MKKS and IL2RB

		MKKS	IL2RB
Description		MKKS centrosomal shuttling protein	interleukin 2 receptor subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Motile Cilium Ciliary Basal Body Kinociliary Basal Body	Endosome Cytosol Plasma Membrane Interleukin-2 Receptor Complex External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Unfolded Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Cytokine Receptor Activity Interleukin-2 Receptor Activity Protein Binding Coreceptor Activity Interleukin-2 Binding Interleukin-15 Receptor Activity
	Biological Process	Heart Looping Developmental Process Involved In Reproduction Protein Folding Spermatid Development Determination Of Left/right Symmetry Heart Development Visual Perception Sensory Perception Of Smell Gonad Development Gene Expression Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Striatum Development Hippocampus Development Cerebral Cortex Development Negative Regulation Of Actin Filament Polymerization Melanosome Transport Developmental Process Leptin-mediated Signaling Pathway Social Behavior Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Multicellular Organism Growth Vasodilation Response To Leptin Fat Cell Differentiation Photoreceptor Cell Maintenance Negative Regulation Of Blood Pressure Intracellular Transport Animal Organ Development System Development Brain Morphogenesis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Chaperone-mediated Protein Complex Assembly Cartilage Development Regulation Of Stress Fiber Assembly Pigment Granule Aggregation In Cell Center Convergent Extension Involved In Gastrulation Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Face Development Response To Inositol Non-motile Cilium Assembly	Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Phagocytosis Protein-containing Complex Assembly
Pathways		BBSome-mediated cargo-targeting to cilium	RAF/MAP kinase cascade Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Interleukin receptor SHC signaling
Drugs			Denileukin diftitox Aldesleukin Basiliximab Daclizumab
Diseases		46,XX disorders of sex development (Other), including: Mullerian aplasia and hyperandrogenism; McKusick-Kaufman syndrome Bardet-Biedl syndrome (BBS)
GWAS			Asthma ( 20860503 32296059) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) L-selectin levels ( 25576479) Lack of premeditation ( 30718321) Mean corpuscular volume ( 27863252) Rheumatoid arthritis ( 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Tuberculosis ( 24057671) Type 1 diabetes ( 21829393)
Interacting Genes		4 interacting genes: APP CDR2 PTN ZBED1	29 interacting genes: CISH EIF3B FYN GRB2 HGS IL15 IL15RA IL2 IL2RA IL2RG JAK1 JAK3 LCK LYN MTDH PIK3R1 PTPN6 RACK1 RAF1 SHB SHC1 SOCS1 SOCS3 STAT1 STAT3 STAT5A STAT5B SYK TRIP13
Entrez ID		8195	3560
HPRD ID		05356	00896
Ensembl ID		ENSG00000125863	ENSG00000100385
Uniprot IDs		B7Z3W9 Q9NPJ1	P14784
PDB IDs			2B5I 2ERJ 3QAZ 4GS7 5M5E 6E8K 7S2S
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Long-term Synaptic Potentiation Response To Auditory Stimulus Molecular Function Activator Activity Dendrite Membrane Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Dendrite Development Phospholipase C-activating Endothelin Receptor Signaling Pathway Protein Autosumoylation Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Leukocyte Chemotaxis Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Interleukin-15 Receptor Activity Interleukin-2 Binding Interleukin-2 Receptor Activity Interleukin-2 Receptor Complex Dendrite Regeneration Ossification Involved In Bone Remodeling Selenium Compound Metabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Memory Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Modulation Of Chemical Synaptic Transmission Axon Midline Choice Point Recognition Recycling Endosome Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Positive Regulation Of Chemotaxis	Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Hemopoiesis Lymphocyte Activation Regulation Of Multicellular Organismal Development Interleukin-15-mediated Signaling Pathway Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Leukocyte Activation Regulation Of Developmental Process Positive Regulation Of Leukocyte Cell-cell Adhesion Interleukin-2-mediated Signaling Pathway Regulation Of Lymphocyte Differentiation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Lymphocyte Activation Cell Activation Positive Regulation Of Lymphocyte Differentiation Interleukin-9-mediated Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Activation Positive Regulation Of Developmental Process Regulation Of Cell Adhesion Cell Differentiation Mononuclear Cell Differentiation Regulation Of Cell Development Growth Hormone Receptor Signaling Pathway Phosphotyrosine Residue Binding Regulation Of T Cell Differentiation Positive Regulation Of Leukocyte Differentiation Leukocyte Differentiation Regulation Of Multicellular Organismal Process T Cell Activation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Signal Transduction Lymphocyte Differentiation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Lymphocyte Proliferation Cellular Developmental Process Mononuclear Cell Proliferation Positive Regulation Of T Cell Differentiation Interleukin-7-mediated Signaling Pathway Regulation Of Cell Differentiation Activated T Cell Proliferation
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