CLPP and TNFSF9

		CLPP	TNFSF9
Description		caseinolytic mitochondrial matrix peptidase proteolytic subunit	TNF superfamily member 9
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Endopeptidase Clp Complex	Extracellular Space Plasma Membrane Membrane
	Molecular Function	Endopeptidase Activity ATP-dependent Peptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding ATPase Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding
	Biological Process	Proteolysis Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Membrane Protein Proteolysis Mitochondrial Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process	Immune Response Cell Communication Signal Transduction Cell-cell Signaling Signaling Positive Regulation Of Activated T Cell Proliferation Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of Cytotoxic T Cell Differentiation
Pathways		Mitochondrial protein degradation	TNFs bind their physiological receptors
Drugs		N-Formylmethionine
Diseases
GWAS			Metabolite levels ( 23823483)
Interacting Genes		17 interacting genes: ABI2 C14orf119 CHCHD3 CLPX DTX2 EFEMP1 EFEMP2 GRN KRTAP10-1 NUTF2 P4HA3 PLSCR4 PPP2CA PSMB1 RBPMS TNPO3 TRIM54	3 interacting genes: TNFRSF9 TRAF1 TRAF2
Entrez ID		8192	8744
HPRD ID		03074	05861
Ensembl ID		ENSG00000125656	ENSG00000125657
Uniprot IDs		Q16740	A0A0U5J8I0 P41273
PDB IDs		1TG6 6BBA 6DL7 6H23 7UVM 7UVN 7UVR 7UVU 7UW0 7VP9 7WH5 8HGK 8I7X 8W7C 8W7E 8WUZ 8YLB	2X29 6A3V 6BWV 6CPR 6CU0 6D3N 6FIB 6MGE 6MGP
Enriched GO Terms of Interacting Partners?			Thioesterase Binding Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor-mediated Signaling Pathway Signaling Adaptor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity TORC2 Complex Disassembly Positive Regulation Of DNA-binding Transcription Factor Activity TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Endopeptidase Clp Complex Cell Death Programmed Cell Death Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Sphingolipid Binding Regulation Of MRNA Stability Regulation Of RNA Stability IRE1-TRAF2-ASK1 Complex CD27 Signaling Pathway Tumor Necrosis Factor Receptor Superfamily Complex Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding ATP-dependent Peptidase Activity Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding CD40 Receptor Complex Regulation Of MRNA Metabolic Process CD40 Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of JUN Kinase Activity Interleukin-17-mediated Signaling Pathway Mitochondrial Protein Catabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of Apoptotic Signaling Pathway TORC2 Signaling Cellular Response To Nitric Oxide Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Mitogen-activated Protein Kinase Kinase Kinase Binding Cellular Response To Reactive Nitrogen Species Negative Regulation Of Nitric Oxide Biosynthetic Process Exosome (RNase Complex) Negative Regulation Of Lipoprotein Particle Clearance 3'-UTR-mediated MRNA Destabilization Cytokine-mediated Signaling Pathway Regulation Of Low-density Lipoprotein Particle Clearance Response To Nitric Oxide Programmed Necrotic Cell Death
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