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WNT5A
Gene Name
wingless-type MMTV integration site family, member 5A
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
Proteinaceous Extracellular Matrix
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Lumen
Plasma Membrane
Cell Surface
Clathrin-coated Endocytic Vesicle Membrane
Extracellular Vesicular Exosome
Molecular Function
Sequence-specific DNA Binding Transcription Factor Activity
Frizzled Binding
Frizzled-2 Binding
Receptor Tyrosine Kinase-like Orphan Receptor Binding
Cytokine Activity
Protein Domain Specific Binding
Transcription Regulatory Region DNA Binding
Receptor Agonist Activity
Biological Process
Activation Of MAPK Activity
Ameboidal-type Cell Migration
Establishment Of Planar Polarity
Somitogenesis
Epithelial To Mesenchymal Transition
Neural Tube Closure
Positive Regulation Of Endothelial Cell Proliferation
Heart Looping
Positive Regulation Of Mesenchymal Cell Proliferation
Lens Development In Camera-type Eye
Positive Regulation Of Cytokine Secretion Involved In Immune Response
Type B Pancreatic Cell Development
Optic Cup Formation Involved In Camera-type Eye Development
Protein Phosphorylation
Wnt Signaling Pathway, Calcium Modulating Pathway
Activation Of JUN Kinase Activity
Axon Guidance
Hindgut Morphogenesis
Midgut Development
Male Gonad Development
Anterior/posterior Axis Specification, Embryo
Response To Organic Substance
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Peptidyl-threonine Phosphorylation
Positive Regulation Of T Cell Chemotaxis
Positive Regulation Of Neuron Projection Development
Wnt Signaling Pathway
Olfactory Bulb Interneuron Development
Neuron Differentiation
Keratinocyte Differentiation
Lung Development
Negative Regulation Of BMP Signaling Pathway
Positive Regulation Of CGMP Metabolic Process
Activation Of Protein Kinase B Activity
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Peptidyl-serine Phosphorylation
Cellular Protein Localization
Post-anal Tail Morphogenesis
Non-canonical Wnt Signaling Pathway Via JNK Cascade
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Wound Healing
Embryonic Digit Morphogenesis
Positive Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Chemokine Biosynthetic Process
Cell Fate Commitment
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Ossification
Positive Regulation Of Meiotic Nuclear Division
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Fibroblast Proliferation
Embryonic Skeletal System Development
Genitalia Development
Negative Regulation Of Axon Extension Involved In Axon Guidance
Hypophysis Morphogenesis
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Interleukin-1 Beta Secretion
Positive Regulation Of Inflammatory Response
Negative Chemotaxis
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cartilage Development
Negative Regulation Of Synapse Assembly
Palate Development
Convergent Extension Involved In Organogenesis
Uterus Development
Cervix Development
Vagina Development
Canonical Wnt Signaling Pathway
Urinary Bladder Development
Face Development
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis
Mesenchymal-epithelial Cell Signaling
Negative Regulation Of Prostatic Bud Formation
Mammary Gland Branching Involved In Thelarche
Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation
Positive Regulation Of Response To Cytokine Stimulus
Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis
Positive Regulation Of Macrophage Cytokine Production
Positive Regulation Of Cartilage Development
Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis
Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis
Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis
Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis
Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis
Positive Regulation Of Thymocyte Apoptotic Process
Cellular Response To Lipopolysaccharide
Cellular Response To Calcium Ion
Cellular Response To Retinoic Acid
Cellular Response To Interferon-gamma
Hematopoietic Stem Cell Proliferation
Dopaminergic Neuron Differentiation
Cellular Response To Transforming Growth Factor Beta Stimulus
Negative Regulation Of Mesenchymal Cell Proliferation
Primitive Streak Formation
Positive Regulation Of Protein Kinase C Signaling
Negative Regulation Of Canonical Wnt Signaling Pathway
Cochlea Morphogenesis
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Positive Regulation Of Interleukin-8 Secretion
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
negative regulation of TCF-dependent signaling by WNT ligand antagonists
Signaling by Wnt
GPCR ligand binding
Metabolic disorders of biological oxidation enzymes
WNT ligand biogenesis and trafficking
beta-catenin independent WNT signaling
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Ca2+ pathway
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
Asymmetric localization of PCP proteins
WNT5A-dependent internalization of FZD4
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by WNT in cancer
PCP/CE pathway
Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS
Protein-protein Interactions
3 interactors:
FZD1
FZD5
ROR2
Entrez ID
7474
HPRD ID
01293
Ensembl ID
ENSG00000114251
Uniprot IDs
B3KQX9
P41221
PDB IDs
Enriched GO Terms of Interacting Partners
?
Non-canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Wnt Signaling Pathway
Regulation Of Canonical Wnt Signaling Pathway
Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Wnt Signaling Pathway
Canonical Wnt Signaling Pathway
Segmentation
Epithelium Development
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Signal Transduction
Regulation Of Organ Morphogenesis
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Wnt Signaling Pathway
Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development
Canonical Wnt Signaling Pathway Involved In Osteoblast Differentiation
Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation
Autocrine Signaling
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Anterior/posterior Pattern Specification
Regulation Of Chorionic Trophoblast Cell Proliferation
Wnt Signaling Pathway, Calcium Modulating Pathway
Spemann Organizer Formation
Tissue Development
Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification
Muscular Septum Morphogenesis
Embryonic Genitalia Morphogenesis
Chorionic Trophoblast Cell Differentiation
Chorion Development
Membranous Septum Morphogenesis
Anatomical Structure Morphogenesis
Pattern Specification Process
Hard Palate Development
Regulation Of Tight Junction Assembly
Embryonic Organ Development
Reproductive Structure Development
Positive Regulation Of Cellular Metabolic Process
Post-embryonic Camera-type Eye Development
Branching Involved In Labyrinthine Layer Morphogenesis
Negative Regulation Of Catenin Import Into Nucleus
Reproductive System Development
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Regulation Of Signal Transduction
Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure
Sensory Organ Development
Organ Development
Embryonic Morphogenesis
Tagcloud
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abcb1b
administrated
brosis
colla1
corroborated
dkk1
dkk2
dkk3
dkk4
fi
frizzled
frzb
fz1
fz5
fz7
nano
nephrotoxicity
osteopontin
sfrp
tio2
wnt1
wnt10a
wnt11
wnt2
wnt3
wnt4
wnt6
wnt7a
wnt9a