CLPP and TNPO3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLPP	TNPO3
Description		caseinolytic mitochondrial matrix peptidase proteolytic subunit	transportin 3
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Endopeptidase Clp Complex	Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Endopeptidase Activity ATP-dependent Peptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding ATPase Binding	Protein Binding Small GTPase Binding Identical Protein Binding Nuclear Import Signal Receptor Activity
	Biological Process	Proteolysis Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Membrane Protein Proteolysis Mitochondrial Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process	Protein Import Into Nucleus Protein Transport
Pathways		Mitochondrial protein degradation
Drugs		N-Formylmethionine
Diseases
GWAS			Diffuse cutaneous systemic sclerosis ( 29293537) Limited cutaneous systemic scleroderma ( 29293537) Platelet count ( 32888494) Plateletcrit ( 32888494) Primary biliary cholangitis ( 20639880) Primary biliary cirrhosis ( 22961000) Sjögren's syndrome ( 24097067) Systemic lupus erythematosus ( 18204446 32771030 28714469 26606652 26502338 24871463 23053960 18204098) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 29293537 30247649 31672989 21750679) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Ulcerative colitis ( 23128233 21297633)
Interacting Genes		17 interacting genes: ABI2 C14orf119 CHCHD3 CLPX DTX2 EFEMP1 EFEMP2 GRN KRTAP10-1 NUTF2 P4HA3 PLSCR4 PPP2CA PSMB1 RBPMS TNPO3 TRIM54	23 interacting genes: BLMH CAMK2B CAMK2D CAMK2G CEBPA CHMP3 CLPP ECI2 GCH1 ICA1L KRT75 KRTAP10-8 MEOX2 NME1 PPP1R1C PTEN RNF10 SMURF2 SRSF1 SSX2 SSX2B TRA2B USP7
Entrez ID		8192	23534
HPRD ID		03074	18209
Ensembl ID		ENSG00000125656	ENSG00000064419
Uniprot IDs		Q16740	B3KMX1 C9J7E5 E9PFH4 Q9Y5L0
PDB IDs		1TG6 6BBA 6DL7 6H23 7UVM 7UVN 7UVR 7UVU 7UW0 7VP9 7WH5 8HGK 8I7X 8W7C 8W7E 8WUZ 8YLB	4C0O 4C0P 4C0Q 4OL0 6GX9 8CMK
Enriched GO Terms of Interacting Partners?			Calcium- And Calmodulin-dependent Protein Kinase Complex Identical Protein Binding Calcium/calmodulin-dependent Protein Kinase Activity Sarcoplasmic Reticulum Membrane Long-term Synaptic Potentiation Regulation Of Neuronal Synaptic Plasticity Regulation Of System Process Sarcoplasmic Reticulum Regulation Of Skeletal Muscle Adaptation Endocytic Vesicle Membrane Ubiquitin-specific Protease Binding Postsynaptic Density Regulation Of Protein Localization To Plasma Membrane Regulation Of Cellular Localization
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