CLPP and CLPX

Number of citations of the paper that reports this interaction (PubMedID 11923310)
0

Data Source:
HPRD (in vitro)

		CLPP	CLPX
Description		caseinolytic mitochondrial matrix peptidase proteolytic subunit	caseinolytic mitochondrial matrix peptidase chaperone subunit X
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Endopeptidase Clp Complex	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Endopeptidase Clp Complex Mitochondrial Endopeptidase Clp Complex Mitochondrial Nucleoid
	Molecular Function	Endopeptidase Activity ATP-dependent Peptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding ATPase Binding	Nucleotide Binding ATP-dependent Peptidase Activity Protein Binding ATP Binding Zinc Ion Binding Peptidase Activator Activity Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding Protein Dimerization Activity Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Proteolysis Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Membrane Protein Proteolysis Mitochondrial Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process	Protein Folding Proteolysis ATP Metabolic Process Proteolysis Involved In Protein Catabolic Process
Pathways		Mitochondrial protein degradation	Mitochondrial protein degradation
Drugs		N-Formylmethionine
Diseases
GWAS
Interacting Genes		17 interacting genes: ABI2 C14orf119 CHCHD3 CLPX DTX2 EFEMP1 EFEMP2 GRN KRTAP10-1 NUTF2 P4HA3 PLSCR4 PPP2CA PSMB1 RBPMS TNPO3 TRIM54	4 interacting genes: CLPP FBXL17 FILNC1 OGT
Entrez ID		8192	10845
HPRD ID		03074	07478
Ensembl ID		ENSG00000125656	ENSG00000166855
Uniprot IDs		Q16740	O76031
PDB IDs		1TG6 6BBA 6DL7 6H23 7UVM 7UVN 7UVR 7UVU 7UW0 7VP9 7WH5 8HGK 8I7X 8W7C 8W7E 8WUZ 8YLB
Enriched GO Terms of Interacting Partners?			Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Endopeptidase Clp Complex ATP-dependent Peptidase Activity Proteolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Regulation Of Transcription By Glucose Mitochondrial Protein Catabolic Process NSL Complex Neural Crest Cell Differentiation
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