CLPP and CHCHD3

Number of citations of the paper that reports this interaction (PubMedID 30877431)
90

Data Source:
BioGRID (proximity labelling technology, pull down)

		CLPP	CHCHD3
Description		caseinolytic mitochondrial matrix peptidase proteolytic subunit	coiled-coil-helix-coiled-coil-helix domain containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Endopeptidase Clp Complex	SAM Complex Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Crista Junction MICOS Complex Extracellular Exosome MIB Complex
	Molecular Function	Endopeptidase Activity ATP-dependent Peptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding ATPase Binding	Protein Binding Phosphatase Binding Molecular Adaptor Activity
	Biological Process	Proteolysis Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Membrane Protein Proteolysis Mitochondrial Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process	Inner Mitochondrial Membrane Organization Mitochondrial Fusion Cristae Formation
Pathways		Mitochondrial protein degradation	Mitochondrial protein import Cristae formation
Drugs		N-Formylmethionine
Diseases
GWAS			Chronotype ( 30696823) Food allergy ( 29030101) Intercellular adhesion molecule 1 (red blood cell fatty acid level interaction) ( 28820441) Metabolite levels ( 23823483) Peanut allergy ( 29030101) Smoking status (ever vs never smokers) ( 30643258) Urinary potassium excretion ( 31409800)
Interacting Genes		17 interacting genes: ABI2 C14orf119 CHCHD3 CLPX DTX2 EFEMP1 EFEMP2 GRN KRTAP10-1 NUTF2 P4HA3 PLSCR4 PPP2CA PSMB1 RBPMS TNPO3 TRIM54	40 interacting genes: AMOTL2 ANKS1A ARMC7 BLZF1 CALCOCO2 CATSPERT CBY2 CCDC33 CCDC85B CEP72 CLPP CYSRT1 EFHC1 ENKD1 FANCL GMCL2 GOLGA2 KANK2 KRT40 KRTAP4-12 LMO1 LZTS2 NBPF19 NOTCH2NLA NTAQ1 NUDT3 NUTF2 NUTM1 PDE4DIP PPP1CB RAB3IP RBM11 RPGRIP1 SAMM50 SPAG5 SSX2IP TRAF1 TRIM27 UBC USHBP1
Entrez ID		8192	54927
HPRD ID		03074	13044
Ensembl ID		ENSG00000125656	ENSG00000106554
Uniprot IDs		Q16740	A4D1N4 B7Z1X9 C9JRZ6 Q9NX63
PDB IDs		1TG6 6BBA 6DL7 6H23 7UVM 7UVN 7UVR 7UVU 7UW0 7VP9 7WH5 8HGK 8I7X 8W7C 8W7E 8WUZ 8YLB
Enriched GO Terms of Interacting Partners?			Spindle Organization Cytoplasm Microtubule Organizing Center Organization Cytoskeleton Centrosome Microtubule Cytoskeleton Organization Microtubule-based Process Centrosome Cycle
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