Junction Assembly
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes WNT ligand biogenesis and trafficking beta-catenin independent WNT signaling WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Ca2+ pathway TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins WNT5A-dependent internalization of FZD4 XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Ca2+ pathway TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: FZD1 FZD5 ROR2	11 interactors: ABI3BP GOPC GSK3B LRP6 LZTFL1 RGS2 ROR2 RPS6KA6 UBTD1 WNT5A WNT7A
Entrez ID		7474	7855
HPRD ID		01293	03427
Ensembl ID		ENSG00000114251	ENSG00000163251
Uniprot IDs		B3KQX9 P41221	Q13467
PDB IDs
Enriched GO Terms of Interacting Partners?		Non-canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Wnt Signaling Pathway Canonical Wnt Signaling Pathway Segmentation Epithelium Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Organ Morphogenesis Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Wnt Signaling Pathway Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Canonical Wnt Signaling Pathway Involved In Osteoblast Differentiation Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Autocrine Signaling Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Anterior/posterior Pattern Specification Regulation Of Chorionic Trophoblast Cell Proliferation Wnt Signaling Pathway, Calcium Modulating Pathway Spemann Organizer Formation Tissue Development Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Muscular Septum Morphogenesis Embryonic Genitalia Morphogenesis Chorionic Trophoblast Cell Differentiation Chorion Development Membranous Septum Morphogenesis Anatomical Structure Morphogenesis Pattern Specification Process Hard Palate Development Regulation Of Tight Junction Assembly Embryonic Organ Development Reproductive Structure Development Positive Regulation Of Cellular Metabolic Process Post-embryonic Camera-type Eye Development Branching Involved In Labyrinthine Layer Morphogenesis Negative Regulation Of Catenin Import Into Nucleus Reproductive System Development Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Signal Transduction Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Sensory Organ Development Organ Development Embryonic Morphogenesis	Regulation Of Canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Embryonic Development Non-canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Negative Regulation Of Wnt Signaling Pathway Cartilage Development Pericardium Morphogenesis Epithelial To Mesenchymal Transition Genitalia Development Negative Regulation Of Signal Transduction Morphogenesis Of An Epithelial Sheet Connective Tissue Development Stem Cell Development Negative Regulation Of Signaling Regulation Of MAPK Cascade Single Organism Reproductive Process Embryonic Digit Morphogenesis Sex Differentiation Regulation Of Phosphorylation Somitogenesis Reproductive Process Developmental Process Involved In Reproduction Stem Cell Differentiation Embryonic Pattern Specification Cell Differentiation Negative Regulation Of Cardiac Muscle Hypertrophy Somite Development Primitive Streak Formation Negative Regulation Of Muscle Hypertrophy Regulation Of Phosphorus Metabolic Process Palate Development Regulation Of Embryonic Development Axis Specification Segmentation Mesenchymal Cell Development Negative Regulation Of Phosphorylation Convergent Extension Positive Regulation Of Peptidyl-threonine Phosphorylation Uterus Development Mesenchymal Cell Differentiation Negative Regulation Of Protein Serine/threonine Kinase Activity Dopaminergic Neuron Differentiation Forebrain Development Central Nervous System Development
Tagcloud ?		abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt4 wnt6 wnt7a wnt9a	aberrant aberrantly accessible bcor cd127 contributors covering cxcl14 fzd8 granulocyte hes6 hic1 hypermethylated hypomorphic island itpka leukemic megakaryocyte prdm16 preleukemic progenitors pu publicly robo3 runx1 sca shortage tal1 underscoring
Tagcloud (Difference) ?		abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt4 wnt6 wnt7a wnt9a	aberrant aberrantly accessible bcor cd127 contributors covering cxcl14 fzd8 granulocyte hes6 hic1 hypermethylated hypomorphic island itpka leukemic megakaryocyte prdm16 preleukemic progenitors pu publicly robo3 runx1 sca shortage tal1 underscoring
Tagcloud (Intersection) ?