CLPP and STAT4

Data Source: HiPPIP (Novel)

		CLPP	STAT4
Name		caseinolytic mitochondrial matrix peptidase proteolytic subunit	signal transducer and activator of transcription 4
Structure			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Endopeptidase Clp Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Endopeptidase Activity ATP-dependent Peptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding ATPase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding
	Biological Process	Proteolysis Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Membrane Protein Proteolysis Mitochondrial Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Defense Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Interleukin-12-mediated Signaling Pathway Regulation Of Cell Population Proliferation Response To Peptide Hormone T-helper 1 Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Response To Interleukin-6
Pathways		Mitochondrial protein degradation	Interleukin-20 family signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-21 signaling Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
Drugs		N-Formylmethionine	None
GWAS		No GWAS studies recorded	Arthritis (juvenile idiopathic) ( 33106285 ) Autoimmune thyroid disease ( 32581359 ) Autoimmune traits (pleiotropy) ( 30572963 ) Behcet's disease ( 23291587 23001997 ) Celiac disease ( 22057235 30572963 25920553 ) Celiac disease and Rheumatoid arthritis ( 26546613 ) Celiac disease or Rheumatoid arthritis ( 21383967 ) Eosinophil count ( 32888494 ) Gamma glutamyl transferase levels ( 29403010 ) Generalized epilepsy ( 30531953 ) Hepatocellular carcinoma in hepatitis B infection ( 23242368 ) Idiopathic inflammatory myopathy ( 26362759 ) Inflammatory bowel disease ( 23128233 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Limited cutaneous systemic scleroderma ( 29293537 ) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 ) Medication use (thyroid preparations) ( 31015401 ) Multiple sclerosis ( 24076602 31604244 ) Nontyphoidal Salmonella bacteraemia ( 29523850 ) Primary biliary cholangitis ( 26394269 28425483 23000144 21399635 ) Primary biliary cirrhosis ( 22961000 ) Rheumatoid arthritis ( 30572963 23143596 24390342 32723749 30423114 20453841 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676 ) Sjögren's syndrome ( 28076899 24097067 24097066 ) Systemic lupus erythematosus ( 32771030 28714469 33272962 19165918 23273568 18204098 19838193 19838195 21408207 23053960 24871463 26316170 26606652 26502338 27399966 26663301 ) Systemic lupus erythematosus and Systemic sclerosis ( 23740937 ) Systemic sclerosis ( 28314753 33069728 20383147 29293537 21750679 31672989 21779181 30572963 24387989 ) Systemic sclerosis (anti-centromere-positive) ( 29293537 ) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655 ) Type 1 diabetes ( 34127860 ) Vitiligo ( 27723757 )
Novel Interactors		2 novel interactors: STAT4 TNFSF9	10 novel interactors: CADM3 CCDC85A CLPP DNAH7 HNRNPCP2 LY86 NABP1 NEMP2 PTMS TMEFF2
Interacting Genes		17 interacting genes: ABI2 C14orf119 CHCHD3 CLPX DTX2 EFEMP1 EFEMP2 GRN KRTAP10-1 NUTF2 P4HA3 PLSCR4 PPP2CA PSMB1 RBPMS TNPO3 TRIM54	13 interacting genes: ADRB2 CREBBP CRK IL12RB1 IL12RB2 JUN MAP2K6 MAPK14 NMI PIAS2 SH2D1B STAT3 ZNF467
Entrez ID		8192	6775
HPRD ID		03074	02779
Ensembl ID		ENSG00000125656	ENSG00000138378
Uniprot IDs		Q16740	Q14765
PDB IDs		1TG6 6BBA 6DL7 6H23 7UVM 7UVN 7UVR 7UVU 7UW0 7VP9 7WH5 8HGK 8I7X 8W7C 8W7E 8WUZ 8YLB	Not available
GO Terms Enriched among Interactors		None	Regulation Of Defense Response Immune System Process Cell Surface Receptor Signaling Pathway Interleukin-23-mediated Signaling Pathway Response To Stress NLRP1 Inflammasome Complex Assembly Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response Interleukin-12-mediated Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Energy Homeostasis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Immune Response Cellular Response To UV-B MAP Kinase Kinase Activity Cell Activation T-helper 1 Cell Differentiation Cellular Response To UV Regulation Of Innate Immune Response Positive Regulation Of Defense Response Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Light Stimulus Response To UV-B Stress-activated MAPK Cascade Negative Regulation Of Defense Response P38MAPK Cascade Stress-activated Protein Kinase Signaling Cascade SMAD Protein Signal Transduction Response To Muscle Stretch Positive Regulation Of Innate Immune Response Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Immune System Process Response To Peptide Leukocyte Activation Canonical Inflammasome Complex Assembly Positive Regulation Of Erythrocyte Differentiation Temperature Homeostasis Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Signal Transduction Positive Regulation Of Mini Excitatory Postsynaptic Potential Response To UV Lipopolysaccharide-mediated Signaling Pathway T-helper Cell Differentiation Interleukin-12 Receptor Activity Negative Regulation Of Integrin Biosynthetic Process Cellular Response To Radiation Enzyme-linked Receptor Protein Signaling Pathway Pyroptotic Inflammatory Response Leukocyte Differentiation