STAT4

Gene Name		signal transducer and activator of transcription 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Transcription, DNA-templated Protein Phosphorylation JAK-STAT Cascade Cell Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS		Behcet's disease ( 23001997 23291587) Celiac disease and Rheumatoid arthritis ( 21383967) Hepatocellular carcinoma (hepatitis B virus related) ( 23242368) Inflammatory bowel disease ( 23128233) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Primary biliary cirrhosis ( 23000144 21399635) Rheumatoid arthritis ( 20453841 20453842) Systemic lupus erythematosus ( 23273568 23053960 18204098 21408207 19165918 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 21750679 20383147 21779181)
Protein-protein Interactions		13 interactors: ADRB2 CREBBP IFNGR1 IL12RB1 IL12RB2 JUN MAP2K6 MAPK14 NMI PIAS2 STAT3 UBC ZNF467
Entrez ID		6775
HPRD ID		02779
Ensembl ID		ENSG00000138378
Uniprot IDs		Q14765
PDB IDs
Enriched GO Terms of Interacting Partners?		Defense Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Toll-like Receptor Signaling Pathway Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Cell Communication RNA Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To Stress Activation Of Innate Immune Response Response To Cytokine Cellular Response To Organic Substance Immune Response Regulation Of Signal Transduction Positive Regulation Of Transcription, DNA-templated Cellular Response To Stimulus Positive Regulation Of Innate Immune Response Cytokine-mediated Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Immune Response Intracellular Receptor Signaling Pathway Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Signaling Cell Surface Receptor Signaling Pathway MAPK Cascade Peptidyl-amino Acid Modification Positive Regulation Of Gene Expression RNA Metabolic Process Regulation Of Cell Differentiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?		activate activated activating autocrine bind capable clear cytotoxicity distinct enhances exerts ifn il induces leads mitogen nk occur occurs populations primarily resting similarity stat1 stat5 underlie unique uniquely