DGCR14 and FRA10AC1

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid, two hybrid, affinity chromatography technology)

		DGCR14	FRA10AC1
Gene Name		DiGeorge syndrome critical region gene 14	fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Catalytic Step 2 Spliceosome	Nucleus
	Molecular Function	Molecular_function Protein Binding	Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Nervous System Development
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CDK5RAP3 CRP DHX16 FRA10AC1 GNB2L1 LYST PFDN1 RBM4 TTC14 VIM WNK2	27 interactors: ADPRHL2 C21orf33 C7orf25 CCDC155 CHERP CWC27 DGCR14 EEF1D GDPD2 GLRX3 HABP4 IK LPPR4 MAP3K12 MFAP1 NKAP PRPF3 PRPF40A SAP30BP SF3B2 THOC1 TRIM41 TTC14 U2AF1 VPS29 ZCCHC10 ZNF830
Entrez ID		8220	118924
HPRD ID		03452	12319
Ensembl ID		ENSG00000100056	ENSG00000148690
Uniprot IDs		Q96DF8	Q70Z53
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Translation Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Positive Regulation Of CAMP Catabolic Process Mast Cell Secretory Granule Organization Regulation Of Neuron Differentiation Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Ion Homeostasis Regulation Of Cell Differentiation IRES-dependent Translational Initiation Cap-independent Translational Initiation Regulation Of Neurogenesis Endosome Transport Via Multivesicular Body Sorting Pathway Circadian Regulation Of Translation Defense Response To Bacterium Negative Regulation Of Oxidative Stress-induced Neuron Death Bergmann Glial Cell Differentiation Negative Regulation Of Vasodilation Secretion Of Lysosomal Enzymes Protein Ufmylation Negative Regulation Of Translation In Response To Stress Regulation Of Cell Development Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Protein Homooligomerization Positive Regulation Of Gastrulation Phospholipid Homeostasis Regulation Of Gene Expression Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cytoplasmic Translational Initiation Negative Regulation Of Hydrogen Peroxide-induced Cell Death Positive Regulation Of Mitochondrial Depolarization Opsonization Leukocyte Mediated Immunity Adaptive Immune Response Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Phagocytosis Regulation Of Translation Cell Differentiation Central Nervous System Development Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Superoxide Anion Generation Regulation Of Interleukin-8 Secretion Regulation Of Cellular Localization Rhythmic Process Regulation Of Metabolic Process Cytoplasmic Translation Positive Regulation Of Sodium Ion Transmembrane Transport Regulation Of Translation In Response To Stress Negative Regulation Of Macrophage Derived Foam Cell Differentiation	RNA Splicing RNA Processing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Chromosome Localization To Nuclear Envelope Involved In Synapsis Negative Regulation Of Isotype Switching To IgA Isotypes MRNA Export From Nucleus RNA Export From Nucleus Metabolic Process Intestinal Epithelial Structure Maintenance
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