STAT4 and PTMS

		STAT4	PTMS
Description		signal transducer and activator of transcription 4	parathymosin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body RNA Polymerase II Transcription Regulator Complex	Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding	Histone Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Defense Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Interleukin-12-mediated Signaling Pathway Regulation Of Cell Population Proliferation Response To Peptide Hormone T-helper 1 Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Response To Interleukin-6	Immune System Process DNA Replication Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Interleukin-20 family signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-21 signaling Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
Drugs
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Behcet's disease ( 23291587 23001997) Celiac disease ( 22057235 30572963 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil count ( 32888494) Gamma glutamyl transferase levels ( 29403010) Generalized epilepsy ( 30531953) Hepatocellular carcinoma in hepatitis B infection ( 23242368) Idiopathic inflammatory myopathy ( 26362759) Inflammatory bowel disease ( 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Limited cutaneous systemic scleroderma ( 29293537) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602 31604244) Nontyphoidal Salmonella bacteraemia ( 29523850) Primary biliary cholangitis ( 26394269 28425483 23000144 21399635) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 30572963 23143596 24390342 32723749 30423114 20453841) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sjögren's syndrome ( 28076899 24097067 24097066) Systemic lupus erythematosus ( 32771030 28714469 33272962 19165918 23273568 18204098 19838193 19838195 21408207 23053960 24871463 26316170 26606652 26502338 27399966 26663301) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 28314753 33069728 20383147 29293537 21750679 31672989 21779181 30572963 24387989) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Type 1 diabetes ( 34127860) Vitiligo ( 27723757)
Interacting Genes		13 interacting genes: ADRB2 CREBBP CRK IL12RB1 IL12RB2 JUN MAP2K6 MAPK14 NMI PIAS2 SH2D1B STAT3 ZNF467	8 interacting genes: APP GET4 NKX3-1 NR3C1 RXRB SCHIP1 SDCBP2 SMAD2
Entrez ID		6775	5763
HPRD ID		02779	01344
Ensembl ID		ENSG00000138378	ENSG00000159335
Uniprot IDs		Q14765	A0A158RFU3 F5GXR3 P20962
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Defense Response Immune System Process Cell Surface Receptor Signaling Pathway Interleukin-23-mediated Signaling Pathway Response To Stress NLRP1 Inflammasome Complex Assembly Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response Interleukin-12-mediated Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Energy Homeostasis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Immune Response Cellular Response To UV-B MAP Kinase Kinase Activity Cell Activation T-helper 1 Cell Differentiation Cellular Response To UV Regulation Of Innate Immune Response Positive Regulation Of Defense Response Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Light Stimulus Response To UV-B Stress-activated MAPK Cascade Negative Regulation Of Defense Response P38MAPK Cascade Stress-activated Protein Kinase Signaling Cascade SMAD Protein Signal Transduction Response To Muscle Stretch Positive Regulation Of Innate Immune Response Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Immune System Process Response To Peptide Leukocyte Activation Canonical Inflammasome Complex Assembly Positive Regulation Of Erythrocyte Differentiation Temperature Homeostasis Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Signal Transduction Positive Regulation Of Mini Excitatory Postsynaptic Potential Response To UV Lipopolysaccharide-mediated Signaling Pathway T-helper Cell Differentiation Interleukin-12 Receptor Activity Negative Regulation Of Integrin Biosynthetic Process Cellular Response To Radiation Enzyme-linked Receptor Protein Signaling Pathway Pyroptotic Inflammatory Response Leukocyte Differentiation	Positive Regulation Of Transcription By RNA Polymerase II Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Receptor Activity DNA-binding Transcription Factor Activity Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Hormone-mediated Signaling Pathway Identical Protein Binding Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Reproductive Behavior Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Receptor Signaling Pathway DNA Binding Cell Population Proliferation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Response To Growth Factor Amylin Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Toll Signaling Pathway Nuclear Glucocorticoid Receptor Activity Response To Lipid Positive Regulation Of Androgen Secretion MADS Box Domain Binding Positive Regulation Of Neuron Apoptotic Process Cytosol Positive Regulation Of Macromolecule Biosynthetic Process Response To Transforming Growth Factor Beta Positive Regulation Of Signal Transduction Regulation Of MiRNA Transcription Positive Regulation Of Biosynthetic Process Nucleoplasm Response To Interleukin-1 Cellular Response To Steroid Hormone Stimulus Acetylcholine Receptor Activator Activity Positive Regulation Of Cell Communication Regulation Of MiRNA Metabolic Process Positive Regulation Of Signaling Lipoprotein Particle Positive Regulation Of Protein Import RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Tissue Morphogenesis Homomeric SMAD Protein Complex Dorsal Aorta Development
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