DAGLB and PISD

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DAGLB	PISD
Gene Name		diacylglycerol lipase, beta	phosphatidylserine decarboxylase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Integral Component Of Membrane	Nucleus Mitochondrion
	Molecular Function	Lipase Activity Metal Ion Binding	Phosphatidylserine Decarboxylase Activity
	Biological Process	Neuroblast Proliferation Blood Coagulation Lipid Catabolic Process Arachidonic Acid Metabolic Process Platelet Activation Neurotransmitter Biosynthetic Process	Phospholipid Metabolic Process Phosphatidylethanolamine Biosynthetic Process Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process
Pathways		G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Arachidonate production from DAG Platelet activation, signaling and aggregation Effects of PIP2 hydrolysis	Metabolism of lipids and lipoproteins Synthesis of PE Phospholipid metabolism Glycerophospholipid biosynthesis
Drugs			Phosphatidylserine
Diseases
GWAS			Intelligence ( 22449649) Paclitaxel-induced neuropathy ( 23776197)
Protein-Protein Interactions		1 interactors: PISD	3 interactors: BRCA1 DAGLB DHX29
Entrez ID		221955	23761
HPRD ID		17324	17854
Ensembl ID		ENSG00000164535	ENSG00000241878
Uniprot IDs		Q8NCG7	Q9UG56
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphatidylethanolamine Biosynthetic Process Glycerophospholipid Biosynthetic Process Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Phospholipid Metabolic Process Glycerolipid Metabolic Process	Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Fatty Acid Metabolic Process Cellular Response To Indole-3-methanol Negative Regulation Of Centriole Replication Dosage Compensation By Inactivation Of X Chromosome Protein K6-linked Ubiquitination Regulation Of Histone H3-K9 Acetylation Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Regulation Of Histone H4 Acetylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Fatty Acid Biosynthetic Process DNA Damage Response, Signal Transduction Resulting In Transcription Monocarboxylic Acid Metabolic Process Negative Regulation Of Histone Methylation Neurotransmitter Biosynthetic Process Negative Regulation Of Centrosome Duplication Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Positive Regulation Of Histone Acetylation Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Histone H3-K4 Methylation Negative Regulation Of Protein Acetylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Postreplication Repair Regulation Of Transcription From RNA Polymerase III Promoter Negative Regulation Of Fatty Acid Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Neurotransmitter Metabolic Process Genetic Imprinting Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Vascular Endothelial Growth Factor Production G2 DNA Damage Checkpoint Positive Regulation Of Histone Methylation Positive Regulation Of DNA Repair Cellular Lipid Metabolic Process Androgen Receptor Signaling Pathway Regulation Of Centrosome Duplication Protein Autoubiquitination Carboxylic Acid Metabolic Process Regulation Of Histone Acetylation
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